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Oklahoma City, OK, United States

Northwestern Oklahoma State University is a university in Alva, Oklahoma, United States, with satellite campuses in Enid and Woodward. A state university, it offers both bachelor's and master's degrees. Wikipedia.

Mihai C.,University of Illinois at Chicago | Mihai C.,Northwestern Oklahoma State University | Yue X.,University of Illinois at Chicago | Zhao L.,Ohio State University | And 5 more authors.
New Journal of Chemistry

Phosphatidylinositol-specific phospholipases C (PI-PLCs) are important enzymes participating in transmembrane signal transduction. The structures of the two major species of these enzymes: bacterial Ca2+-nondependent enzyme from B. cereus and mammalian Ca2+-dependent PLCδ1 from rat brain in the complexes with the polar head groups of their substrates have been previously solved. Although these structures show few differences as compared to free enzymes, there is a compelling evidence that full catalytic activity of PI-PLC necessitates interaction of the enzyme with the entire substrate, including the hydrophobic fatty acid chains. In this work we develop new tightly binding and cleavage-resistant analogs of phosphatidylinositol, using relatively minor modifications of the structure. Two synthesized analogs, 2-amino-2-deoxy-PI (8) and the conformationally constrained analog (10) had binding affinities (K i) in 10 μM range. 15N-1H HSQC NMR spectra of uniformly 15N-labeled bacterial Ca2+-nondependent and Ca2+-dependent phospholipases C, btPLC and saPLC1, respectively, displayed changes upon ligand binding that suggest an occurrence of a conformational change. © 2010 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique. Source

Mathe K.,Northwestern Oklahoma State University
Journal of Foodservice Business Research

With the increasing need to maintain safe food practices in restaurants, this article explores the relationships between unit food safety performance, labor costs, and revenues in quick service restaurants. Namely, the goals of this study were to explore associations between food safety performance and restaurant revenues, labor costs and restaurant revenues as well as the relationship between labor costs and food safety performance. Using a theoretical foundation of organizational learning as support for lowering labor costs, research questions were answered using ANCOVAs, independent t-tests and Pearson correlations. Incorporating data from 1,190 quick service restaurant units, the study found relationships among the variables in that lower labor costs typically result in greater financial and food safety performance. Moreover, greater food safety performance also tended to result in greater financial performance. Theoretical and practical implications for the restaurant industry are discussed. © 2012 Copyright Taylor & Francis Group, LLC. Source

Johnke R.M.,East Carolina University | Sattler J.A.,Northwestern Oklahoma State University | Allison R.R.,21st Century Oncology
Future Oncology

Only two radioprotective compounds, amifostine and palifermin, currently have the US FDA approval for use in radiation therapy. However, several agents have been reported that show therapeutic promise. Many of these agents are free radical scavengers/antioxidants. Superoxide dismutase and superoxide dismutase mimetics, nitroxides and dietary antioxidants are all being investigated. Recently, alternative strategies of drug development have been evolving, which focus on targeting the series of cellular insult recognition/repair responses initiated following radiation. These agents, which include cytokines/growth factors, angiotensin-converting enzyme inhibitors and apoptotic modulators, show promise of having significant impact on the mitigation of radiation injury. Herein, we review current literature on the development of radioprotectors with emphasis on compounds with proven or potential usefulness in radiation therapy. © 2014 Future Medicine Ltd. Source

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