Okayama, Japan

Okayama University of Science is a private university in Okayama, Okayama, Japan, established in 1964. Wikipedia.

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Kondo E.,Okayama University of Science
Journal of clinical and experimental hematopathology : JCEH | Year: 2016

High-dose chemotherapy supported by autologous stem cell support/transplantation (HDT/ASCT) has been a standard of care over the last two decades in patients with relapsed or refractory(R/R) diffuse large B-cell lymphoma (DLBCL), which is sensitive to salvage chemotherapy. HDT/ASCT for high-risk DLBCL in upfront setting remains controversial, so it is not recommended for clinical practice. Various promising salvage chemotherapy regimens have been reported in phase 2 studies; however, two large randomized phase 3 studies showed similar efficacy of R-ICE vs. R-DHAP and R-GDP vs. R-DHAP. Since the registry data shows feasibility and efficacy of HDT/ASCT in elderly R/R DLBCL patients, older age (> 65 years) itself is not a contraindication for HDT/ASCT. Rituximab maintenance failed to demonstrate a significant benefit compared with observation only after HDT/ASCT. While sensitive R/R DLBCL might be cured by HDT/ASCT even in third-line therapy, the prognosis of insensitive R/R DLBCL is extremely poor. Further study to establish treatment strategies for high-risk patients defined by prognostic factors or biomarkers, and insensitive patients is warranted.

Sato Y.,Okayama University of Science
Journal of clinical and experimental hematopathology : JCEH | Year: 2012

IgG4-related disease is a recently proposed clinical entity with several unique clinicopathological features. A chronic inflammatory state with marked fibrosis, which can often be mistaken for malignancy, especially by clinical imaging analyses, unifies these features. In the present report, we describe a case of IgG4-producing mucosa-associated lymphoid tissue lymphoma mimicking IgG4-related disease. The patient was a 55-year-old male who was being followed for right orbital tumor over 1.5 years. The lesion had recently increased in size, so a biopsy was performed. Histologically, the lesion was consistent with IgG4-related disease ; however, IgG4+ plasma cells showed immunoglobulin light-chain restriction and immunoglobulin heavy chain gene rearrangement was detected in the lesion. Therefore, the lesion was diagnosed as IgG4-producing mucosa-associated lymphoid tissue lymphoma. In conclusion, in histological diagnosis of IgG4-related disease, it is important to examine not only IgG4-immunostain but also immunoglobulin light-chain restriction.

Morishige K.,Okayama University of Science
Journal of Physical Chemistry C | Year: 2011

To examine the effect of pore-wall structure on freezing and melting behavior of a confined material in mesopores, we measured X-ray diffraction patterns from Kr confined in two kinds of ordered mesoporous carbons with hexagonally shaped pores, compared with ordered mesoporous silica with cylindrical pores, during freezing and melting processes. The ordered mesoporous carbon possesses crystalline carbon walls with turbostratic stacking structure, whereas the pore walls of the mesoporous silica are amorphous. Large depressions in melting point of the confined Kr were observed for both the ordered mesoporous carbon and silica. For the Kr confined in the amorphous pores of the mesoporous silica, thermal cycling showed pronounced hysteresis between freezing and melting, in agreement with previous results. On the other hand, for the Kr confined in the crystalline pores of the mesoporous carbon, freezing and melting took place almost reversibly. © 2011 American Chemical Society.

Morishige K.,Okayama University of Science
Journal of Physical Chemistry C | Year: 2011

To examine the origin of the lack of hysteresis between freezing and melting for Kr confined in the hexagonal pores with crystalline carbon walls, we measured X-ray diffraction patterns from Kr adsorbed in the ordered mesoporous carbon as a function of pore filling at three temperatures in the vicinity of the freezing point of a confined phase. The results clearly indicate that the structure of the first layer adjacent to the pore walls formed at a temperature below the freezing point is compatible with the 3D structure of the confined bulk crystal. In addition, the first bilayer adjacent to the crystalline walls of the mesoporous carbon still keeps its crystallinity at a temperature 6 K higher than the freezing point. Therefore, for a liquid Kr confined in the crystalline carbon pores, the crystalline bilayer film that is commensurate with the bulk structure of the confined solid Kr is already in place at a boundary between the liquid and the carbon pore walls at the equilibrium freezing point and thus plays a role as a critical nucleus in freezing of the interior phase. © 2011 American Chemical Society.

Morishige K.,Okayama University of Science
Journal of Physical Chemistry C | Year: 2011

Adsorption and separation of CO2/CH4 were examined on two kinds of amorphous silica molecular sieves, ASMS-3A and ASMS-5A, that are composed of spherical cavities arranged in a face-centered-cubic array and connected through narrow necks of molecular dimensions. For ASMS-3A, the exclusion of CH4 molecules due to their dimensions into the narrow necks and preferential adsorption of CO2 with the smaller kinetic diameter is observed at 283 K. In addition, the amount of CO2 adsorbed at 283 K does not decrease at all with surface hydration. All these results suggest that ASMS-3A is a promising candidate for the separation and purification of CO2 from various CO2/CH4 mixtures such as natural gas and landfill gas by a PSA process. © 2011 American Chemical Society.

