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Ymittos Athens, Greece

Grasso R.F.,Interventional Imaging | Luppi G.,Interventional Imaging | Cazzato R.L.,Interventional Imaging | Faiella E.,Interventional Imaging | And 3 more authors.
Tumori | Year: 2012

Aims and background. "Augmented reality" is a technique to create a composite view by augmenting the real intervention field, visualized by the doctor, with additional information coming from a virtual volume generated using computed tomography (CT), magnetic resonance or ultrasound images previously acquired from the same patient. In the present study we verified the accuracy and validated the clinical use of an augmented reality navigation system produced to perform percutaneous CT-guided lung biopsies. Methods. One hundred and eighty consecutive patients with solitary parenchymal lung lesions, enrolled using a nonrandom enrollment system, underwent percutaneous CT-guided aspiration and core biopsy using a traditional technique (group C, 90 patients) and navigation system assistance (group S, 90 patients). For each patient we recorded the largest lesion diameter, procedure time, overall number of CT scans, radiation dose, and complications. The entire experimental project was evaluated and approved by the local institutional review board (ethics committee). Results. Each procedure was concluded successfully and a pathological diagnosis was reached in 96% of cases in group S and 90% of cases in group C. Procedure time, overall number of CT scans and incident x-ray radiation dose (CTDIvol) were significantly reduced in navigation system-assisted procedures (P <0.001; z = 5.64) compared with traditional CT-guided procedures. The percentage of procedural complications was 14% in group S and 17% in group C. Conclusion. The augmented reality navigation system used in this study was a highly safe, technically reliable and effective support tool in percutaneous CT-guided lung biopsy, allowing to shorten the procedure time and reduce the incident x-ray radiation dose to patients and the rate of insufficient specimens. Furthermore, it has the potential to increase the number of procedures executed in the allocated time without increasing the number of complications. © II Pensiero Scientifico Editore downloaded by EXCERPTA MEDICA.

Vasiadi M.,Tufts University | Vasiadi M.,National and Kapodistrian University of Athens | Therianou A.,National and Kapodistrian University of Athens | Alysandratos K.D.,Tufts University | And 10 more authors.
British Journal of Dermatology | Year: 2012

Background: Psoriasis involves skin inflammation that often worsens with stress, but the mechanism of this effect remains obscure. We have shown that corticotropin-releasing hormone (CRH) is increased in the serum of patients with psoriasis. A peptide, neurotensin (NT), can trigger skin histamine release and augment the ability of CRH to increase skin vascular permeability. Objectives: To investigate the serum level of NT, and the expression of genes for NT and NT receptor-1 (NTR-1) in lesional and nonlesional skin of patients with psoriasis, compared with normal controls. Also, to study the effect of NT on human mast cell release of vascular endothelial growth factor (VEGF), which is increased in psoriatic skin. Methods Serum was obtained from patients with psoriasis (n = 56) and controls (n = 33); NT levels were measured with the Milliplex microbead assay. Biopsies were obtained from the lesional and nonlesional skin of patients with chronic plaque psoriasis (n = 40), who had not received any treatment for at least 15 days and were free of any systemic inflammatory diseases. Control skin samples were obtained from healthy subjects (n = 30). Expression of genes for NT and NTR-1 in the skin was evaluated by quantitative reverse transcriptase-polymerase chain reaction. LAD2 human mast cells were stimulated by NT (1 μmol L -1) for 24 h and VEGF was measured by enzyme-linked immunosorbent assay. Results: Serum NT was increased in patients with psoriasis, while expression of genes for NT and NTR-1 in lesional skin was decreased compared with controls. NT induced VEGF release from mast cells and was augmented by interleukin-33. Conclusion: NT may play a role in psoriasis pathogenesis and its worsening by stress, at least in part through activation of skin mast cells. © 2012 British Association of Dermatologists.

Balci T.A.,Firat University | Koc Z.P.,Firat University | Demirel B.B.,Oncology Hospital
Journal of Clinical and Analytical Medicine | Year: 2012

Aim Diagnosis of the hepatic hemangiomas is sometimes difficult by means of computed tomography (CT) or ultrasound (USG). This kind of lesions can be accurately identified by Tc-99m labeled erythrocyte -red blood cell (RBC) imaging. However there are controversial results about small lesions (<1.5 cm). Aim of this study is to evaluate the effect of lesion size in the diagnosis of liver hemangioma by using Tc-99m labeled RBC scintigraphy. Material and Methods Forty-two patients who had liver lesions with the suspicion of hemangioma were retrospectively evaluated. Tc-99m RBC scintigraphy results of the patients were compared with 3-24 months clinical or USG follow-up or morphological imaging methods (dynamic computerized tomography or magnetic resonance imaging (MRI)). Results Twenty seven of 42 patients had follow-up and their diagnosis was confirmed. Sensitivity, specificity, accuracy, positive and negative predictive value of Tc- 99m RBC scintigraphy according to follow up results were 92%, 66%, 89%, 96% and 50%, respectively. Two false negative lesions were smaller than 1.5 cm (10 mm, 13 mm). One of the 3 patients with small lesion who came for follow-up had true positive result. Existence of small lesions in the study made the specificity and negative predictive value decreased. Conclusions Although small sized (<1.5 cm) hemangiomas sometimes can also be visualized with Tc-99m RBC scintigraphy, this technique is very sensitive especially for large lesions.

Kumtepe Y.,Ataturk University | Cetinkaya K.,Oncology Hospital
Research Journal of Medical Sciences | Year: 2012

Cancer caused by a mutated gene is a hereditary cancer rather than a sporadic cancer. Women who have inherited mutations in the BRCA1 or BRCA2 genes have substantially elevated risks of breast and ovarian cancer. Further genetic risk assessment is recommended for women who have >20-25% chance of having an inherited predisposition to breast or ovarian cancer. Women with harmful mutations in either BRCA1 or BRCA2 have risk of breast cancer that is about 5 times the normal risk and a risk of ovarian cancer that is about 10-30 times normal. Mutation carriers have various options including extensive and regular surveillance, chemoprevention and risk-reducing surgery. © Medwell Journals, 2012.

Aslan S.,Oncology Hospital
Bratislavské lekárske listy | Year: 2011

Wound infection, flap necrosis rates and peripheral complete blood cell count changes related to intraoperative whole-blood transfusions were investigated. Evidence is growing that whole-blood cell transfusions are immunosuppressive and predispose patients to postoperative infections. 102 female breast carcinoma patients with hemoglobin levels = 10 g/dl before modified radical mastectomy and < 10 g/dl intraoperatively but with no signs of oxygen debt were included. Group I included patients who had received two units of whole-blood transfusions intraoperatively. Patients who had received no transfusion were in group II. Peripheral complete blood cell count, wound infection rates and flap necrosis were compared. Perioperative neutrophile and monocyte count increased in both groups. This increase was especially significant in the transfused group (p < 0.05). In both groups, these changes returned to normal levels on the tenth postoperative day. The decreased perioperative basophile count did not return to the baseline even on the tenth postoperative day in group I (p < 0.05). Lymphocyte count, and flap necrosis did not differ between the groups (p > 0.05). Wound infection seemed to take place and increase in the transfused group (p < 0.05). Two units of whole-blood transfusions seem to increase wound infection and decrease basophile count in this series (Tab. 3, Ref. 30).

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