Ohkawara Kakohki Co.

Tsuzuki ku, Japan

Ohkawara Kakohki Co.

Tsuzuki ku, Japan
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Onoue S.,University of Shizuoka | Uchida A.,University of Shizuoka | Kuriyama K.,University of Shizuoka | Nakamura T.,University of Shizuoka | And 7 more authors.
European Journal of Pharmaceutical Sciences | Year: 2012

The present study was undertaken to develop a solid self-emulsifying drug delivery system of coenzyme Q 10 (CoQ 10/s-SEDDS) with high photostability and oral bioavailability. The CoQ 10/s-SEDDS was prepared by spray-drying an emulsion preconcentrate containing CoQ 10, medium-chain triglyceride, sucrose ester of fatty acid, and hydroxypropyl cellulose, and its physicochemical, photochemical, and pharmacokinetic properties were evaluated. The CoQ 10/s-SEDDS powder with a diameter of ca. 15 μm was obtained by spray-drying, in which the CoQ 10 was mostly amorphized. The CoQ 10/s-SEDDS exhibited immediate self-emulsification when introduced to aqueous media under gentle agitation, forming uniform fine droplets with a mean diameter of ca. 280 nm. There was marked generation of reactive oxygen species, in particular superoxide, from CoQ 10 exposed to simulated sunlight (250 W/m 2), suggesting potent photoreactivity. Nano-emulsified solution of CoQ 10 under light exposure underwent photodegradation with 22-fold higher degradation kinetics than crystalline CoQ 10, although the CoQ 10/s- SEDDS was less photoreactive. After the oral administration of CoQ 10/s-SEDDS (100 mg-CoQ 10/kg) in rats, enhanced exposure of CoQ 10 was observed with increases in both C max and AUC of ca. 5-fold in comparison with those of orally administered crystalline CoQ 10. From the improved physicochemical and pharmacokinetic data, the s-SEDDS approach upon spray-drying might be a suitable dosage option for enhancing nutraceutical and pharmaceutical values of CoQ 10. © 2012 Elsevier B.V. All rights reserved.


Ozeki T.,Nagoya City University | Akiyama Y.,Tokyo University of Pharmacy and Life Science | Takahashi N.,Tokyo University of Pharmacy and Life Science | Tagami T.,Nagoya City University | And 3 more authors.
Biological and Pharmaceutical Bulletin | Year: 2012

Production of drug nanoparticles is an effective strategy to enhance solubility and oral absorption of water-insoluble drugs. The handling of drug nanoparticles has been an important issue in drug formulation because nanoparticles easily aggregate each other and redispersion of these particles is very difficult. In the present study, we developed a unique two-solution mixing type spray nozzle that can prepare drug nanoparticles in microparticles in one step without any common solvent and surfactant, and then, the prepared formulation were evaluated. Ethylcellulose (EC) and mannitol (MAN) were used as a model polymer of water-insoluble compound and a water-soluble carrier, respectively. We characterized the EC/MAN microparticles produced by the novel spray nozzle when customizing the nozzle parts to mix EC and MAN solution. Relatively smaller EC nanoparticles (<110nm) in MAN microparticles (approximately 3μm) were obtained by changing the customizable parts in the nozzle. In addition, the core of EC nanoparticles (<50nm) was also observed by atomic force microscopy. We also found that the mixing time in the nozzle parts affected the size and the standard deviation of EC nanoparticles. These results suggest that the size of EC nanoparticles in MAN microparticles is controllable by using this unique nozzle. After all, we could prepare MAN microparticles containing EC nanoparticles in one step by using the novel nozzle. The drug/MAN microparticles formulation produced by the nozzle may be useful for the handling of drug nanoparticles. © 2012 The Pharmaceutical Society of Japan.


Onoue S.,University of Shizuoka | Uchida A.,University of Shizuoka | Nakamura T.,University of Shizuoka | Kuriyama K.,University of Shizuoka | And 6 more authors.
PharmaNutrition | Year: 2015

