Oncquest Laboratory

Delhi, India

Oncquest Laboratory

Delhi, India

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Jha S.,University of Delhi | Jha S.,Maulana Azad Medical College | Kumar D.,Maulana Azad Medical College | Kaul J.M.,Maulana Azad Medical College | And 4 more authors.
Journal of the Anatomical Society of India | Year: 2017

Introduction: Acute lymphoblastic leukemia (ALL) comprises about 70-80% of childhood leukemia. The present work was undertaken to study the spectrum of chromosomal abnormalities in North Indian population in haematologically confirmed pediatric ALL patients using bone marrow aspirates. Material and methods: Bone marrow aspirates (0.6. ml) after adding 15. ml RPMI medium were divided into three parts for immediate culture, 24. h culture and 48. h culture method, were incubated according to their respective time duration and karyotyping was done. Results: Out of 20 cases results were obtained in 14 cases. Out of these 9 cases (64.2%) in present study belonged to hypodiploid group. Trisomy was found in 3 (21.42%) cases and polyploidy in 1 (7.1%) case. Three year old male patient showed translocation t (21; 4) with deletion of long arm of chromosome 5 and absence of 7, 11, 12 and Y chromosomes. 4 Year old male patient showed translocation involving chromosome 13 with absence of chromosomes 7, 10, 11 and 12.5. year old male patient showed one dicenteric 5 chromosome with additional copies of chromosomes 6, 8, 9, 21 and 22. Discussion: Numerical and structural chromosomal abnormalities found in Acute Lymphoblastic Leukemia have prognostic significance. Review of world literature shows that there is geographical variation in ploidy pattern of ALL. Our findings will help to play a key role in risk stratification and treatment protocols considering the genetic diversity of pediatric ALL in North Indian population. © 2017 Anatomical Society of India.


Kunal S.,University of Delhi | Pilaniya V.,University of Delhi | Jain S.,Oncquest Laboratory | Shah A.,University of Delhi
BMJ Case Reports | Year: 2016

Organising pneumonia ( OP) is a distinct but uncommon entity with characteristic clinicoradiological features and histological findings. When the aetiology of OP remains unknown, it is termed as cryptogenic OP (COP). COP is seen in the majority of patients with OP and usually observed in non/former smokers. A 54-year-old man, a smoker, presented with breathlessness, cough and mucoid sputum. Imaging demonstrated unilateral 'Crazy-paving' pattern in the left upper lobe and left-sided effusion. In addition, paraseptal emphysema and left lower lobe bullae along with very severe obstructive ventilatory defect and impaired diffusion suggested chronic obstructive pulmonary disease (COPD). Transbronchial biopsy was suggestive of OP. In the absence of a definite aetiology, a diagnosis of COP associated with COPD was established. COP presenting as a unilateral 'Crazy-paving' pattern is yet to be documented. To the best of our knowledge, this is the first detailed description of COP presenting as unilateral 'Crazy-paving' pattern associated with COPD. ©2016 BMJ Publishing Group. All rights reserved.


Joseph P.,Mohan Dai Oswal Hospital | Goyal R.,Mohan Dai Oswal Hospital | Bansal P.,Mohan Dai Oswal Hospital | Parmar R.,Oncquest Laboratory | Dutt S.,Oncquest Laboratory
Journal of Clinical and Diagnostic Research | Year: 2015

Gastrointestinal stromal tumours (GIST) are the most common mesenchymal neoplasms located in the alimentary tract. Stromal tumours that arise outside the gastrointestinal tract as primary tumour are designated as extra-gastrointestinal stromal tumours (EGIST). The EGIST are located in mesentry, omentum, retroperitoneum and rarely in pancreas. Only 19 cases of pancreatic EGIST (pEGIST) have been reported in the literature. Of these, there were only two cases of pEGIST with documentation of molecular alteration in C-Kit gene. We here report a third case of primary pEGIST with documentation of C-kit mutation. © 2015, Journal of Clinical and Diagnostic Research. All right reserved.


PubMed | Oncquest Laboratory and University of Delhi
Type: | Journal: BMJ case reports | Year: 2016

Organising pneumonia (OP) is a distinct but uncommon entity with characteristic clinicoradiological features and histological findings. When the aetiology of OP remains unknown, it is termed as cryptogenic OP (COP). COP is seen in the majority of patients with OP and usually observed in non/former smokers. A 54-year-old man, a smoker, presented with breathlessness, cough and mucoid sputum. Imaging demonstrated unilateral Crazy-paving pattern in the left upper lobe and left-sided effusion. In addition, paraseptal emphysema and left lower lobe bullae along with very severe obstructive ventilatory defect and impaired diffusion suggested chronic obstructive pulmonary disease (COPD). Transbronchial biopsy was suggestive of OP. In the absence of a definite aetiology, a diagnosis of COP associated with COPD was established. COP presenting as a unilateral Crazy-paving pattern is yet to be documented. To the best of our knowledge, this is the first detailed description of COP presenting as unilateral Crazy-paving pattern associated with COPD.


PubMed | Oncquest Laboratory and Mohan Dai Oswal Hospital
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2015

Gastrointestinal stromal tumours (GIST) are the most common mesenchymal neoplasms located in the alimentary tract. Stromal tumours that arise outside the gastrointestinal tract as primary tumour are designated as extra-gastrointestinal stromal tumours (EGIST). The EGIST are located in mesentry, omentum, retroperitoneum and rarely in pancreas. Only 19 cases of pancreatic EGIST (pEGIST) have been reported in the literature. Of these, there were only two cases of pEGIST with documentation of molecular alteration in C-Kit gene. We here report a third case of primary pEGIST with documentation of C-kit mutation.

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