Oncology Service

Sabadell, Spain

Oncology Service

Sabadell, Spain
SEARCH FILTERS
Time filter
Source Type

PubMed | Federal University of Rio Grande do Sul, Bioethics Research Laboratory, Oncology Service, Pediatric Oncology Service and 5 more.
Type: Journal Article | Journal: Revista da Associacao Medica Brasileira (1992) | Year: 2015

cancer is the second leading cause of death in children between the ages of 0 and 14 years, corresponding to approximately 3% of all cases diagnosed in Brazil. A significant percentage (5-10%) of pediatric cancers are associated with hereditary cancer syndromes, including Li-Fraumeni/Li-Fraumeni-like syndromes (LFS/LFL), both of which are caused by TP53 germline mutations. Recent studies have shown that a specific TP53 mutation, known as p.R337H, is present in 1 in 300 newborns in Southern and Southeast Brazil. In addition, a significant percentage of children with LFS/LFL spectrum tumors in the region have a family history compatible with LFS/LFL.to review clinical relevant aspects of LFS/LFL by our multidisciplinary team with focus on pediatric cancer.the NCBI (PubMed) and SciELO databases were consulted using the keywords Li-Fraumeni syndrome, Li-Fraumeni-like syndrome and pediatric cancer; and all manuscripts published between 1990 and 2014 using these keywords were retrieved and reviewed.although LFS/LFL is considered a rare disease, it appears to be substantially more common in certain geographic regions. Recognition of population- specific risks for the syndrome is important for adequate management of hereditary cancer patients and families. In Southern and Southeastern Brazil, LFS/ LFL should be considered in the differential diagnosis of children with cancer, especially if within the spectrum of the syndrome. Due to the complexities of these syndromes, a multidisciplinary approach should be sought for the counseling, diagnosis and management of patients and families affected by these disorders. Pediatricians and pediatric oncologists in areas with high prevalence of hereditary cancer syndromes have a central role in the recognition and proper referral of patients and families to genetic cancer risk evaluation and management programs.


PubMed | University of Lausanne, Oncology Service, Ophthalmology Service, Instituto Nacional Of Ciencias Medicas Y Nutricion Salvador Zubiran and Radiology and Imaging Service
Type: Journal Article | Journal: Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion | Year: 2016

Intra-arterial chemotherapy is a novel therapeutic modality for retinoblastoma patients. Intra-arterial chemotherapy involves the administration of a super-selective drug through the ophthalmic artery, resulting in better ocular penetration and low systemic toxicity.The aim of this report was to evaluate the feasibility of intra-arterial chemotherapy in a large referral center in Mexico City.We included patients with bilateral retinoblastoma, one enucleation, and active disease in the other eye after at least two courses of systemic chemotherapy combined with topical treatments. All patients were treated with three courses of a combination of melphalan 4 mg and topotecan 1 mg. Patients were examined under general anesthesia three weeks after each chemotherapy cycle.From 14 eligible patients, three could not be treated due to inaccessibility of the ophthalmic artery. A complete response was observed in 5/11 patients, three in Stage C according to the International Classification for Intraocular Retinoblastoma, one in Stage D, and one in Stage B. The eyes of three patients were enucleated as a result of active/progressive disease, one in Stage B and two in Stage D. Eye preservation was 55% after a mean follow-up of 171 days (range 21-336).Super-selective intra-arterial chemotherapy is safe and effective for preventing the enucleation of 55% of affected eyes in this group of patients.


Blanco R.,Oncology Service | Maestu I.,Hospital Universitario Dr Peset | de la Torre M.G.,Lilly Spain | Cassinello A.,Lilly Spain | Nunez I.,Lilly Spain
Annals of Oncology | Year: 2015

