Okayama Southern Institute of Health

Okayama-shi, Japan

Okayama Southern Institute of Health

Okayama-shi, Japan
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Miyatake N.,Kagawa University | Shikata K.,Okayama University of Science | Makino H.,Okayama University of Science | Numata T.,Okayama Southern Institute of Health
Internal Medicine | Year: 2010

Objective We investigated the link between renal function as evaluated by estimated glomerular filtration rate (eGFR) and pulse wave velocity (PWV) in Japanese without medications. Methods A total of 1,244 Japanese subjects, aged 20-79 years, were recruited in a cross-sectional clinical investigation study. They received no medications. eGFR was calculated using serum creatinine (Cr), age and sex. Peripheral arterial stiffness was evaluated by brachial-ankle PWV (baPWV). Results eGFR and baPWV were significantly correlated with age. eGFR was negatively correlated with baPWV (men: r=-0.308, p<0.0001, women: r=-0.293, p<0.0001). Twenty-six men (5.6%) and 35 women (4.5%) were diagnosed as reduced eGFR (eGFR <60 mL/min/1.73 m2). We compared clinical parameters between subjects with reduced eGFR (Group R) and without such reduction (Group N). baPWV in Group R was significantly higher than that in Group N even after adjusting for age. In women, systolic blood pressure in Group R was also significantly higher than that in Group N. Conclusion eGFR was closely associated with peripheral arterial stiffness in Japanese. © 2010 The Japanese Society of Internal Medicine.


Miyatake N.,Kagawa University | Shikata K.,Okayama University of Science | Makino H.,Okayama University of Science | Numata T.,Okayama Southern Institute of Health
Acta Medica Okayama | Year: 2010

The link between changes in a subject's metabolic syndrome components and her estimated glomerular filtration rate (eGFR) was evaluated in healthy Japanese women. We used data for 53 Japanese women (46.0 ± 10.9 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. There were no significant relationships between eGFR and clinical parameters at baseline. Subjects were given advice for dietary and lifestyle improvement. At the 1-year follow up, eGFR was significantly increased. In addition, changes in eGFR were weakly correlated with systolic blood pressure (r = -0.306, p = 0.0260). A decrease in systolic blood pressure may be associated with improving eGFR in Japanese women. © 2010 by Okayama University Medical School.


Miyatake N.,Kagawa University | Shikata K.,Okayama University of Science | Makino H.,Okayama University of Science | Numata T.,Okayama Southern Institute of Health
Acta Medica Okayama | Year: 2010

We investigated the link between renal function as evaluated by estimated glomerular filtration rate (eGFR) and metabolic syndrome in Japanese. A total of 11,711 Japanese subjects, aged 20-79 years, were recruited in a cross-sectional clinical investigation. From this group, we further investigated the data on 1,576 subjects. eGFR was calculated using serum creatinine (Cr), age and sex. The diagnosis of metabolic syndrome was based on the Japanese criteria. In the first analysis, 288 men (7.8%) and 498 women (6.2%) were diagnosed with reduced eGFR (<60ml/min). eGFR was not correlated with anthropometric, body composition parameters in either sex. In the second analysis, in subjects without medications, 132 men (20.8%) and 15 women (1.6%) were diagnosed with metabolic syndrome. eGFR was lower in men with abdominal obesity and in women with hypertension was than in those without. Among Japanese not taking medications, lower eGFR may be a characteristic of men with abdominal obesity and of women with hypertension. © 2010 by Okayama University Medical School.


Miyatake N.,Kagawa University | Wada J.,Okayama University of Science | Nakatsuka A.,Okayama University of Science | Sakano N.,Kagawa University | And 4 more authors.
Environmental Health and Preventive Medicine | Year: 2014

Aim: To investigate the link between serum vaspin levels and physical activity and/or physical fitness in Japanese. Methods: A total of 156 subjects (81 men and 75 women) was enrolled in this cross-sectional study. Serum vaspin levels, physical activity by uniaxial accelerometers, peak oxygen uptake, and metabolic risk parameters were evaluated. We also assessed anthropometric and body composition parameters. Results: Serum vaspin levels were over the level of 10 ng/mL in 15 subjects (9.6%: Vaspin High group). In Vaspin Low group (<5 ng/mL: 74 men and 67 women), serum vaspin levels were 0.12 ± 0.18 ng/mL in men and 0.39 ± 0.70 ng/mL in women. Peak oxygen uptake was significantly and positively correlated with serum vaspin levels even after adjusting for age, physical activity evaluated by Σ[metabolic equivalents x h per week (METs·h/w)], BMI, and other confounding factors in men. In turn, physical activity was significantly and positively correlated with serum vaspin levels even after adjusting for confounding factors in women. Conclusion: Serum vaspin levels were closely associated with physical fitness in men and physical activity in women independent of body composition in this Japanese cohort. © The Japanese Society for Hygiene 2014.


