BRATTLEBORO, VT, United States
BRATTLEBORO, VT, United States
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Cote W.,Omega Optical Inc. | Slocum M.,Omega Optical Inc. | Chandra S.,Omega Optical Inc. | Fredell M.,Omega Optical Inc. | Rahmlow T.,Omega Optical Inc.
Optics InfoBase Conference Papers | Year: 2016

Single films were deposited for three oxides using electron beam and magnetron sputtering with no ion assist, low energy and high energy plasma assisted deposition processes. Refractive index, SEM and temperature stability data are presented for each film. © OSA 2016.

Johnson R.L.,Omega Optical Inc.
Optics InfoBase Conference Papers | Year: 2016

Narrow and ultra-narrowband optical filters provide high signal to noise selection in laser sensors, LIDAR imaging and free space communications. Design and manufacturing challenges for multi-cavity filters from the UV through infrared are discussed. © OSA 2016.

Barrett I.,Omega Optical Inc. | Herron J.,Omega Optical Inc. | Rahmlow T.,Omega Optical Inc. | L.Johnson R.,Omega Optical Inc.
Optics InfoBase Conference Papers | Year: 2016

Cryolite is a low index fluoride typically used in visible laminated coatings but is now seeing new applications in the infrared. Optical constants, temperature influence and example narrowband filters and sensors are presented. © OSA 2016.

Carver G.E.,Omega Optical Inc. | Locknar S.A.,Omega Optical Inc. | Morrison W.A.,Omega Optical Inc. | Farkas D.L.,Spectral Molecular Imaging, Inc.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2013

A new approach for generating high-speed multispectral images has been developed. The central concept is that spectra can be acquired for each pixel in a confocal spatial scan by using a fast spectrometer based on optical fiber delay lines. This concept merges fast spectroscopy with standard spatial scanning to create datacubes in real time. The spectrometer is based on a serial array of reflecting spectral elements, delay lines between these elements, and a single element detector. The spatial, spectral, and temporal resolution of the instrument is described, and illustrated by multispectral images of laser-induced autofluorescence in biological tissues. © 2013 Copyright SPIE.

Rahmlow T.D.,Omega Optical Inc. | Gallagher K.,Omega Optical Inc. | Johnson R.L.,Omega Optical Inc.
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2016

A method for fabricating filters for fiber optic sensors is presented. The interference filter's construction is laid on it's side to allow for the use of air as the low refractive index material. Bandpass filters tuned to the absorption line of a trace gas can then be used as a sensitive means of detecting gas concentration. Complex filter designs can be fabricated in a single patterned layer. A CO2/CH4 gas sensor is presented as a design example. © 2016 SPIE.

Merriam L.A.,University of Vermont | Locknar S.A.,Omega Optical Inc. | Girard B.M.,University of Vermont | Parsons R.L.,University of Vermont
American Journal of Physiology - Cell Physiology | Year: 2010

Prior studies indicated that a Ca2+-dependent release of ATP can be initiated from the soma of sympathetic neurons dissociated from guinea pig stellate ganglia. Previous studies also indicated that Ca2+-induced Ca2+ release (CICR) can modulate membrane excitability in these same neurons. As Ca2+ release from internal stores is thought to support somatodendritic transmitter release in other neurons, the present study investigated whether CICR is essential for somatic ATP release from dissociated sympathetic neurons. Caffeine increased intracellular Ca2+ and activated two inward currents: a slow inward current (SIC) in 85% of cells, and multiple faster inward currents [asynchronous transient inward currents (ASTICs)] in 40% of cells voltage-clamped to negative potentials. Caffeine evoked both currents when cells were bathed in a Ca2+-deficient solution, indicating that both were initiated by Ca2+ release from ryanodine-sensitive stores in the endoplasmic reticulum. Sodium influx contributed to generation of both SICs and ASTICs, but only ASTICs were inhibited by the presence of the P2X receptor blocker PPADs. Thus ASTICs, but not SICs, resulted from an ATP activation of P2X receptors. Ionomycin induced ASTICs in a Ca2+-containing solution, but not when it was applied in a Ca2+-deficient solution, demonstrating the key requirement for external Ca2+ in initiating ASTICs by ionomycin. Pretreatment with drugs to deplete the internal stores of Ca2+ did not block the ability of ionomycin or long depolarizing voltage steps to initiate ASTICs. Although a caffeine-induced release of Ca2+ from internal stores can elicit both SICs and ASTICs in dissociated sympathetic neurons, CICR is not required for the somatic release of ATP. Copyright © 2010 the American Physiological Society.

