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Objective: The aim of the study was to compare the results of estimating glomerular filtration (GF) obtained from creatinine, based on the 4-variable MDRD equation and the Lund-Malmö equation, with the results of glomerular filtration estimates obtained from cystatin C based on the Grubb equation. Settings: Department of Clinical Biochemistry St. Anne's University Hospital Brno. Material and methods: Single samples were taken from a set of 449 patients at the nephrology outpatients' department, in which both serum creatinine and cystatin C concentration were analysed. Differences between GF estimates calculated by Grubb and MDRD equations and between GF estimates calculated by Grubb and Lund-Malmö equations were tested. The null hypothesis was that the mean difference between compared GF estimates was statistically significantly different from zero. The calculated estimates of GF were evaluated by paired samples t-test and by variance ratio test (F-test). Results: In the groups of men and women with GF ≤ 1.0 ml/s calculated by Grubb equation, the results were in better agreement with estimates of GF obtained from the Lund-Malmö equation (p > 0.23) than with estimates of GF obtained from the MDRD equation (p ≤ 0.169). Further, in groups of men and women with GF 0.8-1.2 ml/s calculated by Grubb equation, results were in better agreement with GF obtained from the Lund-Malmö equation (p = 0.448) than with GF results obtained from the MDRD equation (p = 0.0015). In groups of men and women with GF > 1.0 ml/s (Grubb equation) these estimates were in better agreement with those obtained from the MDRD equation than results obtained from the Lund-Malmö equation. Conclusion: In the threshold-to-reduced interval values for GF estimates calculated by Grubb equation, results were in better agreement with estimates calculated by the Lund-Malmö equation than with those calculated by the MDRD equation. Source


Ryzhov S.B.,OKB | Mokhov V.A.,OKB | Nikitenko M.P.,OKB | Chetverikov A.E.,OKB | And 3 more authors.
NATO Science for Peace and Security Series B: Physics and Biophysics | Year: 2010

The task of constructing NPPs as the objects of regional power industry is included into the Federal Target Program on nuclear power technologies of new generation for the period till 2020. Such NPPs are considered as perspective sources of energy for solution of the problems concerning provision of electric energy, household and industrial heat to the regions with limited capabilities of the power grid. OKB "GIDROPRESS" present the conceptual study of RP design for the Unit of 600 MW (el.) power, taking into account their long-term experience in the field of development and operation of VVER reactor plants. © 2010 Springer Science+Business Media B.V. Source

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