Omer Al Mukhtar University

Tobruk, Libya

Omer Al Mukhtar University

Tobruk, Libya
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Madhuri D.,JNTUniversity | Chandrasekhar K.B.,JNTUniversity | Devanna N.,JNTUniversity | Somasekhar G.,Omer Al Mukhtar University
Rasayan Journal of Chemistry | Year: 2010

A simple, sensitive and accurate spectrophotometric method was described for the determination of Gemifloxacin mesylate (GFX) a broad spectrum flouroquinolone anti bacterial either in pure form or in the tablet.The method is based on chelate formation between GFX and Chromium(Cr III) in aqueous media. The complex showed an absorption maximum at 545nm for zero order,Ist derivative at 620nm and Second derivative at 660nm respectively with apparent molar absorpitivities of 1.07×104 L-M-1Cm-1,,7.01×103 L-M-1 Cm-1 for Ist order derivative, 1.04×104 LM-1Cm-1 for 2nd order derivative respectively. The solution of the complex obeyed beer's law in the concentration range of 2 to 20μg/ml for zero order,1 to 15 μg/ml for Ist order and 1 to 25 μg/ml for 2nd order respectively. The limit of detection and Limit of quantification were calculated and RSD were less than 0.2866. The chelate composition between GFX and Cr(III) ion was found to be 1:1 ratio determined by Job's continuous method and by Molar ratio method. The proposed method was applied for the determination of GFX in tablets without interference from common excipients. The results obtained by the application of this procedure showed percentage recoveries were 99.9±0.1463 for zero order, 100.2±0.1065 for Ist order and 100.6±0.1589 for 2nd order respectively.


Madhuri D.,Jntuniversity | Chandrasekhar K.B.,Jntuniversity | Devanna N.,Jntuniversity | Somasekhar G.,Omer Al Mukhtar University
Rasayan Journal of Chemistry | Year: 2010

A simple,sensitive and accurate spectrophotometric method was described for the determination of Gemifloxacin mesylate (GFX) a broad spectrum flouroquinolone anti bacterial either in pure form or in the tablet.The method is based on chelate formation between GFX and Palladium (Pd II) in aqueous media. The complex showed an absorption maximum at 430nm,Ist derivative at 480nm and Second derivative at 500nm respectively with apparent molar absorpitivities of 1.365x104 L-M-1Cm-1, 9.37x104 L-M-1Cm-1 for Ist order derivative, 1.59X10LM-1Cm-1 for 2nd order derivative respectively. The solution of the complex obeyed beer's law in the concentration range of 2to 14 μg/ml for zero order,1 to 10 μg/ml for Ist order and 1to 15 μg/ml for 2nd order respectively. The limit of detection and Limit of quantification were calculated and RSD were less than 0.153. The chelate composition between GFX and Pd(II) ion was found to be 1:1 ratio determined by Job's continuous method and by Molar ratio method. The proposed method was applied for the determination of GFX in tablets without interference from common excipients. The results obtained by the application of this procedure showed percentage recoveries were 99.8±0.153 for zero order, 100.02±0.177 for Ist order and 100.045±0.139 for 2nd order respectively.


Algani Z.A.,National University of Malaysia | Omar N.,Omer Al Mukhtar University
Journal of Computer Science | Year: 2012

Problem statement: Scientific translation represents an important stream in the current century due to explosion of the information revolution. The translation of scientific text is still limited in accuracy due to the fact that the scientific terms cannot be translated appropriately. Word order rules are very important for the generation of sentences in the target language whereas the word order in Arabic language is different from the order in English. Any Arabic Machine Translation (MT) system to English should be able to deal with word order. Approach: The aim of this study is to introduces-MT (Verbal Sentence rule based Machine Translation), an automatic system for Arabic verbal sentence of scientific text to English translation using transfer based approach. Verbal sentences constitute the majority of Arabic scientific document. The system involves three phases: analysis, transfer and generation phase. The transfer method is one of the rule based approach category and the most common technique used in machine translation system. Results: The system was trained on 45 verbal sentences from different Arabic scientific text and tested on 30 new verbal sentences from different domain. An experiment performed involves comparison with two other machine translation systems namely Syzran and Google. The accuracy of the result of the designed system is 93%. Conclusion: VS-MT has been successfully implemented and tested on many verbal sentences from different field of Arabic thesis. An experiment was performed which involves comparison with two other machine translation systems namely Syzran and Google. Our approach is efficient enough to translate Arabic verbal sentences of scientific text to English. © 2012 Science Publications.


