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Tehrān, Iran

Mohammadmoradi S.,Omega Research Team ORT | Javidan A.,Omega Research Team ORT | Kordi J.,Islamic Azad University at Tehran
Journal of Functional Foods | Year: 2014

As one of the major hepatic complications, non-alcoholic fatty liver disease (NAFLD) seems to be influenced by gut microbiota. Evidence suggests that alteration of intestinal microbiota plays a crucial role in the health of the gut-liver axis. Furthermore, bacterial translocation and altered intestinal permeability are also among the factors leading to the pathogenesis of liver disease. Recent studies have proposed that probiotics may have beneficial effects on the treatment/prevention of NAFLD and other hepatic complications due to their ability to augment intestinal barrier function, prevent production of lipopolysaccharides (LPS) and modulate the immune system. This study reviews and summarizes the available data regarding the relationship between gut microbiota and hepatic complications, focusing on the potential of probiotics as a new method of treatment/prevention for NAFLD. © 2014 Elsevier Ltd. Source


Mohammad Moradi S.,Omega Research Team ORT | Javidan A.,Omega Research Team ORT | Naji Isfahani H.,Omega Research Team ORT
Mediterranean Journal of Nutrition and Metabolism | Year: 2013

The role of probiotics and prebiotics as cholesterol reductive agents has drawn a great deal of attention. However, there have been few studies, investigating the effect of prebiotics and probiotics together on lipid profile. The purpose of study was to evaluate the effect of probiotic cheese (PCh) and chicory root extract consumption on lipid profile in a large sample. 180 subjects aged 18-65, with <6 mmol/l total cholesterol participated in the 7-week trial. Subjects randomly assigned into three 60-person groups. E1 consumed 30 g of PCh plus chicory root extract (daily), E2 consumed 30 g of PCh (daily) along with a control group. Probiotics strains in products were Lactobacillus acidophilus LA5 and Bifidobacterium lactis BB12. Anthropometric measurements and blood sampling were conducted at the baseline and end of trial. There was a significant reduction within both intervention groups throughout the study: intervention 1, (LDL: -0.79, 95 % CI -0.96, -0.61, P < 0.0001; cholesterol: -1.02, 95 % CI -1.41, -0.63, P < 0.0001; triglyceride: -0.59, 95 % CI -0.67, -0.51, P < 0.0001; HDL: 0.44, 95 % CI, 0.37, 0.51, P < 0.0001); intervention 2 also showed significant improvements in the mentioned factors. Comparing results of both groups with control showed significant improvements in all factors except triglyceride of intervention 2. PCh and chicory extract showed great effects on improvements of lipid profile, thus they can be used for prevention and treatment purposes. © 2013 Springer-Verlag Italia. Source

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