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Karakus N.,Gaziosmanpasa University | Kara N.,Ondokuz Mayis University | Ulusoy A.N.,Ondokuz Mayis University | Ozaslan C.,Oncology Research and Training Hospital | And 2 more authors.
Oncology Research and Treatment

Polymorphisms of estrogen synthesis-and adiposity-related genes can contribute to the development of breast cancer. The purpose of the current study was to analyze the association between CYP17A1 T27C (rs743572) and LEP-2548G>A (rs7799039) gene polymorphisms and breast cancer. Material and Methods: 199 breast cancer patients and 197 healthy controls were included in the study. The CYP17A1 and LEP gene polymorphisms were determined using polymerase chain reaction-based restriction fragment length polymorphism analysis. Results: No statistically significant association was found between these polymorphisms and breast cancer risk among a Turkish population. However, stratified analysis of these polymorphisms in relation to different clinicopathological characteristics of breast cancer revealed an association between breast cancer diagnosis and the CYP17A1 T27C polymorphism (p = 0.024). Conclusion: Our study suggests no strong association between the CYP17A1 T27C and LEP-2548G>A polymorphisms and the incidence of breast cancer in Turkish women. The potential association between CYP17A1 T27C and the type of breast cancer deserves further consideration. © 2015 S. Karger GmbH, Freiburg. Source

Caglar E.,Oncology Research and Training Hospital | Aribas B.,Oncology Research and Training Hospital | Tiken R.,Oncology Research and Training Hospital | Keskin S.,University of Konya
BMJ Case Reports

In patients presenting with abdominal pain, appendicitis is the most common surgical disorder. Appendicitis causing pain in the left lower quadrant is extremely rare and can occur with congenital abnormalities that include true left-sided appendix or as an atypical presentation of right-sided long appendix, which projects into the left lower quadrant. We report a case of a 69-year-old man showing midgut malrotation with acute appendicitis presenting as left lower quadrant abdominal pain. Copyright 2014 BMJ Publishing Group. All rights reserved. Source

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