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Padova, Italy

Zustovich F.,Oncologia Medical | Farina P.,Oncologia Medical | Amirouchene N.,Oncologia Medical | Carli P.,Oncologia Medical | And 3 more authors.
Cancer Therapy | Year: 2010

Aims and Background: there is no evidence of benefit for adjuvant chemotherapy in high-risk patients with urothelial carcinomas; to improve results of surgery we treated a series of patients with a multi-drug sequential chemotherapy protocol. Methods: patients with G3 or pT3 or pN+ urinary tract carcinomas were treated with 3 courses of carboplatin plus gemcitabine every 21 days followed by 3 courses of paclitaxel, vinorelbine and methotrexate every 21 days. Results: 21 patients were enrolled, all patients were evaluable for toxicity that was manageable and mostly haematological grade 1-2, 9 patients needed some dose reduction. The median disease-free survival (DFS) was of 21.8 months (4.3-48.7+) and median overall survival (OS) was of 25.4 months (9-51.4). Conclusions: carboplatin and gemcitabine followed by paclitaxel, vinorelbine and methotrexate is feasible and safe and might deserve to be studied in a fase III trial of adjuvant chemotherapy for patients with high-risk urothelial carcinomas.

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