Most patients with non-small-cell lung cancer (NSCLC) are elderly but evidence to guide appropriate treatment decisions for this age group is generally scant. Careful evaluation of the elderly should be undertaken to ensure that treatment appropriate for the stage of the tumour is guided by patient characteristics and not by age. The Comprehensive Geriatric Assessment (CGA) remains the preferred option, but briefer tools may be appropriate to select patients for further evaluation. The predicted outcome should be used to guide management decisions together with a reappraisal of polypharmacy. Patient expectations should also be taken into account. Management recommendations are generally similar to those of general guidelines for the NSCLC population, although the risks of surgery and toxicity of chemotherapy and radiotherapy are often increased in the elderly compared with younger patients; therefore, patients should be closely scrutinised and subjected to a CGA to ensure suitability of the planned treatment. If surgery is indicated, then lobectomy is generally the preferred option, although limited resection may be more feasible for some. Radiotherapy with curative intent is an alternative, with stereotactic body radiotherapy the most likely preferred modality. Adjuvant chemotherapy is also an appropriate approach, whereas adjuvant radiotherapy is generally not recommended. Concurrent chemoradiotherapy should be considered for elderly patients with inoperable locally advanced disease and chemotherapy for advanced/metastatic disease. Efforts should also be made to increase participation of elderly patients with NSCLC in clinical trials, thereby enhancing evidence-based treatment decisions for this majority group. This will require overcoming barriers relating to trial design and to physician and patient awareness and attitudes. © The Author 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology.


Ikonomi M.,Histopathology Laboratory | Cela B.,Histopathology Laboratory | Tarifa D.,Oncology Service
Macedonian Journal of Medical Sciences | Year: 2015

BACKGROUND: The recognition, terminology used and histopathologic evaluation of two essential elements in gastric carcinogenesis, atrophy and dysplasia, are characterized by controversy. MATERIALS AND METHODS: One hundred fifteen cases, with slides and their histopathologic reports from the archive of the Laboratory of Pathology were studied for the diagnostic value, reporting of dysplasia, interobserver variability, the relation of dysplastic lesions with inflammation, atrophy and metaplasia. After retrospectively studying the histopathologic reports from the archive we distributed the cases according to endoscopic and histopathologic diagnosis, together with the reexamination of the slides. The comparison of the median values of the numeric variables was made with the Mann-Whitney test (non-parametric equivalent of the Student’s “t” test). RESULTS: The endoscopic clinical diagnosis were: malignancy/suspicious for malignancy 88 cases (76%) and non-neoplastic diagnosis (like ulcer or gastritis) 27 cases (24%). From the reexamination of the cases it resulted that there is no difference in reporting the malignancy, but there is a difference in the cases reported as dysplasia (p = 0.001) and negative for neoplasia (p = 0.063, borderline). CONCLUSION: Clinicians and pathologists can feel directly the discrepancy called “interobserver variability” and should be assured that the use of guidelines will cause a lowering of this variability © 2015 Majlinda Ikonomi, Blerina Cela, Dhurata Tarifa.


PubMed | Oncology Service, University Pompeu Fabra, Pathology Service, Hospital Universitari Of Bellvitge and 3 more.
Type: Journal Article | Journal: Oncotarget | Year: 2016

Brain metastasis is a devastating problem in patients with breast, lung and melanoma tumors. GRP94 and FN14 are predictive biomarkers over-expressed in primary breast carcinomas that metastasized in brain. To further validate these brain metastasis biomarkers, we performed a multicenter study including 318 patients with breast carcinomas. Among these patients, there were 138 patients with metastasis, of whom 84 had brain metastasis. The likelihood of developing brain metastasis increased by 5.24-fold (95%CI 2.83-9.71) and 2.55- (95%CI 1.52-4.3) in the presence of FN14 and GRP94, respectively. Moreover, FN14 was more sensitive than ErbB2 (38.27 vs. 24.68) with similar specificity (89.43 vs. 89.55) to predict brain metastasis and had identical prognostic value than triple negative patients (p < 0.0001). Furthermore, we used GRP94 and FN14 pathways and GUILD, a network-based disease-gene prioritization program, to pinpoint the genes likely to be therapeutic targets, which resulted in FN14 as the main modulator and thalidomide as the best scored drug. The treatment of mice with brain metastasis improves survival decreasing reactive astrocytes and angiogenesis, and down-regulate FN14 and its ligand TWEAK. In conclusion our results indicate that FN14 and GRP94 are prediction/prognosis markers which open up new possibilities for preventing/treating brain metastasis.


