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The present invention provides topical ophthalmic formulations comprising a combination of one or more antihistamine agents and optionally one or more vasculature modifying agents such as a adrenergic receptor antagonist. Also provided are methods of using the formulations of the invention for treating and/or preventing symptoms associated with migraine headache, and for reducing the frequency, severity and duration of migraine attacks.


News Article | May 17, 2017
Site: www.businesswire.com

CHICAGO--(BUSINESS WIRE)--The Escape Pod Group, an independent, full-service ad agency collective, today announced that it has named veteran marketing executive Celia Jones Brand Director. In this role, she will be responsible for amplifying the agency brand and managing PR and marketing initiatives across the group’s three partner agencies: The Escape Pod, digital agency ORA Interactive, and experiential agency OutCold. “Celia brings a mix of strategic thinking and proven experience helping brands and agencies carve out their unique position in the marketplace. The Escape Pod has grown significantly over the past 10 years. Given our recent strategic acquisitions we can provide clients with true full-service capabilities, while still moving faster and more cost-effectively than larger shops. Today brands need a nimble strategic partner. That’s a space that we can own, so now is the perfect time for Celia to join our leadership team and help crystallize our story,” said Norm Bilow, Managing Director, The Escape Pod Group. Prior to The Escape Pod Group, Celia held senior marketing roles at various agencies including Rightpoint, one of the nation’s largest privately held digital agencies, and Havas Worldwide Chicago, where she crafted the ad agency’s brand narrative as a creative force and culture catalyst in the industry, and led external marketing, PR, events, awards and internal culture initiatives. Before that, Celia was Global Marketing Director for Critical Mass, where she helped catapult the digital agency from a niche player into a world-class experience design agency. She also served as Director of Content and lead Copywriter at Designkitchen, an interactive marketing and branding agency. “Between the rampant consolidation in our industry and the jargon that so many agencies use to describe themselves, it’s very hard to tell the difference between one agency and the next. It is incredibly refreshing for me to be a part of an organization with such a clear vision of what they stand for. The Escape Pod was founded on an independent spirit and fearless approach to creativity. Innovative brands are hiring us to disrupt long-established categories. And they made key investments to position the agency for the future. It’s an exciting time in our evolution and I’m looking forward to playing a key role in their trajectory,” said Celia Jones, Brand Director, The Escape Pod Group. The Escape Pod Group is a collective of specialty agencies, purpose-built to deliver breakthrough ideas with speed, agility and cost-savings for clients. We combine creative firepower with full-service capabilities across creative, digital, social and experiential marketing. Our mission: amplifying brands across all channels to drive growth. Learn more at www.theescapepodgroup.com.


