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Râmnicu Vâlcea, Romania

Soare M.-L.,Polytechnic University of Bucharest | Ungureanu E.-M.,Polytechnic University of Bucharest | Georgescu E.,Research Center Oltchim | Birzan L.,Romanian Academy of Sciences
Journal of the Serbian Chemical Society

This work was devoted to the synthesis and characterization of new indolizine derivatives. Particular attention was paid to electrochemical investigations by cyclic voltammetry and differential pulse voltammetry. The redox processes for each compound were established, analyzed and assigned to the particular functional groups at which they occur. This assignment was based on detailed comparisons between the electrochemical behaviour of the compounds, the similarities in their structure, as well as substituent effects. Source

Tatu M.-L.,Polytechnic University of Bucharest | Georgescu E.,Research Center Oltchim | Boscornea C.,Polytechnic University of Bucharest | Popa M.-M.,Romanian Academy of Sciences | Ungureanu E.-M.,Polytechnic University of Bucharest
UPB Scientific Bulletin, Series B: Chemistry and Materials Science

This work is devoted to the synthesis and spectral characterization of 1-[7- (4-nitrobenzoyl)-3-(biphenyl-4-yl)pyrrolo[1,2-c]pyrimidin-5-yl]ethanone. The investigations were performed by absorbance and fluorescence. Following spectrophotometric analysis the molar extinction coefficient, quantum yieldand Stokes shiftshave been calculated. Source

Caira M.R.,University of Cape Town | Dumitrascu F.,Romanian Academy of Sciences | Georgescu E.,Research Center Oltchim | Georgescu F.,Research Center Oltchim | Popa M.M.,Romanian Academy of Sciences
Revue Roumaine de Chimie

The new pyrroles 8a,b were obtained by one-pot reaction from N1-quinazolinum bromides and non-symmetrical acetylenic dipolarophiles. Structural characterizations were based on IR and NMR spectroscopy as well as on single crystal X-ray diffraction. Source

Georgescu E.,Research Center Oltchim | Georgescu F.,Research Center Oltchim | Popa M.M.,Romanian Academy of Sciences | Draghici C.,Romanian Academy of Sciences | And 2 more authors.
ACS Combinatorial Science

Herein is reported a simple and efficient one-pot three-component synthesis of pyrrolo[1,2-c]pyrimidine derivatives starting from various substituted pyrimidines, 2-bromoacetophenones, and electron deficient alkynes in epoxides acting both as reaction medium and HBr scavanger. This method proved to be very lucrative and avoids formation of ylide inactivation products. The synthesis represents an environmentally benign alternative to classical methods. The new library of compounds was briefly characterized regarding the improved Lipinski rule to asses the potential drug-likeness of the compounds. The majority of compounds are statisfing the Lipinski rule. © 2012 American Chemical Society. Source

Georgescu E.,Research Center Oltchim | Nicolescu A.,Romanian Academy of Sciences | Nicolescu A.,Petru Poni Institute of Macromolecular Chemistry | Georgescu F.,Teso Spec SRL | And 5 more authors.
Beilstein Journal of Organic Chemistry

The one-pot three-component reactions of 1-substituted benzimidazoles with ethyl bromoacetate and electron-deficient alkynes, in 1,2-epoxybutane, gave a variety of pyrrolo[1,2-a]quinoxalin-4-ones and pyrrolo[1,2-a]benzimidazoles. The influence of experimental conditions on the course of reaction was investigated. A novel synthetic pathway starting from benzimidazoles unsubstituted at the five membered ring, alkyl bromoacetates and non-symmetrical electron-deficient alkynes in the molar ratio of 1:2:1, in 1,2-epoxybutane at reflux temperature, led directly to pyrrolo[1,2-a]quinoxalin-4-ones in fair yield by an one-pot threecomponent reaction. © 2014 Georgescu et al. Source

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