PubMed | Histopathology Laboratory and Oncology Service
Type: Journal Article | Journal: Open access Macedonian journal of medical sciences | Year: 2016

The recognition, terminology used and histopathologic evaluation of two essential elements in gastric carcinogenesis, atrophy and dysplasia, are characterized by controversy.One hundred fifteen cases, with slides and their histopathologic reports from the archive of the Laboratory of Pathology were studied for the diagnostic value, reporting of dysplasia, interobserver variability, the relation of dysplastic lesions with inflammation, atrophy and metaplasia. After retrospectively studying the histopathologic reports from the archive we distributed the cases according to endoscopic and histopathologic diagnosis, together with the reexamination of the slides. The comparison of the median values of the numeric variables was made with the Mann-Whitney test (non-parametric equivalent of the Students t test).The endoscopic clinical diagnosis were: malignancy/suspicious for malignancy 88 cases (76%) and non-neoplastic diagnosis (like ulcer or gastritis) 27 cases (24%). From the reexamination of the cases it resulted that there is no difference in reporting the malignancy, but there is a difference in the cases reported as dysplasia (p = 0.001) and negative for neoplasia (p = 0.063, borderline).Clinicians and pathologists can feel directly the discrepancy called interobserver variability and should be assured that the use of guidelines will cause a lowering of this variability.


News Article | December 2, 2016
Site: en.prnasia.com

LONDON, Dec. 2, 2016 /PRNewswire/ -- Australian medtech startup 4Dx is making a bold foray into the global respiratory diagnostics marketplace after strong support from the U.S, U.K and Australian investment community.  Their AU$4M Series A investment round is set to close, oversubscribed, on December 9th after the inking of deals with major U.S hospitals and expanding relationships with key U.K medical institutions. 4Dx has developed unique software that generates moving, ultra-high-resolution images of motion and airflow in lung tissue. This revolutionary technology enables clinicians to view and measure abnormal lung function at the earliest stages of disease in a way that has not previously been possible. 4Dx technology is non-invasive and will have a major impact on the way medical professionals are able to diagnose and treat patients with diseases of the lung. 4Dx has also established formal clinical partnerships with several of the biggest and most advanced hospitals in the US, including Cedars-Sinai, The Cleveland Clinic, Children's Hospital Los Angeles, and the University of North Carolina at Chapel Hill. The company has also announced the appointment of Dr Bob Figlin to the 4Dx board from December 1st. Dr Figlin is Deputy Director of the Integrated Oncology Service Line, and Deputy Director at the Samuel Oschin Comprehensive Cancer Institute, part of the world-renowned Cedars-Sinai Medical Center in Los Angeles. He is also Director of the Hematology Oncology Division at the institute. Dr Figlin says, "4Dx has developed some of the most promising and exciting technology I've ever seen in the fight against disease. It will be a privilege to be able to use my medical and business experience to assist the company through this phase of its growth." Dr Figlin previously co-founded biotechnology company Agensys, which later sold as part of a nine-figure deal. 4Dx founder and chair Andreas Fouras, says, "Dr Figlin brings unparalleled experience and expertise in cancer therapies to 4Dx, where enhanced cancer treatment is among our first priorities. He also brings a vast medical knowledge and adds enormous capacity to our board's business decision making capacity." 4Dx is using investment monies to finance further clinical studies in addition to its first FDA submission, expected in Q1 2017. The AU$4M series A is open for investment in Australia and has also received strong interest from U.S and U.K markets, and will close on the 19th December. The company anticipates the raise will be over-subscribed. An additional round of fundraising is also planned for Q1 2017. About 4Dx: 4Dx is a software company aiming to deliver the global gold standard in respiratory diagnostics for all lung disorders, including, asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis and cancer. The unique 4Dx technology accurately and quickly scans lung function as the patient breathes, to provide sensitive, early diagnosis and to monitor changes over time. Our Software-as-a-Service scans deliver much more complete results, showing the subtlest variations in lung function down to the finest details, using lower levels of radiation than traditional methods. Respiratory diagnosis is a AU$40 billion p.a global industry that 4Dx aims to disrupt and grow through technology that provides clinicians with greater insights into diseases of the lung. 4Dx will bring about a step change in lung health by providing better information to doctors and patients. Better information means better decisions, and better outcomes.


