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Heerlen, Netherlands

Phillips C.,The London School of Economics and Political Science | Earle R.,Open University
British Journal of Criminology | Year: 2010

Prison ethnographers have tended to downplay the epistemological and methodological dilemmas relating to identity and positionality, which have been more commonly rehearsed in anthropological and sociological ethnographies. This paper explores these issues through a reflexive interrogation of a study of prisoner identities and social relations in two male prisons, with a particular focus on race/ethnicity, class and gender. Drawing from interactions with two prisoners as case studies, it applies Walkerdine et al.'s (2001) psycho-social analytical frame to illustrate how the subjectivities and biographies of researchers are implicated in the dynamics of prison research encounters and analysis. In doing so, it considers the epistemological implications of reflexive practice for interpreting the prison field. Source

Graham E.-J.,Open University
World Archaeology | Year: 2013

Votive deposits from Hellenistic and early Roman central Italy provide valuable evidence for the genuine concerns, fears and hopes of contemporary communities, including experiences and understandings of pregnancy, childbirth and infancy. This paper examines two types of terracotta votive - models of human uteri and swaddled infants - in order to elucidate the significance of the social and religious beginnings of life in ancient Italy. In particular, the study addresses the manner in which these states of being were perceived and produced by both parents and society at large through the treatment of the unborn/newborn body and its representation in the sanctuary. © 2013 Copyright Taylor and Francis Group, LLC. Source

Caprio C.,Open University | Caprio C.,National Research Council Italy | Baldini A.,National Research Council Italy | Baldini A.,University of Naples Federico II
Proceedings of the National Academy of Sciences of the United States of America | Year: 2014

T-box 1 (Tbx1), a gene encoding a T-box transcription factor, is required for embryonic development in humans and mice. Half dosage of this gene in humans causes most of the features of the DiGeorge or Velocardiofacial syndrome phenotypes, including aortic arch and cardiac outflow tract abnormalities. Here we found a strong genetic interaction between Tbx1 and transformation related protein 53 (Trp53). Indeed, genetic ablation of Trp53, or pharmacological inhibition of its protein product p53, rescues significantly the cardiovascular defects of Tbx1 heterozygous and hypomorphic mutants. We found that the Tbx1 and p53 proteins do not interact directly but both occupy a genetic element of Gbx2, which is required for aortic arch and cardiac outflow tract development, and is a known genetic interactor of Tbx1. We found that Gbx2 expression is down-regulated in Tbx1+/-embryos and is restored to normal levels in Tbx1+/-;Trp53+/-embryos. In addition, we found that the genetic element that binds both Tbx1 and p53 is highly enriched in H3K27 trimethylation, and upon p53 suppression H3K27me3 levels are reduced, along with Ezh2 enrichment. This finding suggests that the rescue of Gbx2 expression in Tbx1+/-;Trp53+/-embryos is due to reduction of repressive chromatin marks. Overall our data identify unexpected genetic interactions between Tbx1 and Trp53 and provide a proof of principle that developmental defects associated with reduced dosage of Tbx1 can be rescued pharmacologically. Source

Newman J.,Open University
Policy and politics | Year: 2013

This paper addresses the problem of how to engage with the politics of public policy in the current period of cuts, austerity and retrenchment. It explores current strategies of divestment, design and decentralisation, assessing the scope within each for creative enactments and alternative pathways. It then explores 'public-making' as a means of countering the affective consequences of austerity, and shows how practitioners mediate and manage the tensions that result through multiple forms of 'border work'. Finally the paper explores the troubled relationship between progressive policy enactments and neoliberal appropriations. © Policy Press 2013. Source

Wouters S.G.M.,Open University | Spek A.A.,Mental Health Institution GGZ Eindhoven
Research in Autism Spectrum Disorders | Year: 2011

The present study compared 21 high functioning individuals with autism, 21 individuals with schizophrenia and 21 healthy individuals in self-reported features of autism, as measured by the Autism-spectrum Quotient (AQ). The individuals with autism reported impairment on all AQ subscales, compared to the neurotypical group. The schizophrenia group reported deficits on all subscales except Attention to Detail, compared to the neurotypical group. The autism group reported more impairment than the individuals with schizophrenia in Social skill, Communication and Attention switching. © 2011 Elsevier Ltd. All rights reserved. Source

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