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Mir S.,COMSATS Institute of Information Technology | Asghar B.,Open-First | Khan A.K.,COMSATS Institute of Information Technology | Rashid R.,COMSATS Institute of Information Technology | And 3 more authors.
Journal of Polymer Engineering | Year: 2017

The objective of this study was to prepare linear low density polyethylene (LLDPE)/chitosan/closite nanocomposites by using various concentrations of LLDPE, chitosan, and closite clay mineral. The nanocomposites were then characterized for their thermal, mechanical, and rheological properties by using different analytical techniques including thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), rheological characterization, tensile strength study, and scanning electron microscopy. The TGA demonstrated that crosslinked composites are thermally more stable than non-crosslinked composites. The DSC stated that the percentage crystallinity of crosslinked composites is lower than the non-crosslinked composites. It is also observed that the increasing quantity of chitosan and closite also reduces the percentage crystallinity of the prepared nanocomposites. Rheological characterization revealed that, crosslinked composites are viscoelastic in nature and have high complex viscosities (η∗) and high dynamic shear storage modulus (G′), while non-crosslinked composites showed high dynamic shear loss modulus (G″). Tensile strength of crosslinked composites was much higher than non-crosslinked composites, however elongation at break (Eb) values of non-crosslinked composites are higher than crosslinked composites. The scanning electron microscopy displayed strong adhesion between matrix-filler-interphase in crosslinked composites, while some gaps were also observed in non-crosslinked composites. As a conclusion, chitosan, closite clay, and the LLDPE based nanocomposites with improved thermal, mechanical, and rheological properties can be successfully prepared by employing a peroxide-initiated melt compounding technique. © 2017 Walter de Gruyter GmbH, Berlin/Boston 2017.

Aznaurova Y.B.,Open-First | Zhumataev M.B.,Open-First | Roberts T.K.,Emory University | Aliper A.M.,Moscow Institute of Physics and Technology | Zhavoronkov A.A.,Open-First
Reproductive Biology and Endocrinology | Year: 2014

Endometriosis is a common and painful condition affecting women of reproductive age. While the underlying pathophysiology is still largely unknown, much advancement has been made in understanding the progression of the disease. In recent years, a great deal of research has focused on non-invasive diagnostic tools, such as biomarkers, as well as identification of potential therapeutic targets. In this article, we will review the etiology and cellular mechanisms associated with endometriosis as well as the current diagnostic tools and therapies. We will then discuss the more recent genomic and proteomic studies and how these data may guide development of novel diagnostics and therapeutics. The current diagnostic tools are invasive and current therapies primarily treat the symptoms of endometriosis. Optimally, the advancement of " -omic" data will facilitate the development of non-invasive diagnostic biomarkers as well as therapeutics that target the pathophysiology of the disease and halt, or even reverse, progression. However, the amount of data generated by these types of studies is vast and bioinformatics analysis, such as we present here, will be critical to identification of appropriate targets for further study. © 2014 Aznaurova et al.; licensee BioMed Central Ltd.

Shindyapina A.V.,Moscow Institute of Physics and Technology | Mkrtchyan G.V.,Moscow State University | Gneteeva T.,Open-First | Buiucli S.,Moscow Institute of Physics and Technology | And 6 more authors.
Rejuvenation Research | Year: 2014

Age-related metastatic mineralization of soft tissues has been considered a passive and spontaneous process. Recent data have demonstrated that calcium salt deposition in soft tissues could be a highly regulated process. Although calcification occurs in any tissue type, vascular calcification has been of particular interest due to association with atherosclerosis, chronic kidney disease (CKD), and osteoporosis. Different mechanisms underlying calcium apatite accumulation are explored with these age-related disorders. In the case of atherosclerotic plaques, oxy-lipids trigger release of the pro-inflammatory cytokines and inflammation that activate calcification processes in aorta intimae. In CKD patients, renal failure alters the balance between calcium and phosphate levels usually regulated by fibroblast growth factor-23 (FGF23), Klotho, and vitamin D, and vascular smooth muscle cells (VSMCs) begin to explore an osteoblastosteoblast-like phenotype. Calcification could affect extracellular matrix along with VSMCs. Collagen is a major component of extracellular matrix and its modifications accumulate with age. The formation of cross-links between collagen fibers is regulated by the action of lysine hydroxylases and lysyl oxidase and could occur spontaneously. Oxidation-induced advanced glycation end products (AGEs) are a major type of spontaneous cross-links that accelerate with age and may result in tissue stiffness, problems with recycling, and potential accumulation of calcium apatite. Applying strategies for clearing the AGEs proposed by de Grey may be more difficult in the highly mineralized extracellular matrix. We performed bioinformatic analysis of the molecular pathways underlying calcification in atherosclerotic and CKD patients, signaling pathways of collagen cross-links formation, and bone mineralization, and we propose new potential targets and review drugs for calcification treatment. © Copyright 2014, Mary Ann Liebert, Inc. 2014.