Mohammed M.A.,National University of Malaysia | Omar N.,National University of Malaysia | Omar N.,Omer Al Mukhtar University
Journal of Computer Science | Year: 2011

Problem statement: One of language processing approaches that compute a basic analysis of sentence structure rather than attempting full syntactic analysis is shallow syntactic parsing. It is an analysis of a sentence which identifies the constituents (noun groups, verb groups, prepositional groups), but does not specify their internal structure, nor their role in the main sentence. The only technique used for Arabic shallow parser is Support Vector Machine (SVM) based approach. The problem faced by shallow parser developers is the boundary identification which is applied to ensure the generation of high accuracy system performance. Approach: The specific objective of the research was to identify the entire Noun Phrases (NPs), Verb Phrases (VPs) and Prepositional Phrases (PPs) boundaries in the Arabic language. This study discussed various idiosyncrasies of Arabic sentences to derive more accurate rules to detect start and the end boundaries of each clause in an Arabic sentence. New rules were proposed to the shallow parser features up to the generation of two levels from full parse-tree. We described an implementation and evaluate the rule-based shallow parser that handles chunking of Arabic sentences. This research was based on a critical analysis of the Arabic sentences architecture. It discussed various idiosyncrasies of Arabic sentences to derive more accurate rules to detect the start and the end boundaries of each clause in an Arabic sentence. Results: The system was tested manually on 70 Arabic sentences which composed of 1776 words, with the length of the sentences between 4-50 words. The result obtained was significantly better than state of the art Arabic published results, which achieved F-scores of 97%. Conclusion: The main achievement includes the development of Arabic shallow parser based on rule-based approaches. Chunking which constitutes the main contribution is achieved on two successive stages that include grouped sequences of adjacent words on the basis of linguistic properties. © 2011 Science Publications.


Surampalli G.,Vaagdevi Institute of Pharmaceutical science | Nanjwade B.K.,KLE University | Patil P.A.,Omer Al Mukhtar University
Journal of Pharmacy and Pharmacology | Year: 2015

Objective In this study, a comprehensive and comparative cytotoxic evaluation of morin against verapamil on rat intestinal epithelium as P-gp inhibitors through in-vitro gastrointestinal short-term toxicity assays involving permeability studies for safety evaluation was investigated. Methods In this study, the effect of morin (1 mM or 10 mM) or verapamil (1 mM or 10 mM) or sodium deoxycholate (10 mM) was investigated on intestinal epithelium and isolated brush border membrane using biomarker assays. Cytotoxicity was determined using 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) assay. The nutrients transport was assessed using everted sacs studies. Paracellular permeability was measured using Lucifer yellow, followed by morphometric analysis of intestinal sacs. Key findings Our results indicated that morin was effective in maintaining cell viability with no significant changes (P > 0.05) in the activity of intestinal brush border markers, membrane integrity and morphometric analysis as compared with control. On the contrary, dramatic (P < 0.01) changes were noticed in the release of membrane markers, cell viability and surface characteristics of intestinal segments when treated with verapamil or sodium deoxycholate as compared with control or morin. Conclusions Our findings confirm that morin is non-toxic to rat intestinal epithelium against verapamil demonstrating the potential use of bioflavonoid as safe and novel pharmaceutical adjuvant as P-gp inhibitor. © 2015 Royal Pharmaceutical Society.


Surampalli G.,Vaagdevi Institute of Pharma science | Nanjwade B.K.,Omer Al Mukhtar University | Patil P.A.,KLE University
Drug Development and Industrial Pharmacy | Year: 2015

Objective: The aim of this study was to corroborate the effects of naringin, a P-glycoprotein inhibitor, on the intestinal absorption and pharmacokinetics of candesartan (CDS) from candesartan cilexetil (CAN) solid dispersions using in-situ rat models. Materials and methods: Intestinal transport and absorption studies were examined by in-situ single pass perfusion and closed-loop models. We evaluated the intestinal membrane damage in the presence of naringin by measuring the release of protein and alkaline phosphatase (ALP). Results and discussion: We noticed 1.47-fold increase in Peff of CDS from freeze-dried CAN-loaded solid dispersions with naringin (15mg/kg, w/w) when compared with freeze-dried solid dispersion without naringin using in-situ single pass intestinal perfusion model. However, no intestinal membrane damage was observed in the presence of naringin. Our findings from in-situ closed-loop pharmacokinetic studies showed 1.34-fold increase in AUC with elevated Cmax and shortened tmax for freeze-dried solid dispersion with naringin as compared to freeze-dried solid dispersion without naringin. Conclusion: This study demonstrated that increased solubilization (favored by freeze-dried solid dispersion) and efflux pump inhibition (using naringin), the relative bioavailability of CDS can be increased, suggesting an alternative potential for improving oral bioavailability of CAN. © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted.