Spécialiste de la Data et du Digital, acteur leader de la Business Intelligence (analyse des données structurées de l'entreprise) et de la gestion de la relation client (CRM), Business & Decision regroupe 2 500 collaborateurs en France et à l'international, notamment en Europe. A l'issue de la procédure d'information et de consultation des instances représentatives du personnel de Network Related Services (filiale d'Orange) et de Business & Decision, et sous réserve de conditions suspensives usuelles, notamment l'approbation des autorités de la concurrence concernées, l'acquisition serait réalisée en numéraire sur la base d'un prix maximum de 7,93 euros par action. Aujourd'hui, Orange Business Services est déjà leader en matière de transport de données grâce à son savoir-faire réseau, et est fortement positionné sur les domaines de la collecte et de l'hébergement des données. L'acquisition de Business & Decision et son expertise en matière de Business Intelligence et de science des données (Data Science) notamment viendraient renforcer significativement en France et à l'international les activités d'Orange Business Services dans la gouvernance et l'analyse des données. De leur côté, les équipes et clients de Business & Decision bénéficieraient de l'étendue des compétences d'opérateur et d'intégrateur d'Orange Business Services dans les domaines de l'Internet des Objets, du cloud computing, de la cybersécurité et du développement applicatif, ainsi que de l'envergure internationale de son réseau commercial pour accompagner les multinationales partout dans le monde. « Business & Decision et Orange Business Services partagent une vraie culture numérique et un socle d'expertises communes tout en étant très complémentaires en matière d'offres. Nous sommes convaincus que la combinaison de l'expertise de Business & Decision en matière de Data et de Business Intelligence et de notre double savoir-faire d'opérateur et d'intégrateur de services de traitements des données serait un levier clé pour accélérer la transformation digitale de nos entreprises clientes et notre croissance dans ce domaine », déclare Thierry Bonhomme, Directeur Général Adjoint du groupe Orange en charge d'Orange Business Services. « Cette opération correspond parfaitement à la réalisation de nos objectifs stratégiques autour de nos deux offres clés, la Data et le Digital. C'est une opportunité pour Business & Decision et ses équipes de déployer nos expertises sur de nouveaux marchés en France et à l'International et de continuer à investir et innover sur les technologies de la Data. Les valeurs de Business & Decision, chères à son fondateur, et tournées vers le respect des collaborateurs, sont également partagées par Orange, ce qui annonce, j'en suis sûr, un projet réussi », déclare Christophe Dumoulin, dirigeant de Business & Decision. « Je me réjouis que Business & Decision rejoigne un acteur qui partage les valeurs chères à son fondateur Patrick Bensabat dans le respect de l'intérêt de ses collaborateurs et de ses clients. Cette union apportera le nouvel élan dont l'entreprise qu'il a créée a besoin. Les équipes de Business & Decision, pour lesquelles Patrick avait la plus haute estime et la plus grande affection, vont contribuer au succès du groupe Orange en apportant leur expertise et leurs compétences ", déclare enfin Tova Bensabat, membre du Conseil d'Administration et représentante du bloc majoritaire familial. Orange est l'un des principaux opérateurs de télécommunications dans le monde, avec un chiffre d'affaires de 40,9 milliards d'euros en 2016 et 155 000 salariés au 31 décembre 2016, dont 96 000 en France. Présent dans 29 pays, le Groupe servait 263 millions de clients dans le monde au 31 décembre 2016, dont 202 millions de clients mobile et 18 millions de clients haut débit fixe. Orange est également l'un des leaders mondiaux des services de télécommunications aux entreprises multinationales sous la marque Orange Business Services. En mars 2015, le Groupe a présenté son nouveau plan stratégique « Essentiels2020 » qui place l'expérience de ses clients au coeur de sa stratégie, afin que ceux-ci puissent bénéficier pleinement du monde numérique et de la puissance de ses réseaux très haut débit. Orange est coté sur Euronext Paris (symbole ORA) et sur le New York Stock Exchange (symbole ORAN). Pour plus d'informations (sur le web et votre mobile) : www.orange.com, www.orange-business.com ou pour nous suivre sur Twitter : @presseorange. Orange et tout autre produit ou service d'Orange cités dans ce communiqué sont des marques détenues par Orange ou Orange Brand Services Limited. Business & Decision est un Groupe international de consulting et d'intégration de systèmes, leader de la Business Intelligence (BI) et du CRM, acteur majeur de l'e-Business. Le Groupe contribue à la réussite des projets à forte valeur ajoutée des entreprises et accompagne ses clients dans des domaines d'innovation tels que le Big Data et le Digital. Il est reconnu pour son expertise fonctionnelle et technologique par les plus grands éditeurs de logiciels du marché avec lesquels il a noué des partenariats. Fort d'une expertise unique dans ses domaines de spécialisation, Business & Decision offre des solutions adaptées à des secteurs d'activité ainsi qu'à des directions métiers. Présent dans 12 pays, Business & Decision emploie plus de 2 500 personnes en France et dans le monde.         Plus d'informations, sur www.group.businessdecision.com


