Mastropasqua L.,University of Chieti Pescara |
Lanzini M.,University of Chieti Pescara |
Curcio C.,University of Chieti Pescara |
Calienno R.,University of Chieti Pescara |
And 4 more authors.
Investigative Ophthalmology and Visual Science | Year: 2014
PURPOSE. The aim of this study is to investigate modifications in human cadaver corneas after different crosslinking procedures, including standard epi-off treatment, iontophoresis imbibition, and different exposure to ultraviolet A (UVA) sources (30 minutes at 3 mW and 9 minutes at 10 mW). METHODS. A total of 12 human cadaver corneas was examined and divided as follows: 3 served as control (group 1), 3 were treated with a standard epi-off procedure (group 2), 6 underwent iontophoresis imbibition for 5 minutes, and then 3 were irradiated for 30 minutes with 3 mW UVA (group 3), and 3 for 9 minutes at 10 mW UVA (group 4). Deformation amplitude index was measured before and after the corneas underwent treatment. After treatment, corneas were prepared for hematoxylin-eosin and immunohistochemistry evaluation. The expression of TUNEL, matrix metalloproteinase-1 (MMP-1), collagen type I, and CD34 was investigate in all samples. RESULTS. The deformation amplitude index decreased in all groups, in particular in group 4, indicating an improvement of corneal biomechanical properties. Immunohistochemical staining showed a significant stromal alteration in group 2, mild damage in group 3, and no modifications in corneal morphology in group 4. The TUNEL (P < 0.001) and MMP-1 (P = 0.002) positivity was more evident in group 4. Collagen type I positivity significantly increased in groups 3 (P = 0.002) and 4 (P = 0.002). The CD34 expression was more evident in groups 2 (P = 0.003) and 3 (P = 0.003). CONCLUSIONS. Iontophoresis imbibition followed by UVA irradiation for 9 minutes at 10 mW determined less tissue damage and better stromal remodeling. © 2014 The Association for Research in Vision and Ophthalmology, Inc.
McGregor M.L.,Ophthalmology Clinic
Pediatric Clinics of North America | Year: 2014
There is no standard meaning of the term "vision therapy", and for this reason it is often a controversial topic between some members of the ophthalmic and optometric community. Most pediatric ophthalmologists avoid using the term because it is nonspecific. Convergence Insufficiency (CI) is a binocular visual problem that causes problems and symptoms with near fixation. There is consensus among eye care professionals that convergence therapy is effective in treating CI. Convergence therapy is not effective in treating learning disabilities, but can sometimes relieve symptoms that might be a barrier to reading. © 2014 Elsevier Inc.
Celebi A.R.C.,Ophthalmology Clinic
Aging Clinical and Experimental Research | Year: 2014
Aim: The aim of this study was to determine if aging is a factor that increases the intraoperative complication rate during phacoemulsification surgery. Materials and methods: Patients who underwent phacoemulsification surgery were divided into three age groups according to World Health Organization classification, as follows: ≤59, 60-74, and ≥75 years. The intraoperative complications which occurred during the operation were recorded. Binary logistics regression analysis, Pearson's correlation analysis, and Duncan's (multiple range) test were used for statistical analysis. Results: In total, 789 patients who underwent phacoemulsification surgery at Nigde State Hospital, Ophthalmology Clinic between 01 July 2010 and 31 October 2012 were retrospectively reviewed, and intraoperative complications that occurred during surgery were recorded. Mean age of the patients was 68.98 years (range 38-93 years). In all, 132 (16.7%) patients were aged ≤59 years, 406 (51.5%) were aged 60-74 years, and 251 (31.8%) were aged ≥75 years. The complication rates were 3.78% in the ≤59-year-old age group, 5.17% in the 60- to 74-year-old age group, and 5.30% in the ≥75-year-old age group. Age did not have a significant effect on intraoperative complication rates during phacoemulsification surgery, according to binary logistic regression analysis (P = 0.58) and Pearson's correlation analysis (P = 0.076). The incidence and risk of intraoperative complications in the age groups did not differ statistically (Duncan's test, P = 0.18). Conclusion: Age has no effect on the rate of intraoperative complications during phacoemulsification surgery. © Springer International Publishing 2013.
Eraslan M.,Ophthalmology Clinic
Marmara Medical Journal | Year: 2012
Unilateral unresponsive dilatation of the pupil is an alarming finding and may be secondary to a wide range of ocular and neurological disorders. Ocular side effects, particularly pupillary dilation with blurring of vision may be alarming because they can indicate potentially lethal conditions related to some kinds of plants with local and systemic effects. It may also be only a topical side effect without any systemic disorder. We herein report a case of mydriasis related to the datura plant. The right pupil of the patient was dilated and unresponsive to both the pupillary light reflex (direct, consensual) and the accommodation reflex. There was no accompanying headache, diplopia, or other neurological symptom. Topical pilocarpine 2% induced normal constriction of the left pupil but had no effect on the right, confirming the pharmacological basis of the right mydriasis. Pupil size and accommodation gradually returned to normal after three days without any treatment. In some conditions as in this case the pupil dilation with blurring of vision is only a topical side effect of some kinds of plants without any systemic disorder. A detailed history and this simple topical pilocarpin test provided us vaulable information and eliminated the need for unnecessary expensive neuro-imaging and the use of unnecessary medication. It also prevented us from squandering the time of the emergency services. © Marmara Medical Journal, Published by Galenos Publishing.
Atalay E.,Ophthalmology Clinic |
Tamcelik N.,Cerrahpasa Medical Faculty |
Cicik M.E.,Cerrahpasa Medical Faculty
Current Eye Research | Year: 2015
Purpose: To investigate the change in pre-and post-dilation anterior segment parameters and intraocular pressure (IOP) of patients with and without pseudoexfoliation, after topical application of phenylephrine HCl 10% and tropicamide 1%. Materials and methods: Totally 129 eyes of 129 patients were included in the study. Of the 129 eyes; 31 had pseudoexfoliation syndrome (PXS), 37 had pseudoexfoliation glaucoma (PXG), 31 eyes were the fellow eyes of subjects with unilateral pseudoexfoliation syndrome (subclinical PXS) and 30 eyes were the eyes of subjects without PXS (controls). Patients underwent Pentacam analysis and IOP measurement before and after dilation. The changes in IOP, anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA), central corneal thickness (CCT) and pupillary diameter (PD) were investigated 30min after the application of mydriatic agents. Results: The mean change of IOP in eyes with PXS, in eyes with PXG, in eyes with subclinical PXS and eyes of control subjects were 1.45±2.03mmhg, 0.27±2.25mmhg,-0.35±1.58mmHg and-1.06±1.59mmHg, respectively. Post-dilation IOP values were lower (p=0.001) in eyes of controls but higher (p<0.001) in eyes of PXS than the pre-dilation levels. All patients exhibited statistically significant increase in ACD, ACV and PD after the dilation procedure (p<0.001). Additionally, post dilation CCT values were significantly lower than pre-dilation values in all groups; the difference was statistically significant only for eyes with PXG, eyes with subclinical PXS and eyes of controls. Conclusion: Eyes with PXS had a higher tendency of IOP elevation after pupillary dilation. Eyes with subclinical PXS, however, exhibited a minor increase in IOP, reflecting the asymmetrical character of the disease. Anti-glaucoma medications may have blunted any IOP elevation induced by pupillary dilation in eyes with PXG. © 2015 Informa Healthcare USA, Inc.