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Mansour H.,University of Teesside | Mansour H.,Omer Al Mukhtar University | Ahmad M.,University of Teesside | Ahtita F.,Gulf
FAIM 2014 - Proceedings of the 24th International Conference on Flexible Automation and Intelligent Manufacturing: Capturing Competitive Advantage via Advanced Manufacturing and Enterprise Transformation | Year: 2014

In this work Practical Evaluation Workover Framework (PEWF) can be defined as a procedure that provides a practical workover maintenance system for workover and production engineers in the Oilfields. This procedure involves operators and technicians in the workover rigs acting as a team to monitor the workover procedures including Electrical Submersible Pump (ESP) processes (installation and nu-installation) and reduce the production losses in the oil wells by returning the oil well to production in the right time. The model's detail and procedures are simple to use and it supports workover rigs to implement the main structures of Total productive maintenance (TPM) to improve the efficiency of the workover rig. PEWF is built on the collection and analysis of the Overall equipment effectiveness (OEE) data gathered by the workover and production engineers on the workover rig. The OEE monitors the actual performance of workover relative to its performance capabilities under optimal workover conditions. The main purpose of an OEE results is to present essential data against where decisions may be made. These measurements assist the management to evaluate progress and help production and workover engineers identify the sources of problems on ESP processes and workover rigs activities. This method of calculating rig efficiency provides the practical measure of the workover performance which can aid in rig procedures negotiation and workover rig selection. © Copyright 2014 by DEStech Publications, Inc. All rights reserved. Source

Surampalli G.,Vaagdevi Institute of Pharmaceutical science | Nanjwade B.K.,KLE University | Patil P.A.,Omer Al Mukhtar University
Journal of Pharmacy and Pharmacology | Year: 2015

Objective In this study, a comprehensive and comparative cytotoxic evaluation of morin against verapamil on rat intestinal epithelium as P-gp inhibitors through in-vitro gastrointestinal short-term toxicity assays involving permeability studies for safety evaluation was investigated. Methods In this study, the effect of morin (1 mM or 10 mM) or verapamil (1 mM or 10 mM) or sodium deoxycholate (10 mM) was investigated on intestinal epithelium and isolated brush border membrane using biomarker assays. Cytotoxicity was determined using 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) assay. The nutrients transport was assessed using everted sacs studies. Paracellular permeability was measured using Lucifer yellow, followed by morphometric analysis of intestinal sacs. Key findings Our results indicated that morin was effective in maintaining cell viability with no significant changes (P > 0.05) in the activity of intestinal brush border markers, membrane integrity and morphometric analysis as compared with control. On the contrary, dramatic (P < 0.01) changes were noticed in the release of membrane markers, cell viability and surface characteristics of intestinal segments when treated with verapamil or sodium deoxycholate as compared with control or morin. Conclusions Our findings confirm that morin is non-toxic to rat intestinal epithelium against verapamil demonstrating the potential use of bioflavonoid as safe and novel pharmaceutical adjuvant as P-gp inhibitor. © 2015 Royal Pharmaceutical Society. Source

Dange S.M.,P.A. College | Kamble M.S.,P.A. College | Bhalerao K.K.,P.A. College | Chaudhari P.D.,P.A. College | And 3 more authors.
Journal of Bionanoscience | Year: 2014

Venlafaxine is newer class of antidepressant used in treatment of depression. In the presents study, we aimed to prepare a nanostructured lipid carrier (NLC) gel, for the intranasal drug delivery of Venlafaxine. The Venlafaxine loaded NLCs were prepared by emulsion solvent diffusion and evaporation method followed by ultrasonication. Properties of nanostructured lipid carriers such as particle size and its distribution, % Drug loading were investigated. The NLC dispersion was suitably gelled and characterized for drug content, pH, viscosity, in-vitro and ex-vivo release and in-vivo pharmacodynamic study. FTIR and DSC analyses showed no significant chemical interaction between Venlafaxine and excipients in the formulation. The particle size of optimized batch of NLCs was found to be 151.83 nm and zeta potential was found to be ?8.08 mV. Drug loading was found to be 34.33±2.180%. A toxicological study carried out on sheep nasal mucosa showed no evidence of toxicity of the NLC based gel. The NLC based gel showed a rapid onset alongwith a prolonged duration of action as compared with pure drug solution and NLC dispersion. Copyright © 2014 American Scientific Publishers All rights reserved. Source

Algani Z.A.,National University of Malaysia | Omar N.,Omer Al Mukhtar University
Journal of Computer Science | Year: 2012

Problem statement: Scientific translation represents an important stream in the current century due to explosion of the information revolution. The translation of scientific text is still limited in accuracy due to the fact that the scientific terms cannot be translated appropriately. Word order rules are very important for the generation of sentences in the target language whereas the word order in Arabic language is different from the order in English. Any Arabic Machine Translation (MT) system to English should be able to deal with word order. Approach: The aim of this study is to introduces-MT (Verbal Sentence rule based Machine Translation), an automatic system for Arabic verbal sentence of scientific text to English translation using transfer based approach. Verbal sentences constitute the majority of Arabic scientific document. The system involves three phases: analysis, transfer and generation phase. The transfer method is one of the rule based approach category and the most common technique used in machine translation system. Results: The system was trained on 45 verbal sentences from different Arabic scientific text and tested on 30 new verbal sentences from different domain. An experiment performed involves comparison with two other machine translation systems namely Syzran and Google. The accuracy of the result of the designed system is 93%. Conclusion: VS-MT has been successfully implemented and tested on many verbal sentences from different field of Arabic thesis. An experiment was performed which involves comparison with two other machine translation systems namely Syzran and Google. Our approach is efficient enough to translate Arabic verbal sentences of scientific text to English. © 2012 Science Publications. Source

Surampalli G.,Vaagdevi Institute of Pharma science | Nanjwade B.K.,Omer Al Mukhtar University | Patil P.A.,KLE University
Drug Development and Industrial Pharmacy | Year: 2015

Objective: The aim of this study was to corroborate the effects of naringin, a P-glycoprotein inhibitor, on the intestinal absorption and pharmacokinetics of candesartan (CDS) from candesartan cilexetil (CAN) solid dispersions using in-situ rat models. Materials and methods: Intestinal transport and absorption studies were examined by in-situ single pass perfusion and closed-loop models. We evaluated the intestinal membrane damage in the presence of naringin by measuring the release of protein and alkaline phosphatase (ALP). Results and discussion: We noticed 1.47-fold increase in Peff of CDS from freeze-dried CAN-loaded solid dispersions with naringin (15mg/kg, w/w) when compared with freeze-dried solid dispersion without naringin using in-situ single pass intestinal perfusion model. However, no intestinal membrane damage was observed in the presence of naringin. Our findings from in-situ closed-loop pharmacokinetic studies showed 1.34-fold increase in AUC with elevated Cmax and shortened tmax for freeze-dried solid dispersion with naringin as compared to freeze-dried solid dispersion without naringin. Conclusion: This study demonstrated that increased solubilization (favored by freeze-dried solid dispersion) and efflux pump inhibition (using naringin), the relative bioavailability of CDS can be increased, suggesting an alternative potential for improving oral bioavailability of CAN. © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted. Source

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