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Oklahoma City, OK, United States

Oklahoma Christian University is a private comprehensive coeducational Christian liberal arts university founded in 1950 by members of the Churches of Christ. Oklahoma Christian University is located on a 240-acre campus in Oklahoma City, in the U.S. state of Oklahoma. Enrollment for the fall 2014 semester was a record 2,479 students. OC is ranked among the best "Regional Universities" in the 16-state West region by U.S. News and World Report and is listed by the Princeton Review as one of the best "Best Western Colleges." The University reported a 45% acceptance rate for fall 2012 applicants. Wikipedia.

Fiello M.,University of Southern Mississippi | Mikell A.T.,Oklahoma Christian University | Moore M.T.,U.S. Department of Agriculture | Cooper C.M.,U.S. Department of Agriculture
Bulletin of Environmental Contamination and Toxicology | Year: 2014

The fecal coliform, Escherichia coli, is a historical organism for the detection of fecal pollution in water supplies. The presence of E. coli indicates a potential contamination of the water supply by other more hazardous human pathogens. In order to accurately determine the presence and degree of fecal contamination, it is important that standard methods approved by the US Environmental Protection Agency are designed to determine the presence of E. coli in a water supply, and distinguish E. coli from other coliform bacteria (e.g. Citrobacter, Klebsiella and Enterobacter). These genera of bacteria are present not only in fecal matter, but also in soil and runoff water and are not good indicators of fecal contamination. There is also ambiguity in determining a positive result for fecal coliforms on M-FC filters by a blue colony. When all variations of blue, including light blue or glossy blue, were examined, confirmation methods agreed with the positive M-FC result less often than when colonies that the technician would merely call "blue", with no descriptors, were examined. Approximately 48 % of M-FC positive colonies were found to be E. coli with 4 methylumbelliferyl-β-D-glucuronide (MUG), and only 23 % of samples producing a positive result on M-FC media were found to be E. coli using API-20E test strips and current API-20E profiles. The majority of other M-FC blue colonies were found to be Klebsiella or were unidentifiable with current API-20E profiles. Two positive M-FC colonies were found to be Kluyvera with API-20E, both of which cleaved MUG and produced fluorescence under UV light, a characteristic used to differentiate E. coli from other fecal coliforms. © 2014 Springer Science+Business Media New York. Source

Whaley P.W.,Oklahoma Christian University
ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE) | Year: 2012

A theoretical model for material fatigue is described using irreversible thermodynamics to quantify fatigue damage by the generation of microplastic entropy. The microplastic entropy generated quantifies the microplastic deformation, commonly accepted as the mechanism of fatigue damage in polycrystalline materials. A stochastic model for microplastic deformation is utilized to calculate the expected values of tensile stress - strain, cyclic stress - strain, microplastic strain energy density and the microplastic entropy generated. When the cumulative microplastic entropy generated in cyclic loading exceeds the critical microplastic entropy threshold calculated from tensile tests, failure occurs. Calculated fatigue life with 99% tolerance limits (99% confidence) compares favorably to data for 6061-T6 aluminum rod and sheet specimens. Model parameters are determined from tensile tests and simple cyclic tests, decreasing the high cost of fatigue testing for parameter identification. This new theory has the potential to significantly decrease the cost of characterizing the fatigue properties of new materials. Copyright © 2012 by ASME. Source

Himelhoch S.,University of Maryland Baltimore County | Medoff D.,University of Maryland Baltimore County | Maxfield J.,Oklahoma Christian University | Dixon L.,New York State Psychiatric Institute | And 3 more authors.
AIDS and Behavior | Year: 2013