Tarcoveanu E.,Open-First
Chirurgia (Bucharest, Romania : 1990) | Year: 2011

The classic apprenticeship model for surgical training takes place into the operating theater under the strict coordination of a senior surgeon. During the time and especially after the introduction of minimally invasive techniques as gold standard treatment for many diseases, other methods were developed to successful fulfill the well known three stages of training: skill-based behavior, rule-based behavior and knowledge-based behavior. The skills needed for minimally invasive surgery aren't easily obtained using classical apprenticeship model due to ethical, medico-legal and economic considerations. In this way several types of simulators have been developed. Nowadays simulators are worldwide accepted for laparoscopic surgical training and provide formative feedback which allows an improvement of the performances of the young surgeons. The simulators currently used allow assimilating only skill based behavior and rule-based behavior. However, the training using animal models as well as new virtual reality simulators and augmented reality offer the possibility to achieve knowledge-based behavior. However it isn't a worldwide accepted laparoscopic training curriculum. We present our experience with different types of simulators and teaching methods used along the time in our surgical unit. We also performed a review of the literature data.

Zhavoronkov A.,Biogerontology Research Foundation | Zhavoronkov A.,Open-First | Cantor C.R.,National Research Nuclear University MEPhI | Cantor C.R.,University of California at Irvine | Cantor C.R.,Sequenom
Rejuvenation Research | Year: 2013

We developed a new model for initiating, coordinating, funding, and managing biomedical research projects. The concept involves engaging the patients with chronic conditions with no known cures into goal-oriented research activities. In this model, the patient seeks the help of a research organization to bring together a multidisciplinary team of research scientists and physicians to initiate research projects using the patient's grant funding, samples, as well as the management expertise. This model may be of interest to other research institutions because it has many benefits, including new sources of private research funding, when government funding is getting scarce, motivating scientists and physicians to work closely together on goal- and patient-oriented research projects, and using patients' management skills. © 2013, Mary Ann Liebert, Inc.

News Article | July 15, 2010

A recent developer survey from Open-First reveals that Nokia’s Ovi Store is lagging in several key areas with nearly 20 percent of the participants unlikely to use Nokia’s app store in the future. Although the majority of developers surveyed will continue to support Nokia’s ecosystem, more than 42 percent said Ovi is below average when compared to other app stores, such as those from Apple and Google. These responses indicate that Nokia doesn’t only have to play catch up with its smartphone operating system strategy, but also with the marketplace that’s helping to power device sales. The survey results — available online through a Scribd document — indicate that Nokia is flagging in the areas of Quality Assurance and support communications. A full 40 percent of developers were less than “somewhat satisfied” in the overall submission and publication process used to get an app in the Ovi store, saying the process is complicated and too lengthy. Worse, a point I’ve made in the past: With so many Nokia handset devices, developers struggle in the management and selection of supported devices. Some developer quotes highlight the focus points that Nokia’s Ovi Store is contending with: To be fair, developers have voiced similar or related complaints with Apple’s own iTunes App Store process. And Google’s Android Market has room for improvement as well. The main difference though is that both of those platforms have sales momentum in the high-end smartphone segment that Nokia currently lacks. Both platforms are eating away at Nokia’s market share. That aspect could partially explain why 70 percent of Ovi Store developers in the survey are creating software for stores other than Nokia. Nokia is touting plenty of easy app development methods through web standards and the Qt cross-platform framework, but high smartphone sales can lead to high software sales. Another reason devs aren’t monogamous with Nokia is the lower-than-expected return on creating software for Nokia devices: 80.7 percent of developers are earning less than they expected. Not every developer on Apple or Google devices is a success story either, but when you combine lagging handset sales and a reactionary smartphone strategy with an app store that needs development in its own right, developers are wise to hedge their bets. I wish the survey asked whether it would matter to developers if Nokia adopted Android for smartphones going forward. I think it would, for the sales momentum reason alone. Even though the Android Market is far from perfect, it currently looks to be the only challenger to Apple’s software store.

Open-First | Entity website

CURRENT CLIENTS Alcatel-Lucent, AVG, Hersheys, Joikusoft, Merck, Plantronics, Posit-Science, PAST CLIENTS BestBuy, NYSE, Riverbed, Symbian, University of Phoenix, Volvo Group (also through The Conversation Group) DATA AND DEVELOPERS Developer Platform Open-First is helping Alcatel-Lucent build a suite of tools to provide end-to-end application and API developer life-cycle support. The tools include a cloud based technology suite that enables application developers to build, test, manage and publish their apps and APIs ...

Open-First | Entity website

Ted Shelton Co-Founder and CEO The future of marketing is about being the inspirational enablers and leaders of a whole new generation of business people who are going to be deeply engaged with their markets. more Eoin Russell Co-Founder and Partner More and more, online engagement has less and less to do with destinations ...

Open-First | Entity website

Ted Shelton Co-Founder and CEO The future of marketing is about being the inspirational enablers and leaders of a whole new generation of business people who are going to be deeply engaged with their markets. more Eoin Russell Co-Founder and Partner More and more, online engagement has less and less to do with destinations ...

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