Miyatake N.,Kagawa University | Numata T.,Okayama Southern Institute of Health | Murakami H.,National Institute of Health and Nutrition | Kawakami R.,National Institute of Health and Nutrition | And 3 more authors.
Environmental Health and Preventive Medicine | Year: 2014

Objective: The aim of this study was to investigate the link between circulating adiponectin levels and peak oxygen uptake and/or physical activity in Japanese. Methods: A total of 528 subjects (188 men and 340 women) were enrolled in this cross-sectional study. Circulating adiponectin levels, physical activity measured by tri-axial accelerometers, peak oxygen uptake and metabolic risk parameters were evaluated. We also assessed anthropometric factors, blood pressure, blood examinations and energy intake. Results: Circulating adiponectin levels were 6.7 ± 3.0 μg/mL in men and 11.0 ± 4.9 μg/mL in women. Circulating adiponectin levels were positively correlated with physical fitness after adjusting for age, physical activity evaluated by ∑ [metabolic equivalents x h per week (METs h/w)], cigarette smoking habit and energy intake in both sexes. However, these associations were attenuated further after adjusting for body mass index including other confounding factors, especially in men. However, circulating adiponectin levels were not associated with physical activity in either sex. Conclusion: Circulating adiponectin levels were associated with peak oxygen uptake rather than physical activity. © 2014 The Japanese Society for Hygiene.


PubMed | Toyota Motor Corporation, Fukuoka City Medical Association Hospital, Okayama Southern Institute of Health, Japan National Cardiovascular Center Research Institute and 2 more.
Type: Controlled Clinical Trial | Journal: Obesity research & clinical practice | Year: 2014

Adequate goal-setting is important in health counselling and treatment for obesity and overweight. We tried to determine the minimum weight reduction required for improvement of obesity-related risk factors and conditions in obese and overweight Japanese people, using a nationwide intervention programme database.Japanese men and women (n=3480; mean agestandard deviation [SD], 48.35.9 years; mean body mass indexSD, 27.72.5kgm(-2)) with Obesity Disease or Metabolic Syndrome participated in a 6-month lifestyle modification programme (specific health guidance) and underwent follow-up for 6 months thereafter. The relationship between percent weight reduction and changes in 11 parameters of obesity-related diseases were examined.Significant weight reduction was observed 6 months after the beginning of the programme, and it was maintained for 1 year. Concomitant improvements in parameters for obesity-related diseases were also observed. One-third of the subjects reduced their body weight by 3%. In the group exhibiting 1% to <3% weight reduction, plasma triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), haemoglobin A1c (HbA1c), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and -glutamyl transpeptidase (-GTP) decreased significantly, and high-density lipoprotein cholesterol (HDL-C) increased significantly compared to the control group (1% weight change group). In addition to the improvements of these 7 parameters (out of 11), significant reductions in systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG) and uric acid (UA) (total 11 of 11 parameters) were observed in the group with 3% to <5% weight reduction. In the group with 5% weight reduction, the same 11 parameters also improved as those in the group with 3% to <5% weight reduction.The 6-month lifestyle modification programme induced significant weight reduction and significant improvement of parameters of obesity-related diseases. All the measured obesity-related parameters were significantly improved in groups with 3% to <5% and 5% weight reduction. Based on these findings, the minimum weight reduction required for improvement of obesity-related risk factors or conditions is 3% in obese and overweight (by WHO classification) Japanese people.


Higuchi C.,Okayama University of Science | Nakatsuka A.,Okayama University of Science | Eguchi J.,Okayama University of Science | Teshigawara S.,Okayama University of Science | And 9 more authors.
Metabolism: Clinical and Experimental | Year: 2015

Purpose The unique circulating microRNAs (miRNAs) observed in patients with type 2 diabetes (T2D) are candidates as new biomarkers and therapeutic targets. In order to identify circulating miRNAs relevant to the disease process in case of type 2 diabetes, we performed the Illumina sequencing of miRNAs derived from the serum, liver and epididymal white adipose tissue (WAT) of diet-induced obese male C57BL/6J mice. Basic Procedures We selected four miRNAs, miR-101, miR-335, miR-375, and miR-802, which are increased in the sera and tissues of obese mice, and measured the serum levels of miRNAs in T2D and subjects with normal glucose tolerance (NGT). Main Findings The serum concentrations of miRNAs, log10miR-101, log10miR-375, and log10miR-802, were significantly increased in the T2D patients compared with NGT subjects (1.41 ± 2.01 v.s. - 0.57 ± 1.05 (P = 1.36 × 10- 5), 0.20 ± 0.58 v.s. 0.038 ± 1.00 (P = 3.06 × 10- 6), and 2.45 ± 1.27 v.s. 0.97 ± 0.98 (P = 0.014), respectively). The log10miR-335 values did not demonstrate any significant differences between the T2D and NGT groups (- 1.08 ± 1.35 v.s. - 0.38 ± 1.21 (P = 0.25)). According to the stepwise regression analysis, the HbA1c was an independent predictor of miR-101. Regarding the serum miR-802 levels, eGFR, HbA1c and HDL-C values were identified as significant determinants. Principal Conclusions The present findings demonstrated that the circulating miR-101, miR-375 and miR-802 levels are significantly increased in T2D patients versus NGT subjects and they may become the new biomarkers for type 2 diabetes. © 2015 Elsevier Inc. All rights reserved.


