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Zipursky S.,Optimize | Djingarey M.H.,World Health Organization | Lodjo J.-C.,Ministry of Health | Olodo L.,Ministry of Health | Ronveaux O.,World Health Organization
Vaccine | Year: 2014

Background: In October 2012, the Meningococcal A conjugate vaccine MenAfriVac was granted a label variation to allow for its use in a controlled temperature chain (CTC), at temperatures of up to 40. °C for not more than four days. This paper describes the first field use of MenAfriVac in a CTC during a campaign in Benin, December 2012, and assesses the feasibility and acceptability of the practice. Methods: We implemented CTC in one selected district, Banikoara (target population of 147,207; 1-29 years of age), across 14 health facilities and 150 villages. We monitored the CTC practice using temperature indicators and daily monitoring sheets. At the end of the campaign we conducted a face-to-face survey to assess vaccinators' and supervisors' experience with CTC. Findings: A mix of strategies were implemented in the field to maximize the benefits from CTC practice, depending on the distance from health centre to populations and the availability of a functioning refrigerator in the health centre. Coverage across Banikoara was 105.7%. Over the course of the campaign only nine out of approx. 15,000 vials were discarded due to surpassing the 4 day CTC limit and no vial was discarded because of exposure to a temperature higher than 40. °C or due to the Vaccine Vial Monitor (VVM) reaching its endpoint. Overall confidence and perceived usefulness of the CTC approach were very high among vaccinators and supervisors. Interpretation: Vaccinators and supervisors see clear benefits from the CTC approach in low income settings, especially in hard-to-reach areas or where cold chain is weak. Taking advantage of the flexibility offered by CTC opens the door for the implementation of new immunization strategies to ensure all those at risk are protected. © 2014.


Bard J.F.,University of Texas at Austin | Nananukul N.,Optimize
Computers and Operations Research | Year: 2010

With globalization, the need to better integrate production and distribution decisions has become ever more pressing for manufacturers trying to streamline their supply chain. This paper investigates a previously developed mixed-integer programming (MIP) model aimed at minimizing production, inventory, and delivery costs across the various stages of the system. The problem being modeled includes a single production facility, a set of customers with time varying demand, a finite planning horizon, and a fleet of homogeneous vehicles. Demand can be satisfied from either inventory held at a customer site or from daily product distribution. Whether a customer is visited on a particular day is determined by an implicit tradeoff between inventory and distribution costs. Once the decision is made, a vehicle routing problem must be solved for those customers who are scheduled for a delivery. A hybrid methodology that combines exact and heuristic procedures within a branch-and-price framework is developed to solve the underlying MIP. The approach takes advantage of the efficiency of heuristics and the precision of branch and price. Implementation required devising a new branching strategy to accommodate the unique degeneracy characteristics of the master problem, and a new procedure for handling symmetry. A novel column generation heuristic and a rounding heuristic were also implemented to improve algorithmic efficiency. Computational testing on standard data sets showed that the hybrid scheme can solve instances with up to 50 customers and 8 time periods within 1 h. This level of performance could not be matched by either CPLEX or standard branch and price alone. © 2010 Elsevier Ltd. All rights reserved.


Miller R.,LMI | Cheyne J.,Optimize
Health Affairs | Year: 2011

In the next decade, at least twelve additional vaccines that target such diseases as typhoid, malaria, and dengue will become available to lower- and middle-income countries. These vaccines must travel along what are called supply chains, which include all personnel, systems, equipment, and activities involved in ensuring that vaccines are effectively delivered from the point of production to the people who need them. But for various reasons, supply chains are already strained in many developing countries, and the potential inability to distribute new vaccines will place lives at risk. Among the many steps needed to strengthen the global vaccine supply chain, we suggest that the international community pursue improved coordination between organizations that donate and ship vaccines and the host-country officials who receive and distribute the vaccines, as well as better training for supply-chain managers. © 2011 Project HOPE-The People-to-People Health Foundation, Inc.


Patent
Optimize | Date: 2012-05-18

A fitting assembly for use in a fluid transfer assembly includes a fluid conduit having a first fitting with first and second ends and a bore extending between the first and second ends for receiving the fluid conduit. The first end of the first fitting is configured to sealingly dispose a ferrule assembly within a second fitting in an engaged position. The fitting assembly further includes a third fitting having first and second ends and a bore extending between the first and second ends for receiving the fluid conduit. The first end of the third fitting is configured to sealingly dispose a collet assembly within the first fitting in an engaged position.


Trademark
Optimize | Date: 2012-07-10

Magnetic coded gift cards. Promoting the goods and services of others by providing an interactive website where users can increase the current value of an online discount being offered by purchasing the goods and services associated with that discount in the form of an online coupon, voucher or gift card.


Trademark
Optimize | Date: 2012-07-10

Magnetic coded gift cards. Promoting the goods and services of others by providing an interactive website where users can increase the current value of an online discount being offered by purchasing the goods and services associated with that discount in the form of an online coupon, voucher or gift card.


Trademark
Optimize | Date: 2012-10-23

Air filters for air conditioning units.


Trademark
Optimize | Date: 2011-06-21

Dieting pills and powder preparations to promote fat burning available with a prescription and containing HCG. Providing a website featuring information and advice in the fields of diet, weight loss, diet planning and lifestyle wellness; Weight reduction diet planning and supervision. Regulatory compliance consulting as it applies to prescription drug sampling for drugs containing HCG.


Trademark
Optimize | Date: 2011-10-11

dieting pills and powder preparations to promote fat burning available with a prescription and containing HCG; prescription and non-prescription medicines, namely, pills, tablets, capsules, caplets, liquid drops, sachets and pharmaceutical preparations for the treatment of cardiovascular disorders containing or directly promoting the production of HCG. weight loss program kits consisting primarily of printed booklets on weight loss and dieting, and also including vitamin supplements and hormones. providing a website featuring information and advice in the fields of diet, weight loss, diet planning and lifestyle wellness.


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