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Maple Park, IL, United States

OHMX Corporation | Date: 2014-04-16

The invention relates to novel compositions and methods for the detection of analytes using the nuclear reorganization energy, , of an electron transfer process.

OHMX Corporation | Date: 2015-09-23

Methods for predicting the outcome of and monitoring prostate cancer patients using prostate specific antigen (PSA) proteolytic activity (PPA) in combination with other molecular biomarkers or other parameters are described. Methods of determining sets of parameters for use in predicting the outcome of and monitoring of prostate cancer patients are also described.

Ohmx Corporation | Date: 2015-01-09

The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes.

The disclosure relates to novel methods for performing a solution based assay reaction with an electroactive active moiety (EAM) that subsequently forms a self-assembled monolayer (SAM) utilizing the advantages of faster solution reaction kinetics, SAM protected electrode and surface based electrochemistry for electronic measurement.

Methods for the electrochemical detection of target analytes using a porous substrate and related systems are provided. In some embodiments, an electrochemical assay comprises determining the presence, absence, and/or concentration of one or more target analyte based on the electrical potential of an electroactive moiety (EAM) comprising a self-immolative moiety (SIM). In some embodiments, at least a portion of the electrochemical assay may occur within, on, and/or near a porous substrate. In some such embodiments, one or more component of the electrochemical assay (e.g., capture ligand, enzyme) may be immobilized within and/or on the porous substrate. In some embodiments, the immobilization of one or more assay components within and/or on the porous substrate may allow for the detection of multiple target analytes in a single sample as well as enhance assay performance.

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