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Chūō-ku, Japan

Katayama H.,Ogachi Chuo Hospital | Mituzuka K.,Ogachi Chuo Hospital | Kawasaki Y.,Ogachi Chuo Hospital | Kato S.,Ogachi Chuo Hospital
Acta Urologica Japonica

A 64-year-old man was referred to our hospital with chief complaints of gross hematuria and pollakisuria. Cystoscopic examination showed non-papillary broad basis tumor on the left lateral wall involving the left ureteral orifice. Computed tomography (CT) and magnetic resonance imaging revealed left hydronephrosis and urinary bladder tumor which extended outside of the bladder wall. Transurethral biopsy showed grade 3 urothelial carcinoma with glandular differentiation including signet ring cells. Radical cystectomy, left nephrureterectomy and right ureterocutaneostomy were performed. Pathological examination showed urothelial carcinoma; pT3aN0. Lymph node metastasis occurred five months later. Three courses of M-VAC chemotherapy (methotrexate, vinblastine, adriamycin, cisplatin) were done with litde effectiveness. Sixteen months after the operation, he complained of anorexia and tenesmus, and CT showed annular thickening of the rectal wall. A fecal diversion was performed, but he died two months later. Source

Sasaki Y.,Ogachi Chuo Hospital | Minamiya Y.,Akita University | Okuyama M.,Ogachi Chuo Hospital | Hibino M.,Ogachi Chuo Hospital | And 4 more authors.
Japanese Journal of Cancer and Chemotherapy

The patient was a 67-year-old female with left lung adenocarcinoma T2N2M1 (brain). She received systemic chemotherapy (cisplatin/docetaxel) and stereotactic radiosurgery. She showed a partial response and PET-CT evidenced no new metastasis. So she underwent left pneumonectomy (LtUt S6S8, adenocarcinoma mixed type pT2pN0). One month later, a small nodule appeared on the dorsal surface of her left hand. Excisional biopsy showed adenocarcinoma metastasis of lung cancer. Soon afterward, multiple skin nodules appeared and were diagnosed multiple skin metastases. Erlotinib was administered. After two weeks, skin metastases were reduced significantly, and she was treated with erlotinib on an outpatient basis for 5 months. This is, to our knowledge, the first case in which skin metastases of lung cancer responded to erlotinib. Our experience suggests erlotinib administration at an early treatment has fewer side effects in therapy for metastatic lung cancer. Source

Sasaki Y.,Ogachi Chuo Hospital | Okuyama M.,Ogachi Chuo Hospital | Hibino M.,Ogachi Chuo Hospital | Tenma K.,Ogachi Chuo Hospital | Nakamura M.,Ogachi Chuo Hospital
Japanese Journal of Cancer and Chemotherapy

We report an 84-year-old woman with an ulcerated tumor of her right breast. The histological examination showed invasive ductal carcinoma, ER (allred-score 8), PgR (allred-score 0), and HER2 (0). Computed tomography and bone scintigraphy showed no distant metastases. She was diagnosed with right locally advanced breast cancer (cT4bN2aM0, stage III B) and received hormone therapy with letrozole. One year after, the carcinoma was reduced in size and the skin ulcer had disappeared. Two years later, the carcinoma had grown back slightly, but the skin ulcer was still undetectable. Hormone therapy alone was considered useful for treatment of elderly locally advanced breast cancer patients. Source

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