Ohkawara Kakohki Co.

Tsuzuki ku, Japan

Ohkawara Kakohki Co.

Tsuzuki ku, Japan

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Onoue S.,University of Shizuoka | Uchida A.,University of Shizuoka | Nakamura T.,University of Shizuoka | Kuriyama K.,University of Shizuoka | And 6 more authors.
PharmaNutrition | Year: 2015

The major purpose of the present study was to clarify the physicochemical and nutraceutical properties of self-nanoemulsifying particles of coenzyme Q10 (CoQ10/SNEP). Nanoemulsion preconcentrate, containing CoQ10, medium-chain triglyceride, sucrose ester of fatty acid, and hydroxypropyl cellulose, was spray-dried to produce the CoQ10/SNEP. The CoQ10/SNEP was stored at 40 °C with or without 75% relative humidity (RH) for 4 weeks, and its physicochemical properties were characterized in terms of appearance, crystallinity, thermal behavior, dissolution, and self-nanoemulsifying potency. The hepatoprotective effects of CoQ10 and the CoQ10/SNEP were also assessed in a rat model of acute liver injury. Under accelerated conditions (40 °C/75% RH), the CoQ10/SNEP was found to be physicochemically unstable, as evidenced by partial deliquescence, slight degradation, reduced dissolution rate, and larger particle size of resultant micelles. In contrast, there appeared to be no significant transition in physicochemical properties of the CoQ10/SNEP after 4 weeks of storage at 40 °C. The outcomes from stability testing suggested that moisture protection would be needed for long-term storage of the CoQ10/SNEP. In a rat model of acute liver injury, pretreatment with CoQ10/SNEP (100 mg CoQ10/kg, twice) resulted in marked attenuation of hepatic damage as evidenced by decreases of alanine aminotransferase and aspartate aminotransferase, surrogate biomarkers for hepatic injury, by 96% and 82%, respectively, although crystalline CoQ10 was less effective. From these findings, the self-nanoemulsifying approach might be efficacious for improving the nutraceutical values of CoQ10. © 2015 Elsevier B.V.


Onoue S.,University of Shizuoka | Uchida A.,University of Shizuoka | Nakamura T.,University of Shizuoka | Kuriyama K.,University of Shizuoka | And 6 more authors.
PharmaNutrition | Year: 2015

The major purpose of the present study was to clarify the physicochemical and nutraceutical properties of self-nanoemulsifying particles of coenzyme Q10 (CoQ10/SNEP). Nanoemulsion preconcentrate, containing CoQ10, medium-chain triglyceride, sucrose ester of fatty acid, and hydroxypropyl cellulose, was spray-dried to produce the CoQ10/SNEP. The CoQ10/SNEP was stored at 40°C with or without 75% relative humidity (RH) for 4 weeks, and its physicochemical properties were characterized in terms of appearance, crystallinity, thermal behavior, dissolution, and self-nanoemulsifying potency. The hepatoprotective effects of CoQ10 and the CoQ10/SNEP were also assessed in a rat model of acute liver injury. Under accelerated conditions (40°C/75% RH), the CoQ10/SNEP was found to be physicochemically unstable, as evidenced by partial deliquescence, slight degradation, reduced dissolution rate, and larger particle size of resultant micelles. In contrast, there appeared to be no significant transition in physicochemical properties of the CoQ10/SNEP after 4 weeks of storage at 40°C. The outcomes from stability testing suggested that moisture protection would be needed for long-term storage of the CoQ10/SNEP. In a rat model of acute liver injury, pretreatment with CoQ10/SNEP (100mg CoQ10/kg, twice) resulted in marked attenuation of hepatic damage as evidenced by decreases of alanine aminotransferase and aspartate aminotransferase, surrogate biomarkers for hepatic injury, by 96% and 82%, respectively, although crystalline CoQ10 was less effective. From these findings, the self-nanoemulsifying approach might be efficacious for improving the nutraceutical values of CoQ10. © 2015 Elsevier B.V.


Patent
Ohkawara Kakohki Co. and University of Tokyo | Date: 2015-12-04

Embodiments of the invention provide a seawater desalination device, including a steam re-compressor configured to pressurize steam by pressurizing a steam; a first heat exchanger configured to exchange an amount of sensible heat of seawater to be desalinated with an amount of liquid sensible heat after pressurized steam is condensed, and an amount of sensible heat of a concentrated liquid after seawater is concentrated; a second heat exchanger configured to exchange an amount of heat of pressurized steam, an amount of latent heat of vaporization of seawater, and an amount of sensible heat when seawater is evaporated, and configured to concentrate seawater; a seawater supply means; a steam supply means; a first discharge means; a second discharge means; and a water-droplet separation means.


Patent
Ohkawara Kakohki Co. and University of Tokyo | Date: 2016-04-13

Provided are a seawater desalination device and a seawater desalination method based on an evaporation method, in which an self-heat recuperation process is used to reduce an amount of necessary energy in half or less, compared with the conventional multi-stage flash method. Specifically, using a three-phase fluidized bed allows a highly heat-efficient operation, while preventing scaling to a heat-transmitting surface, even in a high salinity concentration. This seawater desalination device (1) includes a steam re-compressor (3) capable of pressurizing steam by pressurizing a steam; a first heat exchanger (5) capable of exchanging amount of sensible heat of seawater to be desalinated with amount of liquid sensible heat after pressurized steam is condensed, and amount of sensible heat of a concentrated liquid after seawater is concentrated; a second heat exchanger (7) capable of exchanging amount of heat of pressurized steam, amount of latent heat of vaporization of seawater, and amount of sensible heat when seawater is evaporated, as well as capable of concentrating seawater; a seawater supply means (17); a steam supply means (13); a first discharge means (21); a second discharge means (23); and a water-droplet separation means (25).

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