Not for distribution in the United States of America Orange enters exclusive negotiations to acquire Business & Decision to accelerate Orange Business Services' growth in data intelligence Orange announces that it has entered into exclusive negotiations to acquire a controlling stake of around 67 percent of Business & Decision, a company listed on Euronext Paris, from the majority shareholders - the Bensabat family and Christophe Dumoulin. Specialising in data and digital services, Business & Decision is a leading player in Business Intelligence and CRM (Customer Relationship Management). The company has 2,500 employees in France and internationally, particularly in Europe. The transaction will be finalized following the procedure of informing and consulting the employee representative bodies of both Network Related Services (an Orange subsidiary) and Business & Decision. It is also subject to the usual suspensive conditions, including the approval of the relevant competition authorities. Once these conditions have been met, the operation will be carried out in cash on the basis of a maximum price of 7.93 euros per share. In the event of the successful acquisition of a majority stake, Orange will file a simplified public offer for all Business & Decision shares it does not hold. To do this, and subject to the approval of market authorities, Orange will offer shareholders 7.93 euros per share in cash, which corresponds to the maximum price paid by the majority shareholders. This price of 7.93 euros per share represents a premium of 34 percent compared to the average share price over the previous 12 months. The offer values the entire capital of Business & Decision at approximately 62.5 million euros. Trading was suspended on Monday, 8 May 2017 following market rumours published in the media on Friday, 5 May 2017. This acquisition project is part of Orange Business Services' development strategy, which aims to position it as a global player in digital transformation and as a global leader across the entire data services value-chain. Today, Orange Business Services is already a global leader in secure data transport services thanks to its expertise in network management and is well positioned in data collection and storage. The acquisition of Business & Decision and, in particular, its expertise in Business Intelligence and data science, would significantly strengthen the activities of Orange Business Services in France and internationally in data governance and data analysis. Business & Decision's teams and customers stand to benefit from the breadth of Orange Business Services' capabilities as an operator and integrator in areas such as the internet of things, cloud computing, cybersecurity and application development. They will also benefit from the international scope of the Orange Business Services sales network that supports multinational corporations around the world. "Business & Decision and Orange Business Services share a genuine digital culture based on common skill sets, while offering complementary catalogues of services to their customers. We are convinced that the combination of Business & Decision's expertise in data and Business Intelligence and our dual know-how as an operator and service integrator will be a key lever that will enable us to accelerate the digital transformation of our enterprise customers and stimulate growth," said Thierry Bonhomme, the Orange Group's Deputy CEO in charge of Orange Business Services. "This operation is perfectly in line with the realization of our strategic objectives around our two key offerings: data and digital services. It is an opportunity for Business & Decision and its teams to deploy our expertise in new markets in France and internationally, and to continue to invest and innovate in data-driven technologies. The values of Business & Decision, which are dear to its founder, and that are focused on the respect of its employees, are also shared by Orange, and I am convinced that this is an excellent indicator of the future success of this project," said Christophe Dumoulin, Managing Director of Business & Decision. "I am extremely happy that Business & Decision is joining a group that shares the same values as the company's founder Patrick Bensabat with regards to assuring the best interests of the company's employees and customers. This union will bring the fresh dynamic which the company that he created now needs to move forward. Business & Decision's teams, that Patrick had cherished with enormous esteem and affection, will now contribute to the success of the Orange Group by bringing their expertise and operational efficiency," said Tova Bensabat, Board member and representative of the family-held majority ownership. The transaction is expected to be completed by the end of the third quarter of 2017. Orange is one of the world's leading telecommunications operators with sales of 40,9 billion euros in 2016 and 154,000 employees worldwide at 31 March 2017, including 95,000 employees in France. Present in 29 countries, the Group has a total customer base of 265 million customers worldwide at 31 March 2017, including 203 million mobile customers and 19 million fixed broadband customers. Orange is also a leading provider of global IT and telecommunication services to multinational companies, under the brand Orange Business Services. In March 2015, the Group presented its new strategic plan "Essentials2020" which places customer experience at the heart of its strategy with the aim of allowing them to benefit fully from the digital universe and the power of its new generation networks. Orange is listed on Euronext Paris (symbol ORA) and on the New York Stock Exchange (symbol ORAN). For more information on the internet and on your mobile: www.orange.com, www.orange-business.com or to follow us on Twitter: @orangegrouppr. Orange and any other Orange product or service names included in this material are trademarks of Orange or Orange Brand Services Limited. About Business & Decision Business & Decision, a global consulting and systems integration group (CSI), is a leader in Business Intelligence (BI) and CRM, and is a leading e-Business player. The Group contributes to the success of high added-value projects for businesses and supports its customers in various innovative areas such as Big Data and digital services. The company is recognized for its operational and technical expertise by leading software developers with whom it has built-up solid partnerships. With its unique capabilities in its specialist areas, Business & Decision offers tailored solutions for a broad range of sectors and industry functions. Business & Decision operates in 12 countries and employs more than 2,500 people in France and around the world.


ROAD TOWN, BRITISH VIRGIN ISLANDS--(Marketwired - May 29, 2017) - Aura Minerals Inc. (TSX: ORA) announces the results of the votes held at the Annual General and Special Meeting of Shareholders (the "Meeting") held in Road Town, Tortola, British Virgin Islands. The Company announces the retirement of Patrick Mars from the Company's Board of Directors. Patrick joined the Company as a Director in 2006 and he served as the Chairman of the Board from 2008 to 2016 and held positions on several Board committees, including Chairman of the Audit Committee. Patrick was instrumental in the purchases of the San Andres, Sao Francisco and Sao Vincente mine acquisitions that turned the Company into a producer. Jim Bannantine, did not stand for re-election due to personal reasons but noted that his decision did not have anything to do with his view of the Company or that it will affect his shareholdings in the Company. The Company would like to extend their warmest thanks to Jim for steering the Company through a difficult time in the market with declining commodity prices and his restructuring initiatives to reduce costs. The Company also announces that due to personal reasons of outside employment, Juarez Saliba did not stand for re-election at the Meeting. Rodrigo Barbosa, the Company's President & CEO stated, "On behalf of management and the Board of Directors, we express our sincere appreciation for Patrick's and Jim's many years of service and for the year of service from Juarez. It has been a rewarding experience working with all of them during my tenure at the Company and we wish them continued success." For additional details on these matters, please see the Management Information Circular of the Company dated April 25, 2017 and the Company's amendment dated May 2, 2017 (together, the "Information Circular").