This pilot randomized controlled trial evaluated a previously developed manualized telephone based cognitive behavioral therapy (T-CBT) intervention compared to face-to-face (f2f) therapy among low-income, urban dwelling HIV infected depressed individuals. The primary outcome was the reduction of depressive symptoms as measured by the Hamliton rating scale for depression scale. The secondary outcome was adherence to HAART as measured by random telephone based pill counts. Outcome measures were collected by trained research assistants masked to treatment allocation. Analysis was based on intention-to-treat. Thirty-four participants met eligibility criteria and were randomly assigned to receive T-CBT (n = 16) or f2f (n = 18). There was no statistically significant difference in depression treatment outcomes comparing f2f to T-CBT. Within group evaluation demonstrated that both the T-CBT and the f2f psychotherapy groups resulted in significant reductions in depressive symptoms. Those who received the T-CBT were significantly more likely to maintain their adherence to antiretroviral medication compared to the f2f treatment. None of the participants discontinued treatment due to adverse events. T-CBT can be delivered to low-income, urban dwelling HIV infected depressed individuals resulting in significant reductions in depression symptoms and improved adherence to antiretroviral medication. Trial Registry: Clinical Trial.gov identifier: NCT01055158. © 2013 Springer Science+Business Media New York. Source

Whitby P.W.,The University of Oklahoma Health Sciences Center | VanWagoner T.M.,The University of Oklahoma Health Sciences Center | VanWagoner T.M.,Oklahoma Christian University | Seale T.W.,The University of Oklahoma Health Sciences Center | And 2 more authors.
BMC Genomics | Year: 2013

Background: Haemophilus influenzae is a significant cause of childhood otitis media, and also has an absolute growth requirement for heme. Recent microarray studies using three H. influenzae isolates were used to propose a putative core of genes responsive to iron and heme levels. Included in the core modulon were thirty seven genes that are preferentially expressed under iron/heme limitation, most of which are directly involved with iron and or heme acquisition. In this report, the core iron/heme modulon was further refined following microarray analysis of two additional nontypeable H. influenzae isolates from patients with otitis media. The transcriptional status of the genes comprising the refined iron/heme core modulon was then assessed in vivo, in a chinchilla model of otitis media. These in vivo experiments were performed to address the hypothesis that iron and heme regulated genes are both highly expressed in vivo and important, during clinical infection.Results: Microarray analysis of two additional H. influenzae strains resulted in the definition of a core of iron/heme responsive genes. This core consisted of 35 genes maximally expressed under heme restriction and a further 20 genes maximally expressed in heme replete conditions. In vivo studies were performed with two nontypeable H. influenzae strains, 86-028NP and HI1722. The majority of operons identified as members of the core modulon by microarray were also actively upregulated in the chinchilla ear during otitis media. In 86-028NP, 70% of the operons were significantly upregulated while in HI1722 100% of the operons were upregulated in samples recovered from the chinchilla middle ear.Conclusion: This study elucidates a conserved core of H. influenzae genes the transcription of which is altered by the availability of iron and heme in the growth environment, and further assesses transcription of these genes in vivo. Elucidation of this modulon allows for identification of genes with unrecognized roles in iron/heme acquisition or homeostasis and/or potential roles in virulence. Defining these core genes is also of potential importance in identifying targets for therapeutic and vaccine designs since products of these genes are likely to be preferentially expressed during growth in iron/heme restricted sites of the human body. © 2013 Whitby et al.; licensee BioMed Central Ltd. Source

Tucker G.,Oklahoma Christian University
International Symposium on Technology and Society, Proceedings | Year: 2016

As society teeters on the verge of robotic automatons performing complex functions in every aspect of human existence, urgent questions arise concerning human accountability for ethics as they design robots capable of making moral decisions. The aim of this study considers a path toward an ethical paradigm for morally sentient robots. In order to determine the extent of human accountability, an ethical spectrum of robots is discussed. While seeking to define functional good in a robotic setting, the nature and degree of robotic sentience is explored. Subsequently, the divergent positions regarding an ethical paradigm for morally sentient robots must be examined. Following these experts' opinions, an analysis of a human/dog model for human/robot relations is explained. The constructs that frame the human/robot dynamic include Asimov's Laws, as well as necessary design considerations. An ethical paradigm results from a study of Plato's Republic through which emerges a means to find good for robots in a functional setting. © 2015 IEEE. Source

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