Ohmx Corporation

Maple Park, IL, United States

Ohmx Corporation

Maple Park, IL, United States
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The disclosure relates to novel methods for performing a solution based assay reaction with an electroactive active moiety (EAM) that subsequently forms a self-assembled monolayer (SAM) utilizing the advantages of faster solution reaction kinetics, SAM protected electrode and surface based electrochemistry for electronic measurement.


Patent
Ohmx Corporation | Date: 2017-03-08

In one aspect, a method for detection of a target in a sample based on the change of electrochemical cyclic voltammetry peak profile is provided. The method may involve at least two or more electroactive moieties (EAMs) comprising a transitional metal complex and an anchor group. Said transitional metal complex may be capable of reversibly or semi-reversibly transferring one or more electrons. Said anchor group may allow said EAMs to covalently attach to a solid support, forming a self-assembled monolayer (SAM) on the surface. At least one EAM may further comprises a capture ligand that can be recognized and bound by a target or a surrogate target. When a sample is introduced to an EAM, the interaction between said capture ligand and said target or surrogate target may lead to change of the properties of the SAM containing all EAMs involved. Said change can be detected by an electrochemical detection system.


Methods for the electrochemical detection of target analytes using a porous substrate and related systems are provided. In some embodiments, an electrochemical assay comprises determining the presence, absence, and/or concentration of one or more target analyte based on the electrical potential of an electroactive moiety (EAM) comprising a self-immolative moiety (SIM). In some embodiments, at least a portion of the electrochemical assay may occur within, on, and/or near a porous substrate. In some such embodiments, one or more component of the electrochemical assay (e.g., capture ligand, enzyme) may be immobilized within and/or on the porous substrate. In some embodiments, the immobilization of one or more assay components within and/or on the porous substrate may allow for the detection of multiple target analytes in a single sample as well as enhance assay performance.


Patent
OHMX Corporation | Date: 2015-09-23

Methods for predicting the outcome of and monitoring prostate cancer patients using prostate specific antigen (PSA) proteolytic activity (PPA) in combination with other molecular biomarkers or other parameters are described. Methods of determining sets of parameters for use in predicting the outcome of and monitoring of prostate cancer patients are also described.


Patent
OHMX Corporation | Date: 2015-12-18

The disclosure also relates to novel methods for detection of biological targets using amplification steps in conjunction with conversion of functional groups attached to a transitional metal complex, resulting in quantifiable electrochemical signal at two unique potentials, E^(o)_(1 )and E^(o)_(2).


Patent
Ohmx Corporation | Date: 2015-01-09

The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes.


Patent
OHMX Corporation | Date: 2015-04-29

In one aspect, a method for detection of a target in a sample based on the change of electrochemical cyclic voltammetry peak profile is provided. The method may involve at least two or more electroactive moieties (EAMs) comprising a transitional metal complex and an anchor group. Said transitional metal complex may be capable of reversibly or semi-reversibly transferring one or more electrons. Said anchor group may allow said EAMs to covalently attach to a solid support, forming a self-assembled monolayer (SAM) on the surface. At least one EAM may further comprises a capture ligand that can be recognized and bound by a target or a surrogate target. When a sample is introduced to an EAM, the interaction between said capture ligand and said target or surrogate target may lead to change of the properties of the SAM containing all EAMs involved. Said change can be detected by an electrochemical detection system.


The disclosure relates to novel methods for performing a solution based assay reaction with an electroactive active moiety (EAM) that subsequently forms a self-assembled monolayer (SAM) utilizing the advantages of faster solution reaction kinetics, SAM protected electrode and surface based electrochemistry for electronic measurement.


Patent
OHMX Corporation | Date: 2014-05-19

The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, , of an electron transfer process.


Patent
OHMX Corporation | Date: 2015-12-18

Competitive assays are provided for the detection and quantification of a target analyte utilizing a modified electro-active moiety and an enzyme, in which the target analyte and a target analog moiety are substrates. This method may be used to detect and/or quantify many classes of biological molecules and has a number of applications, e.g., in vitro diagnostic assays and devices.

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