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Krasilenko V.G.,Open International University of Human Development Ukraine | Nikolskyy A.I.,Vinnitsa National Technical University | Krasilenko O.V.,National Aviation University | Nikolska M.A.,Vinnitsa National Technical University
Proceedings of SPIE - The International Society for Optical Engineering

The paper considers results of designing and modeling analogue-digital converters (ADC) with continuously logical functions (CLF), namely equivalently (nonequivalently) functions. Such ADC, named us complementary - dual equivalently (CDE ADC). Compared with usual converters, for example, reading, a bit-by-bit equilibration, and so forth, have a number of advantages: high speed and reliability, simplicity, small power consumption, the big degree of integration in linear and matrix files. The considered aspects of designing of CDE ADC in an initial binary code will be us Gray. Base digit cells of such CDE ADC, series-pipelined are connected in structures, consist from 23 CMOS the transistors, one-two photo diodes, have low (1,5-3,5) supply voltage, work in current modes with the maximum values of currents (10-40 μA). Therefore such new principles of realization high-speed low-discharge ADC have allowed, as have shown modeling experiments, to reach time of transformation less than 20-30 nS at 5-6 bits of a code Gray and the general power 1-5 mW. CDE ADC open new prospects for realization linear and matrix (with picture operands) micro photoelectronic structures which are necessary for neural networks, digital optoelectronic processors, neurofuzzy controllers, and so forth. © 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE). Source

Krasilenko V.G.,Open International University of Human Development Ukraine | Ogorodnik K.V.,Vinnitsa National Technical University | Nikolskyy A.I.,Vinnitsa National Technical University | Dubchak V.N.,Vinnitsa State Agrarian University
Proceedings of SPIE - The International Society for Optical Engineering

We consider design of hardware realizations of optoelectronic reconfigurable universal or multifunctional logical elements of two-valued logic with current inputs and current outputs on the basis of CMOS current mirrors and circuits which realize the limited difference functions. We show advantages of such elements consisting in encoding of Boolean variables by the photocurrent levels, that allows easily to provide optical inputs (by photodetectors) and optical outputs (by light-emitting devices). The conception of construction of the family of the offered optoelectronic photocurrent reconfigurable universal or multifunctional logical elements (OPR ULE) consists in the use of a current mirrors realized on 1.5μm or 0.35 μm technology CMOS transistors. Presence of 15-30 transistors, 1÷4 photodetectors makes the offered circuits quite compact and allows their integration in 1D and 2D arrays. In the presentation we consider the whole family of the offered circuits, show the simulation results and possible prospects of application of the circuits in particular for time-pulse coding for multivalued, continuous, neuro-fuzzy and matrix logics. The simulation results of the NOT, AND, OR, OR-NOT,XOR current logical elements and OPR ULE on the 1.5 μm or 0.35 μm technology CMOS transistors showed that the level of logical unit can change from 1 μA to 10 μA for low-power consumption variants and from 10 μA to 100 μA for high-speed variants. Signals delays, values of fronts and cutoffs at operation with impulse logical signals with 1uA logical unit are not exceed 70-140 ns and at operation with impulse logical signals with 100 μA logical unit are no more than 4-6 ns and the consumption power is 100-4000 μW. © 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE). Source

Polutrenko M.,Ivano Frankivsk National Technical University of Oil and Gas | Pilyashenko-Novokhatnyi A.,Open International University of Human Development Ukraine
Chemistry and Chemical Technology

The effect of industrially manufactured corrosion inhibitors ("G", "K", "L", "M", and "N" inhibitors) on the biological activity of thione (TB) and sulfate reducing (SRB) bacteria and corrosive microbial associations has been studied. SRB sensitivity to all the studied inhibitors has been established. The dynamics of hydrogenase reaction blocking under the action of the studied inhibitors as well as inhibition constants have been determined. Nitrogenated corrosion inhibitors are recommended to be used for protecting the subterranean metal structures from microbial corrosion. © Polutrenko M., Pilyashenko-Novokhatnyi A., 2013. Source

Kozachok M.V.,NASU Bogolyubov Institute for Theoretical Physics | Kozachok M.V.,Open International University of Human Development Ukraine | Lev B.I.,NASU Bogolyubov Institute for Theoretical Physics
Condensed Matter Physics

As an approach to the motion of particles in an anisotropic liquid, we analytically study the Stokes drag of spherical particles in a nematic liquid crystal. The Stokes drag of spherical particles for a general anisotropic case is derived in terms of multipoles. In the case of weak anchoring, we use the well-known distribution of the elastic director field around the spherical particle. In the case of strong anchoring, the multipole expansion may be also used by modifying the size of a particle to the size of the deformation coating. For the case of zero anchoring (uniformdirector field)we found that the viscosities along the director η{double pipe} and perpendicular direction η⊥ are almost the same, which is quite reasonable because in this case the liquid behaves as isotropic. In the case of non-zero anchoring, the general ratio η{double pipe} /η⊥ is about 2 which is satisfied by experimental observations.© M.V. Kozachok, B.I. Lev, 2014. Source

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.1.4-1 | Award Amount: 7.75M | Year: 2013

Reconstitution of immune system function in immunocompromised patients depends on the presence of a functional thymus, and specifically, on the diverse array of epithelial cells within the thymic stroma. The thymus is the first organ to degenerate in normal healthy individuals, and is also sensitive to cytotoxic interventions. Therefore lack of thymic function presents a serious problem for many patients. Transplantation of neonatal human thymus can lead to successful immune system reconstitution, but limited tissue supply prevents its widespread use. Thymic epithelial stem cells (TESC), which can generate all of the epithelial subpopulations of the adult thymus, present an alternative source of transplantable cells. However, protocols for growing or generating TESC in the laboratory have not yet been developed. This proposal aims to develop robust and scalable protocols for the long-term in vitro culture of functionally validated human TESC, including standardized quality controls, and to establish optimized means of delivering these cells to immunocompromised recipients such that thymus function is fully restored. It also aims to develop optimized procedures for cryopreservation of human thymic stromal cells. These objectives relate directly to the topic identified in call HEALTH.2013.1.4-1 Controlling differentiation and proliferation in human stem cells intended for therapeutic use. THYMISTEM brings together a strong, pan-European team comprising thymus and stem cell biologists, immunologists working in humanized mouse models, haematologists expert in immune reconstitution, tissue engineers, and experts in cryopreservation and cell banking, to deliver these goals. Overall, this work will build the preclinical foundations required for development of a novel stem-cell based therapy: transplantation of thymic epithelial stem cell-based organoids for regenerative recovery of thymic - and thus immune system - function in patients.

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