Oncologia Pediatrica

Catania, Italy

Oncologia Pediatrica

Catania, Italy
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Farruggia P.,Pediatric Hematology and Oncology Unit | Puccio G.,University of Palermo | Sala A.,University of Milan Bicocca | Todesco A.,University of Padua | And 15 more authors.
European Journal of Cancer | Year: 2016

Background Many biological and inflammatory markers have been proposed as having a prognostic value at diagnosis of Hodgkin lymphoma (HL), but very few have been validated in paediatric patients. We explored the significance of these markers in a large population of 769 affected children. Patients and methods By using the database of patients enrolled in A.I.E.O.P. (Associazione Italiana di Emato-Oncologia Pediatrica) trial LH2004 for paediatric HL, we identified 769 consecutive patients treated with curative intent from 1st June 2004 to 1st April 2014 with ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), or hybrid COPP/ABV (cyclophosphamide, vincristine, prednisone, procarbazine, doxorubicin, bleomycin and vinblastine) regimens. Results On multivariate analysis with categorical forms, the 5-year freedom from progression survival was significantly lower in patients with stage IV or elevated value of platelets, eosinophils and ferritin at diagnosis. Furthermore, stage IV and eosinophils seem to maintain their predictive value independently of interim (after IV cycles of chemotherapy) positron emission tomography. Conclusion Using the combination of four simple markers such as stage IV and elevated levels of platelets, ferritin and eosinophils, it is possible to classify the patients into subgroups with very different outcomes. © 2015 Elsevier Ltd.


Fagioli F.,Oncoematologia Pediatrica e Centro Trapianti | Zecca M.,Oncoematologia Pediatrica | Rognoni C.,University of Pavia | Lanino E.,Instituto G Gaslini | And 9 more authors.
Biology of Blood and Marrow Transplantation | Year: 2012

Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL) still represents a major challenge. We report the experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP) with allogeneic hematopoietic stem cell transplantation (HSCT) in children with Ph+ ALL from 1990 to 2008. Sixty-nine patients received HSCT from either a related (37, 54%) or an unrelated (32, 46%) donor. Twenty-five patients (36%) underwent transplantation before 2000 and 44 (64%) after 2000. Twenty-three patients (33%) received Imatinib mesylate treatment before HSCT and seven (10%) after HSCT. After a median follow-up of 56 months, the overall survival (OS) probability was 51% (95% confidence interval [CI], 38-63), the leukemia-free survival (LFS) was 47% (95% CI, 34-59), transplantation-related mortality (TRM) was 17% (95% CI, 10-30), and relapse incidence (RI) was 36% (95% CI, 26-50). Transplantation in first complete remission, female gender, and lower WBC count at diagnosis were associated with a better LFS in both univariate and multivariate analyses. Patients with p210 transcript had a trend for a worse prognosis compared with those who had the p190 transcript. Our series confirms the role of HSCT in the eradication of Ph+ ALL. Early HSCT is recommended once morphologic remission is obtained. © 2012 American Society for Blood and Marrow Transplantation.


Murata C.,Subdireccion de Investigacion Medica | Ysusi-Mendoza F.,Oncologia Pediatrica | Leal-Leal C.,Clinica de Retinoblastoma
Acta Pediatrica de Mexico | Year: 2015

Purpose: We investigated the prevalence of low weight and height in a population of Mexican children afflicted with retinoblastoma; we correlate these anthropometric measurements with characteristics of the disease and variables in the environment. Methods: There were 346 patients with a histopathological diagnosis of retinoblastoma reported by the Oncology Service of the Instituto Nacional de Padiátría (INP). Weight and height were recorded in the patient charts prior to treatment. The Z-score was used to compare the study for mean somatometric value distribution with that of the data from the National Center for Health Statistics [NCHS]/Center for Disease Control and Prevention [CDC] and reference for Mexican population. The association of the variables related to the clinical, social and genetic aspects of retinoblastoma with the low weight and short height was assessed by the ratio chi square test. Results: The average weight and the average height of the retinoblastoma population were significantly lower than those of the general population (p<0.001 and p=0.013, respectively). Low weight and Short stature in retinoblastoma patients was more frequent among those with advanced disease, rural environment and lower socioeconomic levels. Conclusions: The weight and height deficit present in a large proportion of children with retinoblastoma is due to factors such as an advanced stage of the condition at diagnosis, which, in turn, is symptomatic in the rural populations of the poorest areas of Mexico. Given that most social and environmental variables are highly interrelated, and the occurrence of possible genetic factors throughout Mexico cannot be discarded, the conclusions of the present study should be verified by analyzing the somatometric measurements of the parents and relatives of the patients, in order to establish comparison group comparison to and to assent these confounding variables. © 2014 Acta Pediátr Mex.


