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Objectives: In this study we investigated the diagnostic and prognostic significance of the 2002 European League Against Rheumatism (EULAR) criteria for the clinical suspicion of rheumatoid arthritis (RA) and the sensitivity of the new 2010 American College of Rheumatology (ACR)/EULAR classification criteria for RA in patients with "early arthritis". Patients and methods: The subjects were 250 outpatients (211 females, 39 males; mean age 46.1±11.8 years; range 19 to 73 years) with"early ar thritis". The mean disease duration was 4.9±3.3 months. The criteria of inclusion of patients in the study were: (i) patients aged 18 years and older, (ii) clinical suspicion of RA according to EULAR (2002) criteria or persistent arthritis/arthralgia (>6 weeks), (iii) duration of disease <1 year, and (iv) written consent of the patient to participate in the study. The exclusion criteria were: (i) presence of a definite diagnosis of other rheumatic diseases before the onset of the study, and (ii) refusal of the patient to participate in the study. The diagnostic significance of the criteria was determined by the sensitivity and specificity. Predictive significance was estimated on positive and negative predictive values. The diagnostic effectiveness was also considered. Results: The 2002 EULAR criteria had higher diagnostic accuracy in identifying all three criteria in the patients. The negative predictive values ranging from 87.84% to 98.0% indicate that the absence of one of these criteria, especially arthritis of three or more joints, reduces the probability of RA diagnosis and requires investigation for other possible diseases with involvement of the joints. Two criteria was found to have the highest sensitivity among the 2010 ACR/EULAR classification criteria for RA: (i) the presence of synovitis in at least one joint, and (ii) symptom duration ≥6 weeks."Definite" RA could be identified in 98 (86%) patients according to new criteria (a score of ≥6/10) at the beginning of the study. Conclusion: The obtained data indicates the feasibility of using the 2002 EULAR criteria for screening patients with early RA and the usefulness of the new 2010 ACR/EULAR classification criteria for identification patients with"definite RA" and initiation of therapy with disease-modifying antirheumatic drugs. © 2011 Turkish League Against Rheumatism. All rights reserved. Source


Zheleznov L.M.,Orenburg State Medical Academy
Morfologii{combining double inverted breve}a (Saint Petersburg, Russia) | Year: 2012

Lung holotopy, skeletotopy and syntopy were studied in 70 human fetuses at developmental weeks 16-24 with N. I. Pirogov method, macro-microscopical preparation and using histotopographical sections in three imutually perpendicular planes. It was found that during weeks 16-18, the apex of the left lung was located posteriorly at the level of I intercostal space, at weeks 22-24--at the level of lower surface of I rib. At the right side, the apex was located at the level of upper surface of I rib during the whole period. The lower margin of the right lung was located at the level of IV rib during the whole period, while that of the left lung was detected at the level of III rib only during the beginning of the period. In the early fetal period, the projection of the root of the right lung extended from the lower margin of T(III) vertebral body toT(VI), while that one of the left lung was located at the level of the upper margins of T(IV)-T(VII) vertebral bodies. In the late period, these projections were found at the level of T(IV) (upper vertebral margin)--T(VII) (lower vertebral margin), and T(IV) (lower vertebral margin)--T(VIII) (upper vertebral margin) respectively. Intraorgan bronchi and pulmonary vessels were most clearly visualized in horizontal sections at T(III) -T(IX) levels. The results obtained should be taken into account when carrying out of diagnostic ultrasound and magnetic resonance studies of the fetus and surgical interventions on fetuses. Source


Malyshkin A.P.,Orenburg State Medical Academy
Immunobiology | Year: 2010

There is no fundamental difference in contagiousness or pathogenicity between the normal and pathogenic microfloras: both are contagious, and both may either cause illness or persist in the body of a healthy carrier. The contagiousness of the normal microflora is determined by its positive function in the host. In addition to the normal microflora, endogenous retrovirus genes are also useful for a macroorganism: they have been found to be integral elements of many animal and plant genomes and participate in vital functions, such as genome activity control, antiviral defense, and formation of the placenta; dysfunction of some endogenous retrovirus genes causes pathology. Components of bacterial cells cause protective effects with respect to noninfectious somatic diseases. Therefore, it is reasonable to assume that natural susceptibility to both "normal" and "pathogenic" microfloras results from vital necessity for a macroorganism to interact with them. The necessity to interact with specific microorganisms and, hence, susceptibility to them is the cause of their infectivity. In this connection, studies on the positive functions of specific "pathogenic" microflora in a macroorganism with the use of SPF animals would be of interest. Even more interesting would be experiments with transfer of specific microbial genes into the genomes of susceptible species, which may help to understand the causes and mechanisms of susceptibility/insusceptibility as a basis of species immunity and develop fundamentally new and more natural methods for preventing and treating infectious diseases. © 2009 Elsevier GmbH. Source


Senchukova M.,Orenburg State Medical Academy | Kiselevsky M.V.,Institute of Experimental Diagnostics and Therapy of Tumors
Journal of Cancer | Year: 2014

The "cavitary" type of angiogenesis in patients with gastric cancer (GC) is described for the first time. Material and methods: The samples of tumour and adjacent gastric mucosa (GM) in 73 patients with GC who had undergone radical surgery were being studied. The sections were stained with hematoxylin and eosin (H and E) and immunohistochemically (IGH) using antibodies to CD34. Results: ? new type of vessel formation consists of the appearance of cavitary structures (CS) in tumours and the adjacent GM, which are then lined by endothelial cells and merged into the blood vessels of the organ. We believe that the CS can be formed by means: 1) of the abruption of layers of epithelial cells (both normal and tumoral) from their underlying foundation and their desquamation into the lumen of the "obliterated" gastric glands (GG); 2) of the dilatation of the GG and thinning of their walls; 3) of the formation of "cavity" directly in the lamina propria of GM or in the tumoral stroma. It was noted that only the presence of multiple "cavitary" vessels (CV) of type-1 had been associated with the decrease of 3-year overall survival (OR=15,0, 95%CI=2,96-76,31) and relapse-free survival (OR=14,93, 95%CI=4,34-51,38). We also observed the improvement of the long-term outcomes in patients with GC having received antibacterial therapy (AT) before surgery that can be associated with its influence on the formation of CV type-1. Conclusion: The described new type of angiogenesis is of great clinical importance. © Ivyspring International Publisher. Source


Aptikeeva N.V.,Orenburg State Medical Academy
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2015

This literature review is devoted to the differential diagnosis of central and peripheral vestibular vertigo from the point of view of modern otoneurology. In addition, an own case is given. © 2015, Media Sphera. All rights reserved. Source

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