Oman Medical College is the second medical college in the Sultanate of Oman, and is situated in Sohar in the North Batinha region.The premedical campus is located in Bowsher. First year is taught as a foundation course and second and third years are completed in Bowsher campus before the medical school years of Sohar campus. Some part of the coursework is also completed in Rustaq with students taking courses with doctors at Rustaq hospital. The associated hospital with the Sohar campus is Sohar hospital, one of the biggest governmental hospitals in the country. Total course work spans over a period of 7 years and the degree awarded is that of a Doctor of Medicine . The Bowsher campus also offers a degree in pharmacy . This degree spans over a period of 5 and a half years. Wikipedia.
Ahmad R.,Oman Medical College |
Ahsan H.,Jamia Millia Islamia University
Clinical and Experimental Medicine | Year: 2014
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease characterized by autoantibodies directed against various biomolecules. The initial immunogens that drive the development of SLE are unknown, but characteristics of the immune response in SLE suggest that it is an antigen-driven response, and a chromatin antigen could be one of the immunogens for the production of antinuclear antibodies (ANA) in SLE. Other factors implicated in the pathogenesis of SLE include nitrogen-free radicals such as nitric oxide and peroxynitrite. The free radical-mediated damage to proteins results in the modification of amino acid residues, cross-linking of side chains and fragmentation. The tyrosine residues in proteins are susceptible to attack by various reactive nitrogen intermediates, including peroxynitrite to form 3-nitrotyrosine (3-NT). The presence of nitrated proteins in vivo indicates that peptides derived from the proteolytic degradation of modified proteins could serve as neoantigens. Histones are highly conserved proteins that are rich in basic amino acids lysine and arginine. Autoantibodies against histones and anti-DNA antibodies are present in SLE. The anti-DNA autoantibodies coexist with anti-histone autoantibodies and may react with chromatin-associated histones and histone complexes. Elevated levels of reactive nitrogen species (RNS) in SLE patients suggest a possible role in the pathogenesis of the disease. The alteration of proteins resulting from photomodification or peroxynitrite could lead to the development of antibodies. Therefore, the modified proteins or photoadducts could have important implications in autoimmunity, and understanding the pathophysiology of peroxynitrite-modified biomolecules could lead to a better understanding of autoimmune phenomenon in SLE. © 2012 Springer-Verlag Italia.
Khaket T.P.,Sb Spg Institute Of Biomedical Science And Research |
Ahmad R.,Oman Medical College
Applied Biochemistry and Biotechnology | Year: 2011
Hemoglobin is the iron-containing oxygen transporting metalloprotein in the red cells of blood in mammals and other animals. Hemoprotein-mediated oxidative stress is thought to play a major role in pathophysiology of cerebral hemorrhage, blast pressure injury, crush injury, myocardial ischemia reperfusion injury. Hemoglobin undergoes oxidation-reduction reactions that lead to both generation and consumption of highly reactive oxygen and nitrogen species. In the present study, hemoglobin molecule wastreated with hydrogen peroxide and the modification so incurred was analyzed by UV spectra, sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and detection of carbonyl content. Our observations suggest that carbonyl content increases with increase in concentration of hydrogen peroxide. Production of hydroxyl radical was assessed by using benzoate degradation analysis. Our results was in tandem with the fact that hemoglobin on treatment with hydrogen peroxide rapidly generates free-radical species that can degrade benzoate to thiobarbituric acid reactive material which on reacting with thiobarbituric acid gives color. The increase in absorbance of ROS-modified hemoglobin at 532 nm shows the increase in benzoate degradation, which is a parameter of hydroxyl radical formation with increase in concentration of hydrogen peroxide. Modified hemoglobin was treated with catalase, mannitol, thiourea, glutathion, sodium benzoate and their effect were detected by spectroscopy and SDS-PAGE (12%). Substantial scavenging effect of aforementioned antioxidants reiterates the formation of hydroxyl radical. Catalase shows the maximum scavenging effect followed by thiourea and mannitol. © Springer Science+Business Media, LLC 2011.