News Article | November 30, 2016
Site: www.prnewswire.co.uk

Australian technology start-up 4DX has attracted one of the biggest names in global oncology as its latest Board member. LONDON, Nov. 30, 2016 /PRNewswire/ -- Robert A. Figlin, MD, FACP, joins the 4Dx board on December 1st.  Dr Figlin is Deputy Director of the Integrated Oncology Service Line. He also serves as the Deputy Director at the Samuel Oschin Comprehensive Cancer Institute, part of the world-renowned Cedars-Sinai Medical Center in Los Angeles and is Director of the Hematology Oncology Division at the institute, where he is in charge of integrating research and clinical strategies across all the Cedars-Sinai campuses. Since his arrival at Cedars- Sinai, he established the Experimental Therapeutics Program and successfully recruited clinical research staff in critical specialty areas such as breast cancer, bone marrow transplant, gastrointestinal oncology, genitourinary oncology, survivorship, and cancer biology. Dr Figlin says, "4Dx has developed some of the most promising and exciting technology I've ever seen in the fight against disease. It will be a privilege to be able to use my medical and business experience to assist the company through this phase of its growth." Dr Figlin co-founded Agensys - an early stage biotechnology company focussed on developing novel therapies for cancer.  The company has since been sold to Astellas Pharmaceuticals as part of a nine-figure deal. 4Dx founder and chair, Andreas Fouras, says, "Bob Figlin brings unparalleled experience and expertise in cancer therapies to 4Dx, where enhanced cancer treatment is among our first priorities. Bob brings a vast medical knowledge and adds enormous capacity to our board's business decision making capacity." Lung cancer is the biggest killer of all cancers and the current standard treatments of chemotherapy and radiotherapy have devastating effects on the lungs. 4Dx technology is non-invasive and will positively impact the way medical professionals are able to diagnose, and treat their patients. "4Dx is undergoing significant acceleration and is thrilled to have a clinician, researcher and entrepreneurial thinker in Bob Figlan join our team." "This revolutionary technology and the development of unique software to generate moving, ultra-high-resolution images of motion and airflow in lung tissue enables clinicians to view and measure abnormal lung function at the earliest stages of disease in a way that has not been possible before now." As well as their association with Cedars- Sinai, 4Dx has also created partnerships with other leading hospitals such as the Cleveland Clinic and the Children's Hospital Los Angeles in the US, and The Alfred and Peter Mac in Australia. About 4Dx: 4Dx is a software company aiming to deliver the global gold standard in respiratory diagnostics for all lung disorders, including, asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis and cancer. The unique 4Dx technology accurately and quickly scans lung function as the patient breathes, to provide sensitive, early diagnosis and to monitor changes over time. Our Software-as-a-Service scans deliver much more complete results, showing the subtlest variations in lung function down to the finest details, using lower levels of radiation than traditional methods. Respiratory diagnosis is a $25 billion p.a global industry that 4Dx aims to disrupt and grow through technology that provides clinicians with greater insights into diseases of the lung. 4Dx will bring about a step change in lung health by providing better information to doctors and patients.


News Article | December 2, 2016
Site: www.prnewswire.co.uk

LONDON, Dec. 2, 2016 /PRNewswire/ -- Australian medtech startup 4Dx is making a bold foray into the global respiratory diagnostics marketplace after strong support from the U.S, U.K and Australian investment community. Their AU$4M Series A investment round is set to close, oversubscribed, on December 9th after the inking of deals with major U.S hospitals and expanding relationships with key U.K medical institutions. 4Dx has developed unique software that generates moving, ultra-high-resolution images of motion and airflow in lung tissue. This revolutionary technology enables clinicians to view and measure abnormal lung function at the earliest stages of disease in a way that has not previously been possible. 4Dx technology is non-invasive and will have a major impact on the way medical professionals are able to diagnose and treat patients with diseases of the lung. 4Dx has also established formal clinical partnerships with several of the biggest and most advanced hospitals in the US, including Cedars-Sinai, The Cleveland Clinic, Children's Hospital Los Angeles, and the University of North Carolina at Chapel Hill. The company has also announced the appointment of Dr Bob Figlin to the 4Dx board from December 1st. Dr Figlin is Deputy Director of the Integrated Oncology Service Line, and Deputy Director at the Samuel Oschin Comprehensive Cancer Institute, part of the world-renowned Cedars-Sinai Medical Center in Los Angeles. He is also Director of the Hematology Oncology Division at the institute. Dr Figlin says, "4Dx has developed some of the most promising and exciting technology I've ever seen in the fight against disease. It will be a privilege to be able to use my medical and business experience to assist the company through this phase of its growth." Dr Figlin previously co-founded biotechnology company Agensys, which later sold as part of a nine-figure deal. 4Dx founder and chair Andreas Fouras, says, "Dr Figlin brings unparalleled experience and expertise in cancer therapies to 4Dx, where enhanced cancer treatment is among our first priorities. He also brings a vast medical knowledge and adds enormous capacity to our board's business decision making capacity." 4Dx is using investment monies to finance further clinical studies in addition to its first FDA submission, expected in Q1 2017. The AU$4M series A is open for investment in Australia and has also received strong interest from U.S and U.K markets, and will close on the 19th December. The company anticipates the raise will be over-subscribed. An additional round of fundraising is also planned for Q1 2017. About 4Dx: 4Dx is a software company aiming to deliver the global gold standard in respiratory diagnostics for all lung disorders, including, asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis and cancer. The unique 4Dx technology accurately and quickly scans lung function as the patient breathes, to provide sensitive, early diagnosis and to monitor changes over time. Our Software-as-a-Service scans deliver much more complete results, showing the subtlest variations in lung function down to the finest details, using lower levels of radiation than traditional methods. Respiratory diagnosis is a AU$40 billion p.a global industry that 4Dx aims to disrupt and grow through technology that provides clinicians with greater insights into diseases of the lung. 4Dx will bring about a step change in lung health by providing better information to doctors and patients. Better information means better decisions, and better outcomes.