News Article | June 20, 2017
Site: www.prweb.com

Today, ORA Sound, launched a Kickstarter campaign for ORA GrapheneQ Headphones, featuring proprietary graphene membranes that enable new levels of fidelity. They are the first commercial audio product to leverage the “wonder material” that was discovered in 2004. The headphones are now available for the early bird price of $199 (retail price $499). ORA GrapheneQ Headphones have been designed with comfort and sound isolation in mind. Thanks to its graphene membranes, listeners will enjoy one of the smoothest frequency responses recorded, zero distortion, and crystal clear resolution at low, mid and high frequencies. “As a trained audio engineer I have dedicated my life to the study and practice of accuracy in sound reproduction,” said Co-Founder Robert-Eric Gaskell. “After my brother and I completed our PhDs, we worked together designing and building audio equipment for professional recording studios. It became clear to us that graphene had the ideal mechanical characteristics for loudspeakers and microphones. We patented the idea and wrote a paper for the Audio Engineering Society on the use of graphene in ribbon microphones. Shortly thereafter we were approached by a technology incubator and assembled a team to explore its potential.” The result was the development of GrapheneQ, a proprietary nanocomposite formulation consisting of 95%+ graphene. Speaker membranes made with this material display a rare combination of high stiffness and low density which translates to acoustic qualities on par with the highest performing materials on the market at a significantly reduced cost. “Digital processes (DSP) have become a band-aid for masking the limitations of audio technology,“ said Co-Founder Ari Pinkas. ”While DSP is a powerful tool, improving the fundamental technology is a far superior approach.” ORA GrapheneQ Headphones feature GrapheneQ membranes for excellent tonality and superior dampening, high efficiency drivers for extended battery life, touchpad controls to skip songs, control volume and answer calls, high quality electret built-in microphone for hands-free calling, and ear-shaped design optimized for fit and ergonomics. The headphones have an adjustable, padded headband for ultimate comfort, a frame composed of anodized aluminium and steel for robustness with wooden earcups for optimized acoustics. ORA’s campaign runs from June 20 to July 20, 2017. For a full rundown of the pledge levels visit the Kickstarter page. Media wishing to interview their personnel should contact PR agent, Allison Aitken at +1 (514) 703-4989. About ORA Sound ORA’s team consists of chemists, material scientists and audio engineers who have come together to bring better listening experiences en masse. The company is currently working with major OEMs that are seeking to include GrapheneQ technology inside the next generation of: TVs, home audio, hearing aids, cellphones, laptops, tablets, automobiles and other consumer electronics.


Gomes P.J.,ORA Inc
Current Opinion in Allergy and Clinical Immunology | Year: 2014

Purpose of review: This review describes recent findings and trends in prevalence and treatment of allergic ocular diseases. Although the major focus is on seasonal and perennial allergic conjunctivitis, related disorders will also be considered. Recent findings: Published reports from countries around the world suggest that the spectrum of atopic diseases, including seasonal and perennial allergic conjunctivitis, is continuing its pattern of increasing prevalence, which has been well documented over the past few decades. In addition, although treatment modalities have focused on topical formulations including antihistamines and corticosteroids, there is a significant emphasis on immunotherapy as an alternative treatment modality, particularly in the USA. Summary: Allergic conjunctivitis is a key component in the spectrum of allergic diseases that is sometimes collectively referred to as rhinoconjunctivitis. Because of its high prevalence worldwide, it exacts an increasing toll in terms of patient discomfort, morbidity, and loss of productivity. Current estimates suggest that at least 20% of the overall population suffers from some form of allergic conjunctivitis, many without ever seeking treatments. In addition, a significant proportion of patients experience chronic forms of allergy that are less responsive to existing therapies. Recent approval of immunotherapy-based treatments may address this therapeutic gap. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.


Patent
ORA Inc | Date: 2011-08-15

This is directed to systems, processes, machines, and other means that simulate blast waves from explosive events. The invention can make waveforms tailored to a users preference to accurately model a variety of explosive events by utilizing a driver section and a transition section that have divergent geometries.


Patent
ORA Inc | Date: 2015-09-29

Disclosed herein are systems, methods, and machine readable media for visualizing complex data, including real-time data streams from wearable device sensors, using a halo-based representation. Halos are comprised of multiple rings that can be used to efficiently convey, for example, information about the status of a subject, such as a subjects heart rate, activity level, and calories burned at particular times throughout a day.


The present invention provides topical ophthalmic formulations comprising a combination of one or more antihistamine agents and optionally one or more vasculature modifying agents such as a adrenergic receptor antagonist. Also provided are methods of using the formulations of the invention for treating and/or preventing symptoms associated with migraine headache, and for reducing the frequency, severity and duration of migraine attacks.

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