Alhakmani F.,Oman Medical College |
Kumar S.,Rv Northland Institute Of Pharmacy |
Khan S.A.,Oman Medical College
Asian Pacific Journal of Tropical Biomedicine | Year: 2013
Objective: To evaluate and compare the antioxidant potential and anti-inflammatory activity of ethanolic extract of flowers of Moringa oleifera (M. oleifera) grown in Oman. Methods: Flowers of M. oleifera were collected in the month of December 2012 and identified by a botanist. Alcoholic extract of the dry pulverized flowers of M. oleifera were obtained by cold maceration method. The ethanolic flower extract was subjected to preliminary phytochemical screening as the reported methods. Folin-Ciocalteu reagent was used to estimate total phenolic content. DPPH was used to determine in-vitro antioxidant activity and anti-inflammatory activity of flowers was investigated by protein denaturation method. Results: Phytochemical analysis of extract showed presence of major classes of phytochemicals such as tannins, alkaloids, flavonoids, cardiac glycosides etc. M. oleifera flowers were found to contain 19.31 mg/g of gallic acid equivalent of total phenolics in dry extract but exhibited moderate antioxidant activity. The anti-inflammatory activity of plant extract was significant and comparable with the standard drug diclofenac sodium. Conclusions: The results of our study suggest that flowers of M. oleifera possess potent anti-inflammatory activity and are also a good source of natural antioxidants. Further study is needed to identify the chemical compounds responsible for their anti-inflammatory activity. © 2013 Asian Pacific Tropical Biomedical Magazine.
Mullaicharam A.R.,Oman Medical College |
Deori G.,Oman Medical College |
Uma Maheswari R.,SASTRA University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013
Food is a major determinant of health that is directly under our control. In fact, there is a growing consensus of individuals promoting and living a lifestyle where food is used as a form of medicine. Healthy foods, such as fresh fruits and vegetables or meats, dairy and high fiber carbohydrates, contain the full amount of vitamins and minerals required on a daily basis. Apart from helping the body perform at the optimum level, these antioxidants, vitamins, and mineralsalso contribute to preventing overall aging as well as chronic diseases such as cancer and heart disease Nuts and Seeds one among the natural resource contributes to the essentials in combating disease. This article highlights the use of Fenugreek in the maintenance of health.
Alhakmani F.,Oman Medical College |
Khan S.A.,Oman Medical College |
Ahmad A.,King Abdulaziz University
Asian Pacific Journal of Tropical Biomedicine | Year: 2014
Objective: To perform phytochemical screening and to evaluate the in-vitro antioxidant and anti-inflammatory activities of ethanolic extract of seeds and fruits of Zizyphus spina-christi (ZSC) growing in Oman. Methods: Alcoholic extract of the dry powdered seeds and fruits of ZSC was obtained by cold maceration method and was subjected to preliminary phytochemical screening. Total phenolic content were estimated by using Folin-Ciocalteu reagent and 1,1-diphenyl-2-picrylhydrazyl (DPPH) was used to determine in-vitro antioxidant activity of plant extracts. Anti-inflammatory activity was investigated by protein denaturation method. Results: Phytochemical analysis of both the extracts revealed the presence of major classes of phytochemicals such as tannins, alkaloids, flavonoids, cardiac glycosides etc. ZSC seeds were found to contain the highest total phenolics but ZSC fruits exhibited the maximum antioxidant activity. The anti-inflammatory activity of both parts of the plant extract was significant and comparable with the standard anti-inflammatory drug, diclofenac. Conclusions: Based on the results of this pilot study, it can be concluded that ZSC is a good source of natural antioxidants which can be used to prevent progression of many chronic diseases. Further detailed phytochemical studies are needed to identify the chemical compounds responsible for exhibiting potent anti-inflammatory activity. © 2014 by the Asian Pacific Journal of Tropical Biomedicine.
Pharmacophore modeling, homology modeling, and in silico screening reveal mammalian target of rapamycin inhibitory activities for sotalol, glyburide, metipranolol, sulfamethizole, glipizide, and pioglitazone
Khanfar M.A.,University of Jordan |
Abukhader M.M.,Oman Medical College |
Alqtaishat S.,University of Jordan |
Taha M.O.,University of Jordan
Journal of Molecular Graphics and Modelling | Year: 2013
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase and member of the PI3K-related kinase (PIKK) family. It plays a central role in integrating signals from metabolism, energy homeostasis, cell cycle, and stress response. Aberrant PI3K/mTOR activation is commonly observed in diseases such as cancer, diabetes and Alzheimer's disease. Accordingly, we developed common feature binding hypotheses for a set of 6 potent mTOR antagonists. The generated models were validated using receiver operating characteristic (ROC) curve analyses. To gain better insight into ligand-mTOR interactions, a homology model for the kinase domain of mTOR was built using the crystallographic structure of PI3Kγ as template. The optimal pharmacophore model was further improved based on detailed docking studies of potent training compound in the homology model. The modified binding model was employed as 3D search query to screen our in-house-built database of established drugs. Subsequent in vitro screening of captured hits showed that six of them have submicromolar to low micromolar bioactivities, namely, glyburide, metipranolol, sulfamethizole, glipizide, pioglitazone, and sotalol. © 2013 Elsevier Inc.
