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Oniris and Nantes University Hospital Center | Date: 2017-05-17

The present invention relates to the use of insulin-producing cells encapsulated in silanized hydroxypropyl methylcellulose (Si-HPMC) for the treatment of type 1 diabetes. Methods and kits are also provided for restoring and/or maintaining euglycemia in type 1 diabetic patients and in type 1 prediabetic patients.

The present invention relates to microRNAs (miR-7a, miR-215 and miR-375) for use in the in vitro diagnosis of insulitis and the in vitro prognosis of future type 1 diabetes development. The invention also relates to miR-specific primers and probes, kits comprising these primers and/or probes, and in vitro methods of diagnosis and prognosis using these primers and/or probes. Also provided are methods for assessing the effectiveness of a therapeutic treatment for insulitis or of a treatment for preventing type 1 diabetes onset, as well as methods of screening for candidate compounds potentially useful in the treatment for insulitis or in the prevention of type 1 diabetes onset.

Tessier C.,ONIRIS | Bruhschwein A.,Ludwig Maximilians University of Munich | Lang J.,Vetsuisse Faculty Bern | Konar M.,MR Support Service | And 2 more authors.
Veterinary Radiology and Ultrasound | Year: 2013

Diseases of paranasal sinuses and nasal passages in horses can be a diagnostic challenge because of the complex anatomy of the head and limitations of many diagnostic modalities. Our hypothesis was that magnetic resonance (MR) imaging would provide excellent anatomical detail and soft tissue resolution, and would be accurate in the diagnosis of diseases of the paranasal sinuses and nasal passages in horses. Fourteen horses were imaged. Inclusion criteria were lesions located to the sinuses or nasal passages that underwent MR imaging and subsequent surgical intervention and/or histopathologic examination. A low field, 0.3 tesla open magnet was used. Sequences in the standard protocol were fast spin echo T2 sagittal and transverse, spin echo T1 transverse, short-tau inversion recovery (STIR) dorsal, gradient echo 3D T1 MPR dorsal (plain and contrast enhanced), spin echo T1 fatsat (contrast enhanced). Mean scan time to complete the examination was 53 min (range 39-99 min). Lesions identified were primary or secondary sinusitis (six horses), paranasal sinus cyst (four horses), progressive ethmoid hematoma (two horses), and neoplasia (two horses). The most useful sequences were fast spin echo T2 transverse and sagittal, STIR dorsal and FE3D MPR (survey and contrast enhanced). Fluid accumulation, mucosal thickening, presence of encapsulated contents, bone deformation, and thickening were common findings observed in MR imaging. In selected horses, magnetic resonance imaging is a useful tool in diagnosing lesions of the paranasal sinuses and nasal passages. © 2012 Veterinary Radiology & Ultrasound.

Schoebitz M.,ONIRIS | Schoebitz M.,Austral University of Chile | Simonin H.,ONIRIS | Poncelet D.,ONIRIS
Journal of Microencapsulation | Year: 2012

This work deals with optimising the cell survival of rhizobacteria encapsulated in alginate beads filled with starch. Immobilisation of rhizobacteria was done by dripping alginate-starch solution mixed with rhizobacteria into a calcium solution. Beads were analysed based on matrix formulation, bacteria growth phase, osmoprotectants and nature of calcium solution. Maximum cell recovery was obtained on Raoultella terrigena grown in medium supplemented with trehalose and calcium gluconate as gelling agent. Furthermore, dried beads containing Azospirillum brasilense presented 76 of viable cells after one year of storage. The survival of rhizobacteria during the bioencapsulation process can be improved by incorporating starch on beads composition, varying the growth phase of cells and using trehalose in growth culture medium. This work provides a selection of appropriate methods to improve the surviving rate of encapsulated cells during their production and long-term storage (∼1 year at 4°C). © 2012 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Rousseliere D.,Agrocampus Ouest | Rousseliere S.,Oniris
Public Understanding of Science | Year: 2017

The study of European attitudes toward biotechnologies underlines a situation that is relatively contrasting in Europe. However, as different effects of time can influence the social attitudes (a life-cycle effect, a generational effect, and an exogenous temporal effect potentially affecting the entire population), an appropriate methodology should be used. To this end, age-period-cohort-country models have thus been estimated based on Eurobarometer data from 1991 onward. Applied to different data subsets, these models give similar results underlining the importance of the life-cycle effects as well as the heterogeneity of the link between political affiliation and biotechnologies attitudes across the European countries. © 2016, © The Author(s) 2016.

