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Gama R.R.,University of Sao Paulo | Gama R.R.,Operative Technique and Experimental Surgery Laboratory | Giovanini A.,Positivo University | De Rosa F.S.,Centro Universitario Da Fundacao Educacional Of Barretos | And 9 more authors.
ecancermedicalscience | Year: 2014

Objective: To study the potential chemopreventive effects of polyunsaturated fatty acids omega-3 in Swiss mice submitted to oral and oesophageal carcinogenesis induction by 4-nitroquinoline-1-oxide (4-NQO). Study design: The animals underwent carcinogenesis induction with 50 ?g/mL 4-NQO for eight weeks. The animals were divided into groups: Group I4-NQO induction without chemoprevention, Group IIchemoprevention with the addition of 5% fish oil (FO) in their diet after 4-NQO carcinogenesis induction, and Group IIIchemoprevention with 5% FO in their diet during and after 4-NQO carcinogenesis induction. Results: The incidence of invasive oral carcinoma was: Group I (72.9%), Group II (84.2%), and Group III (64.7%); p = 0.34. The difference in the incidence of invasive oesophageal carcinoma was statistically significant: Group I (37.8%), Group II (68.4%), and Group III (29.4%); p = 0.02. © the authors.

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