Old Dominion University is a public research university in Norfolk, Virginia, United States. It was established in 1930 as the Norfolk Division of the College of William & Mary. ODU awarded its first bachelor's degrees in 1956, became Old Dominion College in 1962, and attained university status in 1969. ODU offers a full range of degree programs and is one of the nation's largest providers of online distance learning courses. Old Dominion University derives its name from one of Virginia's state nicknames, "The Old Dominion", given to the state by King Charles II of England for remaining loyal to the crown during the English Civil War. Wikipedia.
Sundin T.,Old Dominion University
Expert reviews in molecular medicine | Year: 2012
Telomeres are stretches of repeated DNA sequences located at the ends of chromosomes that are necessary to prevent loss of gene-coding DNA regions during replication. Telomerase - the enzyme responsible for immortalising cancer cells through the addition of telomeric repeats - is active in ~90% of human cancers. Telomerase activity is inhibited by various phytochemicals such as isoprenoids, genistein, curcumin, epigallocatechin-3-gallate, resveratrol and others. Human TERT (telomerase reverse transcriptase - the rate-limiting component of telomerase), heat shock protein 90, Akt, p70 S6 kinase (S6K) and mammalian target of rapamycin (mTOR) form a physical and functional complex with one another. The inclusion of Akt, mTOR and S6K in the TERT complex is compelling evidence to support mTOR-mediated control of telomerase activity. This review will define the role of mTOR, the master regulator of protein translation, in telomerase regulation and provide additional insights into the numerous ways in which telomerase activity is hindered by phytochemicals.
Li L.,Old Dominion University
Enterprise Information Systems | Year: 2012
Supply chain collaboration has received increasing attention from scholars and practitioners in recent years. However, our understanding of how enterprise information technology facilitates supply chain collaboration is still very limited, especially with regard to Chinese enterprise ownerships such as state-owned firms, joint-venture firms and local village-owned firms. This paper extends the theory established in enterprise information technology (IT) and supply chain collaboration literature and relates it with coordination in China-linked supply chain. Drawing upon an empirical study from 177 Chinese companies, we provide three major findings: (i) uncovered the importance of leveraging enterprise IT through supply chain collaboration; (ii) identified the relationship between enterprise ownership and enterprise technology use and supply chain collaboration in China-linked supply chain and (iii) illustrated effects of supply chain collaborative activities on operational and market performance. © 2012 Taylor and Francis Group, LLC.
Xu L.D.,Old Dominion University
IEEE Transactions on Industrial Informatics | Year: 2011
Rapid advances in industrial information integration methods have spurred tremendous growth in the use of enterprise systems. Consequently, a variety of techniques have been used for probing enterprise systems. These techniques include business process management, workflow management, Enterprise Application Integration (EAI), Service-Oriented Architecture (SOA), grid computing, and others. Many applications require a combination of these techniques, which is giving rise to the emergence of enterprise systems. Development of the techniques has originated from different disciplines and has the potential to significantly improve the performance of enterprise systems. However, the lack of powerful tools still poses a major hindrance to exploiting the full potential of enterprise systems. In particular, formal methods and systems methods are crucial for modeling complex enterprise systems, which poses unique challenges. In this paper, we briefly survey the state of the art in the area of enterprise systems as they relate to industrial informatics. © 2011 IEEE.
Ezer T.,Old Dominion University
Geophysical Research Letters | Year: 2013
Impacts of ocean dynamics on spatial and temporal variations in sea level rise (SLR) along the U.S. East Coast are characterized by empirical mode decomposition analysis and compared with global SLR. The findings show a striking latitudinal SLR pattern. Sea level acceleration consistent with a weakening Gulf Stream is maximum just north of Cape Hatteras and decreasing northward, while SLR driven by multidecadal variations, possibly from climatic variations in subpolar regions, is maximum in the north and decreasing southward. The combined impact of sea level acceleration and multidecadal variations explains why the global mean SLR obtained from ∼20 years of altimeter data is about twice the century-long global SLR obtained from tide gauge data. The sea level difference between Bermuda and the U.S. coast is highly correlated with the transport of the Atlantic Overturning Circulation, a result with implications for detecting past and future climatic changes using tide gauge data. ©2013. The Authors. Geophysical Research Letters published by Wiley on behalf of the American Geophysical Union.
Darby D.A.,Old Dominion University
Nature Geoscience | Year: 2014
Sea ice in the Arctic Ocean is a key component of the modern climate system, but less is known about the evolution of Arctic sea ice throughout Earth's history, particularly in warmer climate states. Following early Palaeogene greenhouse conditions, seasonal sea ice in the Arctic developed during a period of relative cooling in the middle Eocene, some 47.5 million years ago. However, perennial sea ice has only been documented as recently as 18 million years ago. Here I document the provenance of iron grains in marine sediments from the central Arctic Ocean, and show that during several intervals, beginning about 44 million years ago, they were carried from distal Arctic shelf sources. The grains are too coarse to have been delivered by ocean currents or aeolian transport, and therefore must have been rafted by sea ice. Because grains entrained from the shelf sources would need to drift for more than one year to reach the depositional site, I conclude that sea ice must have persisted throughout the year. However, the presence of grains from these distal sources only occur in intervals of less than 100,000 years in the oldest part of the records, suggesting that perennial sea ice existed only ephemerally until 36.7 million years ago. © 2014 Macmillan Publishers Limited.