Mohammed A.A.,Omer Al Mukhtar University
Jordan Medical Journal | Year: 2015

Objective: To highlight our management of idiopathic spontaneous intestinal perforation (ISIP) in two medical teaching hospitals. Methods: Retrospective study was done between Sept. 2003-Sept 2011. Results: The total number of patients was 9. The gestational age ranged between 27-29 weeks. The age at presentation ranged between 8-21 days. All the patients were males. Clinically there was severe tympanic abdominal distention. Radiologically there was severe pneumoperitonium. Operatively there was single perforation with normal surrounding bowel. The treatment was primary explorative laparotomy in 4/9 patients and primary peritoneal (PPD) drainage in 5/9 patients. The total survival rate was 77.7%. The total morbidity rate was 25%. The morbidity and mortality rate after PPD were zero. Conclusions: ISIP is a serious condition associated with a high mortality rate if not promptly recognized and treated. To overcome the high mortality, PPD is a good option to rescue and stabilize the patient before the definitive treatment. © 2015 DAR Publishers/The University of Jordan. All Rights Reserved.


PubMed | KLE University, Vaagdevi Institute of Pharmaceutical science and Omer Al Mukhtar University
Type: Comparative Study | Journal: Drug delivery | Year: 2016

To assess the effect of naringenin on the intestinal biochemical composition, function and histology for gastrointestinal toxicity since it has not yet been adequately exploited for safety through standard assays.Here, we describe naringenin (1mM, 10mM and 100mM, respectively) or sodium deoxycholate (10mM) effects on isolated brush border membrane from intestinal segments with single pass intestinal perfusion using lactate dehydrogenase, alkaline phosphatase and protein assays. MTT assay was used for cytotoxicity studies. Everted gut sac studies were used for evaluating the transport of nutrients across the intestinal segments. Lucifer yellow was used for paracellular permeability, followed by histological changes and surface characteristic studies of intestinal sacs.The results indicated no significant alterations with naringenin, although significant (p<0.01) changes were noticed with sodium deoxycholate in the activity of the rat intestinal brush border associated enzymes such as LDH, followed by intact cell viability with marked decrease in the villi height of the intestinal segments.These observations indicate that naringenin was harmless upon exposure to rat gastrointestinal epithelium, clearly demonstrating the potential use of naturally occurring bioflavonoid as safe and novel pharmaceutical adjuvant in oral dosage forms as P-gp inhibitor.


PubMed | KLE University, Vaagdevi Institute of Pharma science and Omer Al Mukhtar University
Type: Journal Article | Journal: Drug delivery | Year: 2015

The aim of this study was to develop a novel tablet formulation of amorphous candesartan cilexetil (CAN) solid dispersion involving effective P-gp inhibition for optimal drug delivery by direct compression (DC) method.To accomplish DC, formulation blends were evaluated for micromeritic properties. The Carr index, Hausner ratio, flow rate and cotangent of the angle were determined. The tablets with and without naringin prepared by DC technique were evaluated for average weight, hardness, disintegration time and friability assessments. The drug release profiles were determined to study the dissolution kinetics. In vivo pharmacokinetic studies were conducted in rabbits. Accelerated stability studies were performed for tablets at 402C/75% RH5% for 6 months.FTIR studies confirmed no discoloration, liquefaction and physical interaction between naringin and drug. The results indicated that tablets prepared from naringin presented a dramatic release (82%) in 30min with a similarity factor (76.18), which is most likely due to the amorphous nature of drug and the higher micromeritic properties of blends. Our findings noticed 1.7-fold increase in oral bioavailability of tablet prepared from naringin with mean CThese results are attractive for further development of an oral tablet formulation of CAN through P-gp inhibition using naringin, a natural flavonoid as a pharmaceutical excipient.


PubMed | KLE University, Vaagdevi Institute of Pharmaceutical science and Omer Al Mukhtar University
Type: Journal Article | Journal: The Journal of pharmacy and pharmacology | Year: 2015

In this study, a comprehensive and comparative cytotoxic evaluation of morin against verapamil on rat intestinal epithelium as P-gp inhibitors through in-vitro gastrointestinal short-term toxicity assays involving permeability studies for safety evaluation was investigated.In this study, the effect of morin (1mM or 10mM) or verapamil (1mM or 10mM) or sodium deoxycholate (10mM) was investigated on intestinal epithelium and isolated brush border membrane using biomarker assays. Cytotoxicity was determined using 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) assay. The nutrients transport was assessed using everted sacs studies. Paracellular permeability was measured using Lucifer yellow, followed by morphometric analysis of intestinal sacs.Our results indicated that morin was effective in maintaining cell viability with no significant changes (P>0.05) in the activity of intestinal brush border markers, membrane integrity and morphometric analysis as compared with control. On the contrary, dramatic (P<0.01) changes were noticed in the release of membrane markers, cell viability and surface characteristics of intestinal segments when treated with verapamil or sodium deoxycholate as compared with control or morin.Our findings confirm that morin is non-toxic to rat intestinal epithelium against verapamil demonstrating the potential use of bioflavonoid as safe and novel pharmaceutical adjuvant as P-gp inhibitor.

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