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Oita, Japan

Oita University is a national university in Ōita, Ōita, Japan. The precursor of the school was founded in 1921 and was chartered as a university in 1949. Wikipedia.

Honda K.,Oita University
World journal of gastroenterology : WJG | Year: 2012

A 69-year-old man was admitted to our hospital in October 2003, for further examination of two liver tumors. He was diagnosed with hepatocellular carcinoma (HCC) arising from decompensated hepatitis B virus (HBV)-related cirrhosis. Long-term lamivudine administration improved liver function dramatically despite repeated treatment for HCC. His Child-Pugh score was 9 points at start of lamivudine treatment, improving to 5 points after 1 year. His indocyanine green at 15 min after injection test score was 48% before lamivudine treatment, improving to 22% after 2 years and to 5% after 4 years. Radiofrequency ablation controlled the HCC foci and maintained his liver function. In April 2009, abdominal computed tomography revealed a tumor thrombus in the right portal vein. Since his indocyanine green test results had improved to less than 10%, we performed a right hepatectomy, which was successful. To our knowledge, there have been no documented reports of patients undergoing successful right hepatectomy for HCC arising from decompensated cirrhosis. The findings observed in our patient indicate the importance of nucleoside analogs for treating HBV-related HCC. Source

Ji R.-C.,Oita University
Cellular and Molecular Life Sciences | Year: 2012

The lymphatic system provides important functions for tissue fluid homeostasis and immune response. Lymphangiogenesis, the formation of new lymphatics, comprises a series of complex cellular events in vitro or in vivo, e.g., proliferation, differentiation, and sprouting. Recent evidence has implied that macrophages act as a direct structural contributor to lymphatic endothelial walls or secret VEGF-C/-D and VEGF-A to initiate lymphangiogenesis in inflamed or tumor tissues. Bone marrow-derived macrophages are versatile cells that express different functional programs in response to exposure to microenvironmental signals, and can be identified by specific expression of a number of proteins, F4/80, CD11b, and CD68. Several causative factors, e.g., NF-κB, IL-1β, TNF-α, SDF-1, M-CSF, especially TonEBP/ VEGF-C signaling, may be actively involved in macrophage-induced lymphangiogenesis. Alteration of macrophage phenotype and function has a profound effect on the development and progression of inflammation and malignancy, and macrophage depletion for controlling lymphangiogenesis may provide a novel approach for prevention and treatment of lymphaticassociated diseases. © 2011 Springer Basel AG. Source

Amao Y.,Oita University
ChemCatChem | Year: 2011

Models of photosynthesis mimetic systems, the so-called artificial photosynthesis systems, have been investigated since the 1970s for the purpose of tapping solar energy. With the deterioration of the global environment in the 21st century, attributed to global warming and greenhouse gas emissions, it has become imperative to identify new fuel sources such as solar energy to replace fossil fuels. Among the new fuel production systems, those involving the use of solar energy have attracted attention; examples are systems that produce hydrogen through water photolysis and those that produce methanol by CO 2 reduction with the aid of an artificial photosynthesis system. As hydrogen and methanol are low-carbon fuels (the emission of CO 2 from the combustion of these fuels is low), they are considered to be alternatives to fossil resources. In this review, solar fuel production systems consisting of an artificial photosynthesis system, a catalyst, and an enzyme are discussed. These systems are expected to help in reducing CO 2 and to promote the use of low-carbon fuels in the future. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

Yamaoka Y.,Oita University
Nature Reviews Gastroenterology and Hepatology | Year: 2010

Helicobacter pylori plays an essential role in the development of various gastroduodenal diseases; however, only a small proportion of people infected with H. pylori develop these diseases. Some populations that have a high prevalence of H. pylori infection also have a high incidence of gastric cancer (for example, in East Asia), whereas others do not (for example, in Africa and South Asia). Even within East Asia, the incidence of gastric cancer varies (decreasing in the south). H. pylori is a highly heterogeneous bacterium and its virulence varies geographically. Geographic differences in the incidence of gastric cancer can be explained, at least in part, by the presence of different types of H. pylori virulence factor, especially CagA, VacA and OipA. However, it is still unclear why the pathogenicity of H. pylori increased as it migrated from Africa to East Asia during the course of evolution. H. pylori infection is also thought to be involved in the development of duodenal ulcer, which is at the opposite end of the disease spectrum to gastric cancer. This discrepancy can be explained in part by the presence of H. pylori virulence factor DupA. Despite advances in our understanding of the development of H. pylori-related diseases, further work is required to clarify the roles of H. pylori virulence factors. © 2010 Macmillan Publishers Limited. All rights reserved. Source

Hirano T.,Oita University
Contributions to Nephrology | Year: 2013

Thrombolytic therapy using recombinant tissue plasminogen activator (rt-PA) is established as an effective treatment for patients with acute ischemic stroke. No distinction to the presence of chronic kidney disease (CKD) was made in previous clinical trials. In this chapter, three clinical studies that investigated renal dysfunction on the effect of rt-PA were reviewed and a meta-analysis was performed. In total, 344 patients with CKD and 504 patients without were treated within 3 h of symptom onset. Patients with CKD showed decreased odds of being alive and independent compared to patients with normal renal function (OR 0.60, 95% CI 0.45-0.81). Symptomatic intracranial hemorrhage occurred more in patients with CKD than without (OR 3.38, 95% CI 1.60-7.15). Risk of fatal outcome was also significantly higher in patients with CKD (OR 3.15, 95% CI 1.82-5.45). Copyright © 2013 S. Karger AG, Basel. Source

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