Bera K.M.,Opp. Kaya Beauty Clinic |
Ghule R.S.,Opp. Kaya Beauty Clinic |
Kapdiya N.S.,Opp. Kaya Beauty Clinic |
Shah M.B.,Opp. Kaya Beauty Clinic |
Upadhyay U.M.,Opp. Kaya Beauty Clinic
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011
Brain tonic activity of Shankhavali churna was studied. Decoction (DSC) of Shankhavali churna was prepared. DSC (300 mg/kg) was administered intraperitoneally in Wistar albino rats using elevated plus maze (EPM) and step through (ST) paradigm models. Scopolamine (0.3 mg/kg) was used to induce cognitive dysfunction and piracetam (100 mg/kg) as standard nootropic drug. In elevated plus maze DSC increased transfer latency (TL) and inflexion ratio (IR). There was increase of the step-through latency in step-through model by DSC. DSC also reversed the effect of scopolamine in both experiments. It is concluded that Shankhavali churna shows significant brain tonic activity.