Farruggia P.,Pediatric Hematology and Oncology Unit | Puccio G.,University of Palermo | Sala A.,University of Milan Bicocca | Todesco A.,University of Padua | And 14 more authors.
Cancer Medicine | Year: 2016

The purpose of the study was to determine if abdomen/pelvis computed tomography (CT) can be safety omitted in the initial staging of a subgroup of children affected by Hodgkin Lymphoma (HL). Every participating center of A.I.E.O.P (Associazione Italiana di Ematologia ed Oncologia Pediatrica) sent local staging reports of 18F-fluorodeoxyglucose positron emission tomography (PET) and abdominal ultrasound (US) along with digital images of staging abdomen/pelvis CT to the investigation center where the CT scans were evaluated by an experienced pediatric radiologist. The local radiologist who performed the US was unaware of local CT and PET reports (both carried out after US), and the reviewer radiologist examining the CT images was unaware of local US, PET and CT reports. A new abdominal staging of 123 patients performed on the basis of local US report, local PET report, and centralized CT report was then compared to a simpler staging based on local US and PET. No additional lesion was discovered by CT in patients with abdomen/pelvis negativity in both US and PET or isolated spleen positivity in US (or US and PET), and so it seems that in the initial staging, abdomen/pelvis CT can be safety omitted in about 1/2 to 2/3 of children diagnosed with HL. © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.


PubMed | University of Padua, Oncologia Pediatrica, Catanzaro Hospital, Pediatric Hematology Oncology and 8 more.
Type: Journal Article | Journal: Cancer medicine | Year: 2016

The purpose of the study was to determine if abdomen/pelvis computed tomography (CT) can be safety omitted in the initial staging of a subgroup of children affected by Hodgkin Lymphoma (HL). Every participating center of A.I.E.O.P (Associazione Italiana di Ematologia ed Oncologia Pediatrica) sent local staging reports of 18F-fluorodeoxyglucose positron emission tomography (PET) and abdominal ultrasound (US) along with digital images of staging abdomen/pelvis CT to the investigation center where the CT scans were evaluated by an experienced pediatric radiologist. The local radiologist who performed the US was unaware of local CT and PET reports (both carried out after US), and the reviewer radiologist examining the CT images was unaware of local US, PET and CT reports. A new abdominal staging of 123 patients performed on the basis of local US report, local PET report, and centralized CT report was then compared to a simpler staging based on local US and PET. No additional lesion was discovered by CT in patients with abdomen/pelvis negativity in both US and PET or isolated spleen positivity in US (or US and PET), and so it seems that in the initial staging, abdomen/pelvis CT can be safety omitted in about 1/2 to 2/3 of children diagnosed with HL.


PubMed | University of Padua, U.O. Oncoematologia Pediatrica, University of Pavia, Centro Of Riferimento Oncologico Aviano and 12 more.
Type: | Journal: European journal of cancer (Oxford, England : 1990) | Year: 2016

Many biological and inflammatory markers have been proposed as having a prognostic value at diagnosis of Hodgkin lymphoma (HL), but very few have been validated in paediatric patients. We explored the significance of these markers in a large population of 769 affected children.By using the database of patients enrolled in A.I.E.O.P. (Associazione Italiana di Emato-Oncologia Pediatrica) trial LH2004 for paediatric HL, we identified 769 consecutive patients treated with curative intent from 1st June 2004 to 1st April 2014 with ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), or hybrid COPP/ABV (cyclophosphamide, vincristine, prednisone, procarbazine, doxorubicin, bleomycin and vinblastine) regimens.On multivariate analysis with categorical forms, the 5-year freedom from progression survival was significantly lower in patients with stage IV or elevated value of platelets, eosinophils and ferritin at diagnosis. Furthermore, stage IV and eosinophils seem to maintain their predictive value independently of interim (after IV cycles of chemotherapy) positron emission tomography.Using the combination of four simple markers such as stage IV and elevated levels of platelets, ferritin and eosinophils, it is possible to classify the patients into subgroups with very different outcomes.

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