NEWARK, CA, United States

Oraya Therapeutics, Inc

www.orayainc.com
NEWARK, CA, United States

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Patent
Oraya Therapeutics, Inc | Date: 2014-07-21

Radiosurgery systems are described that are configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, and in some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, a fiducial marker is used to identify the location of the target tissues.


Patent
Oraya Therapeutics, Inc | Date: 2013-01-29

Embodiments provide method and systems for determining or measuring objective eye alignment in an external-coordinate system so as to define a reference axis. Additional embodiments provide a method and system of aligning an objectively determined reference axis of the eye in a selected relationship to a therapeutic axis of an ophthalmic therapeutic apparatus and/or a diagnostic axis of an ophthalmic diagnostic apparatus. Embodiments provide a method and system for planning an ophthalmic treatment procedure based on objective eye alignment in an external-coordinate system so as to define a reference axis of an eye to be treated. The reference axis may be used to position a therapeutic energy component, for example, an orthovoltage X-ray treatment device, e.g., positioned to provide treatment to tissue on the retina, such as the macula.


Patent
Oraya Therapeutics, Inc | Date: 2013-06-12

A system of defining a reference axis of a patients eye in an external coordinate system, comprising: a light source for directing a light beam on a reflective surface associated with the patients eye, an imaging system for recording an image of a limbus of the patients eye and an image formed by a reflection of the light beam from a cornea of the patients eye, and a processor operatively connected to the imaging system to, from the image of the limbus, determine the center of the limbus of the patients eye in the external-coordinate system, and, from the image of the reflection, determine when the position of the reflection is coincident with the center of the limbus, at which position an axis normal to the cornea defines the reference axis.


Patent
Oraya Therapeutics, Inc | Date: 2016-03-09

A radiosurgery system describes a therapeutic radiation delivery to a target structure in a patient. The radiosurgery system treats inflammatory ocular disorders; places ocular structures in a global coordinate system based on ocular imaging; automates ocular structures inside the global coordinate system to direction of a positioning system that is directed based on ocular structures within the coordinate system; tracks and relates the position of ocular structures to the status of the radiosurgery system; determines beam energy and direction and duration of time for treatment for a specific disease to be treated and/or structures to be avoided; tracks structure of an eye; holds and fixes the eye is in place; places a fiducial is on the eye to aid in positioning; positions the eye off the refelction; and combines with other treatments and can be delivered concomitant with, prior to, or following other treatments.


Grant
Agency: Department of Health and Human Services | Branch: | Program: STTR | Phase: Phase I | Award Amount: 215.20K | Year: 2014

Project Description The purpose of this project is to develop a new radiotherapy treatment modality that will substantially enhance the treatment of wet AMD with minimal toxicity to healthy tissue, leading to major improvement in visual acuity, decreaseduse of intravitreal injections of anti-VEGF agents, lower cost of treatment, and a substantially improved quality of life for patients. The new modality entitled Customizable Radiotherapy Enhancement (CuRE) using gold nanoparticles will enable major highly localized amplification of radiation damage to the neovascular AMD disease cells with minimal normal ocular tissue toxicity. In order to accomplish this, a potent amount of gold nanoparticles (AuNP), acting as smart bombs will be targeted specificallyto the neovascular AMD (disease) endothelial cells (ECs) as demonstrated in published simulations by Harvard Medical School project partner. Once the AuNP home on to the disease ECs, a relatively small amount of radiation will be focused on the AuNP. The


Patent
Oraya Therapeutics, Inc | Date: 2013-12-17

A portable orthovoltage radiotherapy system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system.


Patent
Oraya Therapeutics, Inc | Date: 2016-03-09

A radiosurgery system describes a therapeutic radiation delivery to a target structure in a patient. The radiosurgery system treats inflammatory ocular disorders; places ocular structures in a global coordinate system based on ocular imaging; automates ocular structures inside the global coordinate system to direction of a positioning system that is directed based on ocular structures within the coordinate system; tracks and relates the position of ocular structures to the status of the radiosurgery system; determines beam energy and direction and duration of time for treatment for a specific disease to be treated and/or structures to be avoided; tracks structure of an eye; holds and fixes the eye is in place; places a fiducial is on the eye to aid in positioning; positions the eye off the refelction; and combines with other treatments and can be delivered concomitant with, prior to, or following other treatments.


Patent
Oraya Therapeutics, Inc | Date: 2016-03-16

A radiosurgery system describes a therapeutic radiation delivery to a target structure in a patient. The radiosurgery system treats inflammatory ocular disorders; places ocular structures in a global coordinate system based on ocular imaging; automates ocular structures inside the global coordinate system to direction of a positioning system that is directed based on ocular structures within the coordinate system; tracks and relates the position of ocular structures to the status of the radiosurgery system; determines beam energy and direction and duration of time for treatment for a specific disease to be treated and/or structures to be avoided; tracks structure of an eye; holds and fixes the eye is in place; places a fiducial is on the eye to aid in positioning; positions the eye off the refelction; and combines with other treatments and can be delivered concomitant with, prior to, or following other treatments.


Patent
Oraya Therapeutics, Inc | Date: 2016-03-09

A radiosurgery system describes a therapeutic radiation delivery to a target structure in a patient. The radiosurgery system treats inflammatory ocular disorders; places ocular structures in a global coordinate system based on ocular imaging; automates ocular structures inside the global coordinate system to direction of a positioning system that is directed based on ocular structures within the coordinate system; tracks and relates the position of ocular structures to the status of the radiosurgery system; determines beam energy and direction and duration of time for treatment for a specific disease to be treated and/or structures to be avoided; tracks structure of an eye; holds and fixes the eye is in place; places a fiducial is on the eye to aid in positioning; positions the eye off the refelction; and combines with other treatments and can be delivered concomitant with, prior to, or following other treatments.


Patent
Oraya Therapeutics, Inc | Date: 2014-01-13

Embodiments provide method and systems for determining or measuring objective eye alignment in an external-coordinate system so as to define a reference axis. Additional embodiments provide a method and system of aligning an objectively determined reference axis of the eye in a selected relationship to a therapeutic axis of an ophthalmic therapeutic apparatus and/or a diagnostic axis of an ophthalmic diagnostic apparatus. Embodiments provide a method and system for planning an ophthalmic treatment procedure based on objective eye alignment in an external-coordinate system so as to define a reference axis of an eye to be treated. The reference axis may be used to position a therapeutic energy component, for example, an orthovoltage X-ray treatment device, e.g., positioned to provide treatment to tissue on the retina, such as the macula.

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