Barton J.B.,Omega Optical Inc. | Chanda S.,Omega Optical Inc. | Locknar S.A.,Omega Optical Inc. | Carver G.E.,Omega Optical Inc.
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2016

Compact optical systems can be fabricated by integrating coatings on fiber tips. Examples include fiber lasers, fiber interferometers, fiber Raman probes, fiber based spectrometers, and anti-reflected endoscopes. These interference filters are applied to exposed tips-either connectorized or cleaved. Coatings can also be immersed within glass by depositing on one tip and connecting to another uncoated tip. This paper addresses a fiber spectrometer for multispectral imaging-useful in several fields including biomedical scanning, flow cytometry, and remote sensing. Our spectrometer integrates serial arrays of reflecting fiber tips, delay lines between these elements, and a single element detector. © 2016 SPIE.

Rahmlow T.D.,Omega Optical Inc. | Fredell M.,Omega Optical Inc. | Chanda S.,Omega Optical Inc. | Johnson R.,Omega Optical Inc.
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2016

Narrow band-pass optical interference filters are used for a variety of applications to improve signal quality in laser based systems. Applications include LIDAR, sensor processing and free space communications. A narrow band width optical filter allows for passage of the laser signal while rejecting ambient light. The more narrow the bandwidth, the better the signal to noise. However, the bandwidth of a design for a particular application is typically limited by a number of factors including spectral shift over the operational angles of incidence, thermal shift over the range of operating temperature and, in the case of laser communication, rejection of adjacent laser channels. The trade-off of these parameters can significantly impact system design and performance. This paper presents design and material approaches to maximize the performance of narrow bandpass filters in the infrared. © 2016 SPIE.

Fredell M.A.,Omega Optical Inc. | Carver G.E.,Omega Optical Inc. | Chanda S.,Omega Optical Inc. | Locknar S.A.,Omega Optical Inc. | Johnson R.L.,Omega Optical Inc.
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2015

Ultra-narrow band pass filters are used to maximize LIDAR range and sensitivity. Alternate designs and measured fabrication results are presented for sub-nanometer band pass filters down to quarter nanometer bandwidths with 95% transmission. Thermal and angle sensitivity have been minimized. The filters are fabricated using dual source, plasma assisted magnetron sputtering. Single and multi-cavity designs are presented. © 2015 SPIE.

Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase II | Award Amount: 749.93K | Year: 2010

DESCRIPTION (provided by applicant): A fast, cost-effective multispectral confocal imaging capability for high-resolution mapping in vivo will be created during this project. This new approach will be based on fiber Bragg gratings, a technology not utilized previously in biomedical imaging, and will ultimately enable the early in vivo detection and treatment of cancer at the cellular level. The central innovation in this effort involves coupling a fast optical fiber-based spectrum analyzer with confocal spatial scanning optics - both interfaced with endoscopes for in-vivo detection and potential treatments. This fiber optic imaging spectrometer can acquire spectra in microseconds - fast enough to collect one spectrum for each resolved spot in a confocal spatial scan. As a result, datacubes containing spatial images for many wavelengths can be acquired in real-time. Multispectral confocal imaging in milliseconds will eliminate the effects of motion in biological systems. One can envisage acquiring multiple spatially registered simultaneous movies, comparing one channel with another (by subtraction or normalization). Further, biomedical researchers could use this new technology to catalog more extensive libraries of spectral images showing tumor growth, angiogenesis and subsequent metastasis. These enhanced libraries will lead to several applications in surgical pathology, oncology labs, and clinics. Clinicians will use the technology to take optical biopsies, perform treatments, and monitor long-term results. Patients will have access to real-time diagnosis and treatment. In addition to cancer interventions, other potential multispectral applications include: neural imaging, intra-cellular proteomics, micro-vascular testing, plaque detection, foodstuff testing, and the evaluation of pharmaceutical products. Our planned phases for this program will successively (a) create a fast fiber grating based spectrometer, (b) integrate the spectrometer with confocal scanning optics, (c) evaluate the integrated system with representative ex-vivo and in-vivo tissue samples (normal and abnormal), and (d) deliver the final product optimized for intrasurgical imaging to the biomedical community. The project will rely heavily on the unique and complementary expertise of the two participating groups/organizations.

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