PubMed | Okayama University of Science and Okayama Southern Institute of Health
Type: Journal Article | Journal: Metabolism: clinical and experimental | Year: 2015

The unique circulating microRNAs (miRNAs) observed in patients with type 2 diabetes (T2D) are candidates as new biomarkers and therapeutic targets. In order to identify circulating miRNAs relevant to the disease process in case of type 2 diabetes, we performed the Illumina sequencing of miRNAs derived from the serum, liver and epididymal white adipose tissue (WAT) of diet-induced obese male C57BL/6J mice.We selected four miRNAs, miR-101, miR-335, miR-375, and miR-802, which are increased in the sera and tissues of obese mice, and measured the serum levels of miRNAs in T2D and subjects with normal glucose tolerance (NGT).The serum concentrations of miRNAs, log(10)miR-101, log(10)miR-375, and log(10)miR-802, were significantly increased in the T2D patients compared with NGT subjects (1.412.01 v.s. -0.571.05 (P=1.3610(-5)), 0.200.58 v.s. 0.0381.00 (P=3.0610(-6)), and 2.451.27 v.s. 0.970.98 (P=0.014), respectively). The log(10)miR-335 values did not demonstrate any significant differences between the T2D and NGT groups (-1.081.35 v.s. -0.381.21 (P=0.25)). According to the stepwise regression analysis, the HbA1c was an independent predictor of miR-101. Regarding the serum miR-802 levels, eGFR, HbA1c and HDL-C values were identified as significant determinants.The present findings demonstrated that the circulating miR-101, miR-375 and miR-802 levels are significantly increased in T2D patients versus NGT subjects and they may become the new biomarkers for type 2 diabetes.


Cao Z.-B.,National Institute of Health and Nutrition | Cao Z.-B.,Waseda University | Miyatake N.,Okayama Southern Institute of Health | Higuchi M.,Waseda University | And 2 more authors.
European Journal of Applied Physiology | Year: 2010

The present study investigated the use of the accelerometer-determined physical activity (PA) variables as the objective PA variables for estimating V̇O2max in Japanese adult men. One hundred and twenty-seven Japanese adult men aged from 20 to 69 years were recruited as subjects of the present study. Maximal oxygen uptake (V̇O2max) was measured with a maximal incremental test on a bicycle ergometer. Daily step counts (SC) and the amount spent in moderate to vigorous PA (MVPA) and vigorous PA (VPA) were measured using accelerometer-based activity monitors worn at the waist for seven consecutive days. The non-exercise models were derived using hierarchical linear regression analysis, and cross-validated using two separate cross-validation procedures. SC, MVPA, and VPA were significantly related to V̇O2max (partial correlation coefficient r = 0.58, r = 0.42, and r = 0.51, respectively) after adjusting for age. Two models were developed by multiple regression to estimate V̇O2max using data of age, SC, VPA, and either BMI (the coefficient of determination (R2) = 0.71, standard error of estimate (SEE) = 4.2 ml kg-1 min-1), or waist circumference (R2 = 0.74, SEE = 3.9 ml kg-1 min -1). All regression models demonstrated a high level of cross-validity supported by the minor shrinkage of R2 and increment of SEE in the PRESS procedure, and by small constant errors for subgroups of age, SC, and V̇O2max: This study demonstrated that combining SC with VPA, but not with MVPA, was useful in predicting V̇O2max variance and improved the ability of the regression models to accurately predict V̇O2max. © Springer-Verlag 2010.


PubMed | Okayama Southern Institute of Health
Type: Journal Article | Journal: Environmental health and preventive medicine | Year: 2015

To investigate the link between cigarette smoking and one leg with eyes closed balance in Japanese men.We used data from 4224 Japanese men, aged 43.313.9years, in this cross-sectional study. Balance, such as one leg with eyes closed balance was measured. In addition, cigarette smoking habits were obtained by well-trained medical staff. The effect of cigarette smoking on one leg with eye closed balance was evaluated.A total of 1613 men (38.2%) had smoking habit and 1471 men (34.8%) regularly exercised. Age-related changes in one leg with eyes closed balance were noted. One leg with eyes closed balance in subjects with cigarette smoking (30.931.8s) was significantly lower than those in subjects without cigarette smoking (32.433.5s) even after adjusting for confounding factors i.e. age, body weight and exercise habits.Cigarette smoking might be associated with one leg with eyes closed balance in Japanese men.

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