Anon M.C.,Research Center sarrollo En Criotecnologia Of Alimentos | De Lamballerie M.,ONIRIS | Speroni F.,Research Center sarrollo En Criotecnologia Of Alimentos
Innovative Food Science and Emerging Technologies | Year: 2011

In the present work the effect of high pressure (HP) treatment in the presence of NaCl on the thermal behavior of soybean proteins was analyzed by differential scanning calorimetry. The thermograms obtained have shown that NaCl addition increased the thermal stability - increase in temperatures of denaturation (Td) - of both glycinin and β-conglycinin. HP treatments increased thermal stability of glycinin, but decreased that of β-conglycinin. High NaCl concentrations decreased (in glycinin) or inverted (in β-conglycinin) the effects of HP on thermal stability. Cooperativity of denaturation of glycinin was enhanced by NaCl and HP. Cooperativity of denaturation of β-conglycinin was enhanced by HP and also by NaCl at 0.2 mol/L but decreased with the combination of treatments. Salt addition increased the enthalpy, ΔH, of denaturation of glycinin and β-conglycinin, being this effect stronger on glycinin. HP treatment provoked the denaturation of both protein fractions. The presence of NaCl protected glycinin against HP-denaturation at any assayed salt concentration and pressure level, while β-conglycinin was only protected at 200 and 400 MPa, but was more denaturated at 600 MPa in the presence of 0.6 mol/L of NaCl. Industrial relevance: The knowledge provided by this work may be useful in the handling of high pressure-treated food with high NaCl content (e.g. meat emulsions, smallgoods) where soybean proteins are used as additives, in order to choose high pressure values to achieve their denaturation or predict the effects of ulterior thermal treatments. Thus, this knowledge may be useful to increase the use of high pressure in food industry. © 2011 Elsevier Ltd. All rights reserved.

Le Velly R.,Montpellier SupAgro | Dufeu I.,Oniris
Journal of Rural Studies | Year: 2016

The aim of this article is to show Actor-Network Theory's (ANT) potential for accounting for the alternative-conventional hybridity of alternative food networks. A review of the literature shows that this has not yet been done. Consequently, this article proposes to fill this gap with findings from ANT research regarding such notions as "market devices," "market mediation," and "market agencements." The theory is backed up by an analysis of a local food system involving five small fishermen and the delivery of fish to 1500 households in the area around Nantes in France. Seeing this local food system as a "market agencement," i.e., a sociotechnical arrangement capable of market action, makes it possible to underscore the many hybridities that compose alternative food networks: those of human, material, and natural entities; the local and global scales; and production and consumption; but also that of alternative and conventional actors and devices. © 2015 Elsevier Ltd.

Blancou P.,ONIRIS
Methods in molecular biology (Clifton, N.J.) | Year: 2011

Heme oxygenase-1 (HO-1) is one of the three isoforms of the heme oxygenase enzyme that catabolyzes the degradation of heme into biliverdin with the production of free iron and CO. HO-1 is induced by its substrate and by other stimuli, including agents involved in oxidative stress and proinflammatory cytokines as well as several anti-inflammatory stimuli. A growing body of evidence points toward the capacity of this molecule to inhibit immune reactions and the pivotal role of HO-1 in inflammatory diseases. We will first review the physiological role of HO-1 as determined by the analysis of HO-1-deficient individuals. This will be followed by an examination of the effect of HO-1 within immunopathological contexts such as immune disorders (autoimmunity and allergy) or infections. A section will be devoted to the use of an HO-1 inducer as an immunosuppressive molecule in transplantation. Finally, we will review the molecular basis of HO-1 actions on different immune cells.

The invention relates to a strain of Lactobacillus sakei called Lactobacillus sakei LHIS2885 strain, and to a strain derived from L. sakei LHIS2885. The invention also relates to the use of a strain of L. sakei, preferably the strain LHIS2885 or a strain derived from LHIS2885, for the preservation of food products, preferably products from the sea.

Bite trays (10, 11) having lateral cylindrical pivots (30) articulating two connecting rods (20) in propulsion, the front fastening elements (30a) operate according to a transverse elastic click-lock system and the rear connecting-rod fastening elements (30b) operate according to an open-ring radial locking system, in order to increase the operating safety under all circumstances.

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