Abukhader M.M.,Oman Medical College
Asian Journal of Pharmaceutical and Clinical Research | Year: 2014
Objective: The study was conducted to evaluate the quality of the medical prescription form which is used by prescribers who are working in different health care facilities in Muscat, Oman in terms of preprinted contents as well as to study prescribers attitude towards these forms. Methods: for research purposes only, photocopies of 74 blank prescription forms were obtained from 74 health care facilities (71 private and 3 government) and 888 prescriptions were collected, reviewed and analyzed. Results: medical prescription forms collected in the study showed an inconsistency in their preprinted contents as well as an attitude variation amongst prescribers towards the preprinted contents of the prescription forms was recorded. Only 13.51% of the 74 prescription forms are of an ideal standard quality and 42.45% of the 888 prescriptions showed prescribers adherence in completely filling in the prescription forms. Conclusion: observations reported in this study regarding the prescription form quality and the prescriber attitude towards these forms could affect the communication between the prescriber and the recipient which ultimately influence patient safety. The policy adopted by the management of the health care facilities in Muscat could be a major contributor to these observations.
Abukhader M.M.,Oman Medical College
Mediterranean Journal of Nutrition and Metabolism | Year: 2015
BACKGROUND: Snack foods; crisps and biscuits, and beverages; fruit juices and soft drinks, are some of the most commonly consumed products by children of school age worldwide. OBJECTIVE: The aim of this study is to investigate if snack foods and beverages are suitable for consumption by children of school age through recording and comparing the nutritional information presented on the nutrition panel such as energy, protein, total carbohydrates and total fat for these products. METHODS: The nutritional information from 56 products sold in different supermarket out lets across Muscat, the capital city of Oman, was collected and statistically analysed using the mean and the percentage of Recommended Daily Intake. RESULTS: Based on the percentage of Recommended Daily Intake of energy and nutrients, crisps offer higher amounts of energy and total fat for children when compared to biscuits. Meanwhile, biscuits offer lower amount of energy than crisps but offer a higher amount of total carbohydrates for children. Regarding fruit juices and soft drinks, the former offer higher amount of energy than the later but both, however, offer comparable amounts of total carbohydrates. CONCLUSION: Upon comparing the nutritional information of the products studied and considering their nutritional benefits and health risks, it seems that biscuits are suitable choice for children. © 2015 - IOS Press and the authors. All rights reserved.
Al Junaibi R.M.,Oman Medical College |
Khan S.A.,Oman Medical College
Journal of Applied Pharmaceutical Science | Year: 2011
Breast cancer is the most common cancer among women in Oman and worldwide. Breast cancer patients in Oman are commonly presented at a relatively young age and with an advanced stage of disease. This could be due to lack of awareness, knowledge and beliefs about breast cancer and its management among females. The present pilot study assessed the awareness and knowledge about the screening method (Breast self examination), risk factors and symptoms of breast cancer among 157 university female students in Muscat region. The study results indicated that female students were well informed and aware about breast cancer in general but their knowledge of breast cancer symptoms was better than the risk factors of breast cancer. The study also revealed that majority of the students knew that Breast self examination (BSE) is the most common and easy method of breast cancer detection but their knowledge regarding frequency and the appropriate time to practice BSE was not very good. Thus, more educational programs could be designed to provide comprehensive information on breast cancer and BSE to improve women's knowledge and awareness which can help in the early detection and reporting of breast cancer for the better treatment.
Abukhader M.,Oman Medical College
Pharmacognosy Reviews | Year: 2013
Thymoquinone (TQ) is The bioactive phytochemical constituent of The seeds oil of Nigella sativa. In vitro and in vivo research has Thoroughly investigated The anticancer effects of TQ against several cancer cell lines and animal models. As a result, a considerable amount of information has been generated from research Thus providing a better understanding of The anti-proliferating activity of This compound. Therefore, it is appropriate That TQ should move from Testing on The bench To clinical experiments. The purpose of This review is To highlight The potential of TQ as an anticancer agent and The chances of This compound in The clinical Treatment of cancer, with special attention on breast cancer Treatment.