Québec, Canada
Québec, Canada

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Lemieux J.,of Quebec Research Center | Lemieux J.,Saint Sacrement Hospital | Lemieux J.,University of Québec | Lemieux J.,Laval University | And 21 more authors.
Anticancer Research | Year: 2013

Background: Trastuzumab has no major sideeffects except the potential for cardiac toxicity. The main objective of this study was to evaluate the association between trastuzumab-Associated cardiac toxicity and two potential risk factors: alcohol intake and HER2 polymorphisms. Patients and Methods: In a retrospective cohort study of 237 women with non-metastatic HER2- positive breast cancer treated with trastuzumab, traditional risk factors were assessed by review of medical records, alcohol use by an administered questionnaire to women (n=132), and HER2 polymorphisms (Ile655Val and Ala1170Pro) using TaqMan assays (n=73). Results: Association was observed between alcohol intake (10 drinks and more per week) during the trastuzumab treatment and cardiac toxicity (p=0.04). For polymorphisms, compared to Ile/Ile carriers, HER2 Ile/Val was associated with a higher risk of cardiac toxicity (p=0.02). Conclusion: Heavy alcohol use during the course of trastuzumab treatment and the HER2 Ile/Val genotype may constitute risk factors for cardiac toxicity.


Furrer D.,Laval University | Furrer D.,of Quebec Research Center | Jacob S.,Deschenes Fabia Center for Breast Diseases | Jacob S.,Saint Sacrement Hospital | And 10 more authors.
Anticancer Research | Year: 2016

Aim: We examined an economical method for evaluating the amplification of the human epidermal growth factor receptor 2 (HER2) gene in breast cancer specimens. Materials and Methods: We compared HER2 amplification determined by fluorescence in situ hybridization (FISH) on whole-tissue (WT) blocks used for diagnostic and on tissue microarray (TMA) sections for a cohort of 521 consecutive patients with breast cancer. In a subset of 116 patients, we examined HER2 concordance from the WT section and a TMA section from a randomly chosen additional block (a proxy of the core biopsy). Results: Overall concordance for HER2 amplification between WT and TMA sections was 98.2%, and between sections from WT and from the additional block was 99.0%. Conclusion: The high concordance rates support the use of TMA for the evaluation of HER2 amplification in breast cancer and suggest that FISH can be used to assess HER2 using core biopsies.


PubMed | of Quebec Research Center
Type: Journal Article | Journal: Anticancer research | Year: 2013

Trastuzumab has no major side-effects except the potential for cardiac toxicity. The main objective of this study was to evaluate the association between trastuzumab-associated cardiac toxicity and two potential risk factors: alcohol intake and HER2 polymorphisms.In a retrospective cohort study of 237 women with non-metastatic HER2-positive breast cancer treated with trastuzumab, traditional risk factors were assessed by review of medical records, alcohol use by an administered questionnaire to women (n=132), and HER2 polymorphisms (Ile655Val and Ala1170Pro) using TaqMan assays (n=73).Association was observed between alcohol intake (10 drinks and more per week) during the trastuzumab treatment and cardiac toxicity (p=0.04). For polymorphisms, compared to Ile/Ile carriers, HER2 Ile/Val was associated with a higher risk of cardiac toxicity (p=0.02).Heavy alcohol use during the course of trastuzumab treatment and the HER2 Ile/Val genotype may constitute risk factors for cardiac toxicity.

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