Maeda Y.,Okayama University of Science
International Journal of Hematology | Year: 2013

In addition to reduced-intensity conditioning, which has expanded the eligibility for hematopoietic cell transplantation (HCT) to older patients, increased availability of alternative donors, including HLA-mismatched unrelated donors, has increased access to allogeneic HCT for more patients. However, acute graft-versus-host disease (GVHD) remains a lethal complication, even in HLA-matched donor-recipient pairs. The pathophysiology of GVHD depends on aspects of adaptive immunity and interactions between donor T-cells and host dendritic cells (DCs). Recent work has revealed that the role of other immune cells and endothelial cells and components of the innate immune response are also important. Tissue damage caused by the conditioning regimen leads to the release of exogenous and endogenous "danger signals". Exogenous danger signals called pathogen-associated molecular patterns and endogenous noninfectious molecules known as damage-associated molecular patterns (DAMPs) are responsible for initiating or amplifying acute GVHD by enhancing DC maturation and alloreactive T-cell responses. A significant association of innate immune receptor polymorphisms with outcomes, including GVHD severity, was observed in patients receiving allogeneic HCT. Understanding of the role of innate immunity in acute GVHD might offer new therapeutic approaches. © 2013 The Japanese Society of Hematology.

Toyota S.,Okayama University of Science
Chemical Reviews | Year: 2010

Rotational isomerism involving acetylene carbons has been studied by experimental and theoretical methods conventionally used for conformational analysis. The rotational barriers and populations of alkyne conformers are influenced by various factors, such as steric and electronic effects, as discussed in general kinetic and thermodynamic studies. Other intermolecular and intramolecular interactions, such as hydrogen bond, solvation, electronic states, state of sample, and external stimulus, are possible factors affecting the rotational isomerism. The presence of one electronegative or one electropositive substituent at the propargylic position results in small effects on the energy profile. The observed and calculated data suggested that the barrier heights were influenced by electronic effects, steric effects, weak interactions, and other factors, some of which were only recently revealed by modern techniques.

Hayashi K.-I.,Okayama University of Science
Plant and Cell Physiology | Year: 2012

IAA, a naturally occurring auxin, is a simple signaling molecule that regulates many diverse steps of plant development. Auxin essentially coordinates plant development through transcriptional regulation. Auxin binds to TIR1/AFB nuclear receptors, which are F-box subunits of the SCF ubiquitin ligase complex. The auxin signal is then modulated by the quantitative and qualitative responses of the Aux/IAA repressors and the auxin response factor (ARF) transcription factors. The specificity of the auxin-regulated gene expression profile is defined by several factors, such as the expression of these regulatory proteins, their post-transcriptional regulation, their stability and the affinity between these regulatory proteins. Auxin-binding protein 1 (ABP1) is a candidate protein for an auxin receptor that is implicated in non-transcriptional auxin signaling. ABP1 also affects TIR1/AFB-mediated auxin-responsive gene expression, implying that both the ABP1 and TIR1/AFB signaling machineries coordinately control auxin-mediated physiological events. Systematic approaches using the comprehensive mapping of the expression and interaction of signaling modules and computational modeling would be valuable for integrating our knowledge of auxin signals and responses. © 2012 The Author.

Wada J.,Okayama University of Science | Makino H.,Okayama University of Science
Clinical Science | Year: 2013

The most problematic issue in clinical nephrology is the relentless and progressive increase in patients with ESRD (end-stage renal disease) worldwide. The impact of diabetic nephropathy on the increasing population with CKD (chronic kidney disease) and ESRD is enormous. Three major pathways showing abnormality of intracellular metabolism have been identified in the development of diabetic nephropathy: (i) the activation of polyol and PKC (protein kinase C) pathways; (ii) the formation of advanced glycation end-products; and (iii) intraglomerular hypertension induced by glomerular hyperfiltration. Upstream of these three major pathways, hyperglycaemia is the major driving force of the progression to ESRD from diabetic nephropathy. Downstream of the three pathways, microinflammation and subsequent extracellular matrix expansion are common pathways for the progression of diabetic nephropathy. In recent years, many researchers have been convinced that the inflammation pathways play central roles in the progression of diabetic nephropathy, and the identification of new inflammatory molecules may link to the development of new therapeutic strategies. Various molecules related to the inflammation pathways in diabetic nephropathy include transcription factors, pro-inflammatory cytokines, chemokines, adhesion molecules, Toll-like receptors, adipokines and nuclear receptors, which are candidates for the new molecular targets for the treatment of diabetic nephropathy. Understanding of these molecular pathways of inflammation would translate into the development of anti-inflammation therapeutic strategies. © 2013 Biochemical Society.

To examine the origin of an ink-bottle-like structure in SBA-15 formed by carbon coating and the effects of pore corrugation on capillary condensation and evaporation of a vapor in the cylindrical pores, we measured the adsorption isotherms of nitrogen at 77 K on 10 kinds of SBA-15 samples before and after a carbon coating process by the exposure to acetylene at 1073 K, as well as desorption scanning curves and subloops on the untreated samples. These SBA-15 samples were synthesized under the different conditions of initial SiO 2/P123 ratio and hydrothermal treatment. SBA-15 with relatively large microporosity tends to form easily constrictions inside the main channels by the carbon coating. This strongly suggests that the rough pore walls of SBA-15 may induce the incomplete wetting of carbon layers on the pore walls to form the constrictions inside the cylindrical pores. A comparison of two subloops implies that the pores of SBA-15 synthesized with a SiO2/P123 ratio of 75 consist of an assembly of connecting domains of different diameters; that is, the pores are highly corrugated. For SBA-15 synthesized with a SiO 2/P123 ratio of 60, the amplitude of the pore corrugation is significantly decreased by the prolonged hydrothermal treatment at 373 K. On the other hand, for SBA-15 synthesized with a SiO2/P123 ratio of 45, the amplitude of the corrugation is negligibly small, although the cylindrical pores are interconnected through narrow necks with each other. It is found that the smaller the amplitude of the pore corrugation, the smaller the width of the hysteresis loop. © 2013 American Chemical Society.

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