The major purpose of the present study was to clarify the physicochemical and nutraceutical properties of self-nanoemulsifying particles of coenzyme Q10 (CoQ10/SNEP). Nanoemulsion preconcentrate, containing CoQ10, medium-chain triglyceride, sucrose ester of fatty acid, and hydroxypropyl cellulose, was spray-dried to produce the CoQ10/SNEP. The CoQ10/SNEP was stored at 40 °C with or without 75% relative humidity (RH) for 4 weeks, and its physicochemical properties were characterized in terms of appearance, crystallinity, thermal behavior, dissolution, and self-nanoemulsifying potency. The hepatoprotective effects of CoQ10 and the CoQ10/SNEP were also assessed in a rat model of acute liver injury. Under accelerated conditions (40 °C/75% RH), the CoQ10/SNEP was found to be physicochemically unstable, as evidenced by partial deliquescence, slight degradation, reduced dissolution rate, and larger particle size of resultant micelles. In contrast, there appeared to be no significant transition in physicochemical properties of the CoQ10/SNEP after 4 weeks of storage at 40 °C. The outcomes from stability testing suggested that moisture protection would be needed for long-term storage of the CoQ10/SNEP. In a rat model of acute liver injury, pretreatment with CoQ10/SNEP (100 mg CoQ10/kg, twice) resulted in marked attenuation of hepatic damage as evidenced by decreases of alanine aminotransferase and aspartate aminotransferase, surrogate biomarkers for hepatic injury, by 96% and 82%, respectively, although crystalline CoQ10 was less effective. From these findings, the self-nanoemulsifying approach might be efficacious for improving the nutraceutical values of CoQ10. © 2015 Elsevier B.V.


Onoue S.,University of Shizuoka | Uchida A.,University of Shizuoka | Nakamura T.,University of Shizuoka | Kuriyama K.,University of Shizuoka | And 6 more authors.
PharmaNutrition | Year: 2015

The major purpose of the present study was to clarify the physicochemical and nutraceutical properties of self-nanoemulsifying particles of coenzyme Q10 (CoQ10/SNEP). Nanoemulsion preconcentrate, containing CoQ10, medium-chain triglyceride, sucrose ester of fatty acid, and hydroxypropyl cellulose, was spray-dried to produce the CoQ10/SNEP. The CoQ10/SNEP was stored at 40°C with or without 75% relative humidity (RH) for 4 weeks, and its physicochemical properties were characterized in terms of appearance, crystallinity, thermal behavior, dissolution, and self-nanoemulsifying potency. The hepatoprotective effects of CoQ10 and the CoQ10/SNEP were also assessed in a rat model of acute liver injury. Under accelerated conditions (40°C/75% RH), the CoQ10/SNEP was found to be physicochemically unstable, as evidenced by partial deliquescence, slight degradation, reduced dissolution rate, and larger particle size of resultant micelles. In contrast, there appeared to be no significant transition in physicochemical properties of the CoQ10/SNEP after 4 weeks of storage at 40°C. The outcomes from stability testing suggested that moisture protection would be needed for long-term storage of the CoQ10/SNEP. In a rat model of acute liver injury, pretreatment with CoQ10/SNEP (100mg CoQ10/kg, twice) resulted in marked attenuation of hepatic damage as evidenced by decreases of alanine aminotransferase and aspartate aminotransferase, surrogate biomarkers for hepatic injury, by 96% and 82%, respectively, although crystalline CoQ10 was less effective. From these findings, the self-nanoemulsifying approach might be efficacious for improving the nutraceutical values of CoQ10. © 2015 Elsevier B.V.


Patent
Ohkawara Kakohki Co. and University of Tokyo | Date: 2015-12-04

Embodiments of the invention provide a seawater desalination device, including a steam re-compressor configured to pressurize steam by pressurizing a steam; a first heat exchanger configured to exchange an amount of sensible heat of seawater to be desalinated with an amount of liquid sensible heat after pressurized steam is condensed, and an amount of sensible heat of a concentrated liquid after seawater is concentrated; a second heat exchanger configured to exchange an amount of heat of pressurized steam, an amount of latent heat of vaporization of seawater, and an amount of sensible heat when seawater is evaporated, and configured to concentrate seawater; a seawater supply means; a steam supply means; a first discharge means; a second discharge means; and a water-droplet separation means.


Patent
Ohkawara Kakohki Co. and University of Tokyo | Date: 2016-04-13

Provided are a seawater desalination device and a seawater desalination method based on an evaporation method, in which an self-heat recuperation process is used to reduce an amount of necessary energy in half or less, compared with the conventional multi-stage flash method. Specifically, using a three-phase fluidized bed allows a highly heat-efficient operation, while preventing scaling to a heat-transmitting surface, even in a high salinity concentration. This seawater desalination device (1) includes a steam re-compressor (3) capable of pressurizing steam by pressurizing a steam; a first heat exchanger (5) capable of exchanging amount of sensible heat of seawater to be desalinated with amount of liquid sensible heat after pressurized steam is condensed, and amount of sensible heat of a concentrated liquid after seawater is concentrated; a second heat exchanger (7) capable of exchanging amount of heat of pressurized steam, amount of latent heat of vaporization of seawater, and amount of sensible heat when seawater is evaporated, as well as capable of concentrating seawater; a seawater supply means (17); a steam supply means (13); a first discharge means (21); a second discharge means (23); and a water-droplet separation means (25).

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