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Paramus, NJ, United States

Peterson M.E.,Animal Endocrine Clinic | Peterson M.E.,Cornell University | Eirmann L.,Oradell Animal Hospital | Eirmann L.,Nestle
Veterinary Clinics of North America - Small Animal Practice

When treating cats with endocrine disease, most veterinarians concentrate on medical or surgical treatments that can be used to manage or cure the disease. Dietary issues are frequently ignored or not properly addressed. However, nutritional support can play an integral role in the successful management of feline endocrine diseases. Furthermore, because most cats with endocrine disease are senior or geriatric, they may also have concurrent health conditions that warrant dietary intervention. This article discusses recommendations for nutritional support of the 2 most common endocrine problems of cats seen in clinical practice: hyperthyroidism and diabetes mellitus. © 2014 Elsevier Inc. Source

Murphy L.A.,Oradell Animal Hospital | Russell N.J.,Advanced Veterinary Care Center | Dulake M.I.,VCA West Los Angeles Animal Hospital | Nakamura R.K.,Veterinary Medical Surgical Group Orange County
Journal of Feline Medicine and Surgery

A 4-year-old female spayed domestic longhair cat was referred for dyspnea. Further diagnostics revealed severe pleural effusion and a peritoneopericardial diaphragmatic hernia (PPDH). Following surgical correction of the PPDH the pleural effusion persisted. Re-check echocardiogram 4 weeks after initial evaluation revealed leftward deviation of the interventricular septum and interatrial septum occurring with inspiration. There were also exaggerated phasic changes in trans-tricuspid flow velocities suggestive of constrictive pericardial disease. Cardiac catheterization was performed and revealed elevated pressures in the right atrium and right ventricle. Constrictive pericarditis (CP) and epicarditis was confirmed at surgery, where subtotal pericardiectomy was performed with epicardial decortication. The cat continued to develop recurrent pleural effusion after surgery, although the volume and frequency of recurrence slowed over time. This is the first reported case of CP following PPDH repair in a cat. © ISFM and AAFP 2014. Source

Waite A.,Cornell University | Balkman C.,Cornell University | Bailey D.,Oradell Animal Hospital | Kiselow M.,Sage Center for Veterinary Specialty and Emergency Care | And 4 more authors.
Veterinary and Comparative Oncology

The goal of the current study was to determine the efficacy of oral docetaxel in combination with cyclosporine in the treatment of canine epithelial cancer. Requirements for eligibility were histological confirmation of epithelial neoplasia, measurable disease, no chemotherapy treatment within 2 weeks, and a life expectancy of≥3 months. Fifty-one dogs were enrolled. All dogs received 1.625mgkg-1 of docetaxel with 5mgkg-1 of cyclosporine (DT/CSA) by gavage. Ten dogs had progressive disease at 2 weeks, one dog died, and one dog was withdrawn from the study. Thirty-nine dogs were given a second dose of DT/CSA, three each receiving a third or fourth dose. Eight dogs had a dose reduction (1.5mgkg-1) and six dogs had treatment delays primarily for gastrointestinal toxicity. The overall response rate was 16.7% (8/48 had a partial response there were no complete responses). The highest response rate was seen in dogs with oral squamous cell carcinoma (50%; 6/12). © 2012 John Wiley & Sons Ltd. Source

Shmuel D.L.,Oradell Animal Hospital
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)

To review and summarize current information regarding the pathophysiology and clinical manifestations associated with anaphylaxis in dogs and cats. The etiology, diagnosis, treatment, and prognosis is discussed. Anaphylaxis is a systemic, type I hypersensitivity reaction that often has fatal consequences. Many of the principal clinical manifestations involve organs where mast cell concentrations are highest: the skin, the lungs, and the gastrointestinal tract. Histamine and other deleterious inflammatory mediators promote vascular permeability and smooth muscle contraction; they are readily released from sensitized mast cells and basophils challenged with antigen. Anaphylaxis may be triggered by a variety of antigens including insect and reptile venom, a variety of drugs, vaccines, and food. Anaphylaxis is a clinical diagnosis made from a collection of signs and symptoms. It is most commonly based on pattern recognition. Differential diagnoses include severe asthma, pheocromocytoma, and mastocytosis. Epinephrine is considered the drug of choice for the treatment of anaphylaxis. It acts primarily as a vasopressor in improving hemodynamic recovery. Adjunctive treatments include fluid therapy, H1 and H2 antihistamines, corticosteroids, and bronchodilators; however, these do not substitute for epinephrine. Prognosis depends on the severity of the clinical signs. The clinical signs will vary among species and route of exposure. The most severe clinical reactions are associated when the antigen is administered parenterally. © Veterinary Emergency and Critical Care Society 2013. Source

Schrope D.P.,Oradell Animal Hospital
Journal of Veterinary Cardiology

A 10-year-old cat presented with a history of unexplained ascites. Ultrasound and angiography identified an isolated stenosis of the middle hepatic vein resulting in Budd-Chiari Syndrome. Balloon dilation of the stenosis was attempted but the patient expired. Necropsy revealed a discrete membranous stenosis at the junction of the caudal vena cava and the middle hepatic vein. The literature was reviewed to assess clinical and diagnostic findings, as well as therapeutic options in humans with hepatic vein stenosis. © 2010 Elsevier B.V. All rights reserved. Source

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