News Article | November 30, 2016
Site: en.prnasia.com

LONDON, Nov. 30, 2016 /PRNewswire/ -- Robert A. Figlin, MD, FACP, joins the 4Dx board on December 1st.  Dr Figlin is Deputy Director of the Integrated Oncology Service Line. He also serves as the Deputy Director at the Samuel Oschin Comprehensive Cancer Institute, part of the world-renowned Cedars-Sinai Medical Center in Los Angeles and is Director of the Hematology Oncology Division at the institute, where he is in charge of integrating research and clinical strategies across all the Cedars-Sinai campuses. Since his arrival at Cedars- Sinai, he established the Experimental Therapeutics Program and successfully recruited clinical research staff in critical specialty areas such as breast cancer, bone marrow transplant, gastrointestinal oncology, genitourinary oncology, survivorship, and cancer biology. Dr Figlin says, "4Dx has developed some of the most promising and exciting technology I've ever seen in the fight against disease. It will be a privilege to be able to use my medical and business experience to assist the company through this phase of its growth." Dr Figlin co-founded Agensys - an early stage biotechnology company focussed on developing novel therapies for cancer.  The company has since been sold to Astellas Pharmaceuticals as part of a nine-figure deal. 4Dx founder and chair, Andreas Fouras, says, "Bob Figlin brings unparalleled experience and expertise in cancer therapies to 4Dx, where enhanced cancer treatment is among our first priorities. Bob brings a vast medical knowledge and adds enormous capacity to our board's business decision making capacity." Lung cancer is the biggest killer of all cancers and the current standard treatments of chemotherapy and radiotherapy have devastating effects on the lungs. 4Dx technology is non-invasive and will positively impact the way medical professionals are able to diagnose, and treat their patients. "4Dx is undergoing significant acceleration and is thrilled to have a clinician, researcher and entrepreneurial thinker in Bob Figlan join our team." "This revolutionary technology and the development of unique software to generate moving, ultra-high-resolution images of motion and airflow in lung tissue enables clinicians to view and measure abnormal lung function at the earliest stages of disease in a way that has not been possible before now." As well as their association with Cedars- Sinai, 4Dx has also created partnerships with other leading hospitals such as the Cleveland Clinic and the Children's Hospital Los Angeles in the US, and The Alfred and Peter Mac in Australia. About 4Dx: 4Dx is a software company aiming to deliver the global gold standard in respiratory diagnostics for all lung disorders, including, asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis and cancer. The unique 4Dx technology accurately and quickly scans lung function as the patient breathes, to provide sensitive, early diagnosis and to monitor changes over time. Our Software-as-a-Service scans deliver much more complete results, showing the subtlest variations in lung function down to the finest details, using lower levels of radiation than traditional methods. Respiratory diagnosis is a $25 billion p.a global industry that 4Dx aims to disrupt and grow through technology that provides clinicians with greater insights into diseases of the lung. 4Dx will bring about a step change in lung health by providing better information to doctors and patients.

Loading Oncology Service collaborators
Loading Oncology Service collaborators