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Patent
Stanford University and Office of Technology Transfer | Date: 2015-04-24

Novel human interleukin-2 (IL-2) muteins or variants thereof are provided. In particular, provided are IL-2 muteins that have an increased binding capacity for IL-2RP receptor and a decreased binding capacity for IL-2R_(c )receptor, as compared to wild-type IL-2. Such IL-2 muteins are useful, for example, as IL-2 partial agonist and antagonists in applications where reduction or inhibition of one or more IL-2 and/or IL-15 functions is useful (e.g., in the treatment of graft versus host disease (GVHD) and adult T cell leukemia). Also provided are nucleic acids encoding such IL-2 muteins, methods of making such IL-2 muteins, pharmaceutical compositions that include such IL-2 muteins and methods of treatment using such pharmaceutical compositions.


A radiation sensor including a scintillation layer configured to emit photons upon interaction with ionizing radiation and a photodetector including in order a first electrode, a photosensitive layer, and a photon-transmissive second electrode disposed in proximity to the scintillation layer. The photosensitive layer is configured to generate electron-hole pairs upon interaction with a part of the photons. The radiation sensor includes pixel circuitry electrically connected to the first electrode and configured to measure an imaging signal indicative of the electron-hole pairs generated in the photosensitive layer and a planarization layer disposed on the pixel circuitry between the first electrode and the pixel circuitry such that the first electrode is above a plane including the pixel circuitry. A surface of at least one of the first electrode and the second electrode at least partially overlaps the pixel circuitry and has a surface inflection above features of the pixel circuitry. The surface inflection has a radius of curvature greater than one half micron.


Patent
Office of Technology Transfer | Date: 2015-05-07

A novel MRI-compatible amplifier design uses positive feedback from a low-noise Field-Effect Transistor to amplify the signal current within a resonant NMR coil. The amplified signal current in this low-power circuit produces RF flux can be coupled out to receiving loops positioned externally without significant loss in sensitivity. In other aspects, the amplifier may be remotely powered by external resonant loops, a small non-magnetic battery, or optical power, such that the NMR coil can be positioned during highly invasive procedures such as for surgical resection of tumors in deep-lying tissues to develop high-resolution images.


Patent
Wayne State University, Semmelweis University, Office of Technology Transfer and Genesis Theranostix Korlatolt Felelossegu Tarsasag | Date: 2017-06-21

Disclosed are specific biomarkers that allow for early testing of preeclampsia/HELLP syndrome. Thus, a method is provided predicting preeclampsia in a pregnant woman. Also disclosed is a kit comprising means for assaying a sample from a pregnant woman for the concentrations of the specific biomarkers.


Patent
Office of Technology Transfer | Date: 2013-01-22

An energy-efficient CAM architecture provides increased speed of searching, reduced power consumption, or a tuned combination of increased speed of searching and reduced power consumption. The CAM comprises a plurality of CAM banks, a plurality of Bloom filters, each Bloom filter associated with a content addressable memory bank, each Bloom filter recording elements inserted into an associated content addressable memory bank, wherein the size of each Bloom filter is configured to reduce energy or power consumption of the content addressable memory apparatus. The size of each Bloom filter may be configured to reduce energy or power consumption of the content addressable memory apparatus.


Patent
Galiana Technology, Inc. and Office of Technology Transfer | Date: 2015-08-24

An intracellular monitoring device (IMD) that fits completely inside a living cell, and causes no significant impairment, to a cells normal biological processes. The IMD monitors a cell for its level of a biological substance (e.g., calcium ion concentration) of interest. If the biological substance reaches or exceeds a threshold, the IMD transmits an electromagnetic signal, received by an antenna outside the cell. Each IMD has its electromagnetic signal encoded with a unique frequency. Detection of the frequency components, in the signals received by an antenna, permits identification of the source IMDs. A high calcium ion concentration is indicative of a strongly-activated cerebral cortex neuron. Brain tissue is relatively transparent to near infrared, making it a good frequency band, for the electromagnetic signals from neuron-monitoring IMDs. The near infrared of each IMD can be produced by quantum dots, powered by bioelectric catalysis triggered by high calcium ion concentration.


Patent
Office of Technology Transfer | Date: 2016-03-15

Systems are configured to detect advanced fields, and are therefore able to provide instantaneous communications, radar detection, and remote telemetry. Receiving stations in communications systems and some telemetry systems communicate by modulating a variable termination resistor across the receivers input terminals. Radar systems and some telemetry systems are sensitive to differential absorption at the targets.


Patent
Office of Technology Transfer | Date: 2014-06-19

A bore covering for sealing an MRI scanner bore to create a controlled environment within the MRI scanner bore is disclosed. The bore coverings used with climate control devices may create an incubator-like environment to allow for improved preparation, control, and imaging of infants. A system and kit including one or more bore coverings, and a method of using the bore coverings to create a controlled environment within the MRI scanner bore are also described.


Patent
General Electric and Office of Technology Transfer | Date: 2015-04-01

A system and method for transporting a hyperpolarized substance is disclosed. A transport vessel 100 for transporting such a hyperpolarized substance includes a vessel housing 102, a chamber 104 formed within the vessel housing 102 that is configured to receive a container 106 holding a hyperpolarized substance, and an electromagnet 112 configured to generate a magnetic containment field about the chamber 104 when a current is supplied thereto, the magnetic containment field comprising a homogeneous magnetic field. The transport vessel 100 also includes a non-magnetic power source 118 to supply the current to the electromagnet and a control circuit 120 configured to selectively interrupt the supply of current to the electromagnet 112 so as to control generation of the magnetic containment field, with the transport vessel 100 being magnetically inert when the supply of current to the electromagnet 112 is interrupted by the control circuit 120.


Patent
Office of Technology Transfer | Date: 2015-06-12

Described herein are apparatus comprising: a first layer comprising a first microfluidic channel; a second layer comprising a second microfluidic channel; and a membrane for culturing cells; along with methods of making and using same.

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