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Gel'Mbol'Dt V.O.,Odessa National Medical University
Russian Journal of Inorganic Chemistry

The known data regarding the effects of interionic hydrogen bonding on properties of onium hexafluorosilicates with heterocyclic cations are summarized. Thermal stability parameters and water solubilities for this type of salts are shown to correlate with the number of strong and medium-strength hydrogen bonds or the number of hydrogen donors in the salt structure. © 2014 Pleiades Publishing, Ltd. Source

Kresyun N.V.,Odessa National Medical University
Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i

AIM: The characteristics of visual evoked potentials (VEP) have been studied in diabetic patients with and without diabetic retinopathy.MATERIAL AND METHODS: Magnetic impulses (2.0 T1 at the height of impulse) have been delivered to the cerebellar surface transcranially using the "Neuro-MS/D", (Russia Federation). Delta- sleep inducing peptide ("Deltalycyn", "Biopharma", Russia Federation) was intranasally delivered in 30 min before photostress. Afterwards VEP have been registered every 20 s from the moment of photo stress during one minute.RESULTS: An increase of the latency period and a reduction of the VEP amplitude have been recorded in the period following photo stress exposure of the macular part of the retina. The VEP characteristics restored to the initial level in 73.5 +/- 3.3 s from the photo stress moment in the control group; while in diabetic patients with retinopathy this index was 137.2 +/- 11.3 s. In the. presence of cerebellar transcranial magnetic stimulations (2.0 T1, 20 impulses) the VEP amplitude depression was less pro- nounced, and the restoration period of the VEP characteristics shortened to 110.3+ 12.7 s, while in deltalycyn treated patients restoration was observed in 95.1+ 6.8 s. Under condition of combined usage of deltalycyn and TMS period of restoration of VEP was shortened up to 82.5 +/- 6.5 s.CONCLUSIONS: Retinopathy development is linked to prolonged VEP latency period (P100), lowering of the N75-P100 amplitude, as well as to enlargement of the recovery period of the retina's functional capacity in patients suffering from the diabetes mellitus in the presence of photo stress. Superlatively administered deltalycyn and cerebellar transcranial magnetic stimulation facilitates a faster recovery of the retina's functional capacity in response to photo stress in diabetic patients with retinopathy. 3. Combined usage of deltalycyn and cerebellar transcranial stimulation caused the potentiated shortening of post-photo stress recovering of VEP in patients with diabetic retinopathy. Source

Matyushkina M.V.,Odessa National Medical University

Neurotropic effects of new coordination compounds, germacit and stanmacit, were tested on models of acute generalized convulsive activity induced in rats by injections of pentylenetetrazol (PTZ, 40 mg/kg), picrotoxin (PT, 2.0 mg/kg), or kainic acid (KA, 15 mg/kg). The tested biologically active substances were injected in doses corresponding to 1/10, 1/20, 1/40, 1/80, or 1/135 of the calculated LD50. Germacit provided obvious anticonvulsive effects in the case of seizure activity induced by PTZ (in a dose of 1/80 LD50), PT, and KA (in doses of 1/40 LD50); the intensity of convulsive manifestations decreased significantly compared with analogous indices in control groups (P < 0.05). Stanmacit did not influence the expression of acute PT-induced convulsions (P > 0.05) but intensified PTZ- and KA-induced seizures (at 1/20 and 1/40 LD50, respectively; P < 0.05). The obtained data are indicative of the ability of new complex coordination compounds of germanium and tin with magnesium and citric acid to significantly control the excitability of cerebral structures involved in the generation of epileptiform activity. © 2014, Springer Science+Business Media New York. Source

We studied the pathogenetic role of central structures belonging to epileptogenic and antiepileptogenic systems, namely the ventral hippocampus (VH), superior colliculus (SC), and frontal cortex, in the pathogenesis of pilocarpine-induced status epilepticus (with the presence of spontaneous seizures, SSs). Using a stereotaxic technique, the above-mentioned structures were subjected to preliminary local destruction (by microinjections of ibotenic acid) or electrostimulation in the course of the experiment. Pilocarpine-induced SSs were readily recorded in rats subjected to stimulation of the VH and frontal cortex, as well as to destruction of the SC. At the same time, in rats with destruction of the VH and frontal cortex but with activation of the SC, we observed no SS episodes. Therefore, the above-mentioned central structures play significant pathogenetic roles in the mechanisms underlying the development of the pilocarpine-induced epileptic state; the VH and frontal cortex are in reciprocal relations with the SC. © 2014 Springer Science+Business Media New York. Source

Kresyun N.V.,Odessa National Medical University | Godlevskii L.S.,Odessa National Medical University
Bulletin of Experimental Biology and Medicine

In 1.5 months after modeling of streptozotocin-induced diabetes mellitus, superoxide dismutase and catalase activities decreased by 40.7 and 32.0%, respectively, in comparison with the corresponding values in Wistar rats without diabetes. Electric stimulations (100 Hz, 0.25 msec, 50-100 μA, 2.5 sec) of the paleocerebellar cortex (V-VII lobules) were conducted 3 times a day over 1 month. These stimulations prevented the decrease in antioxidant enzyme activity in rats with experimental diabetes. © 2014, Springer Science+Business Media New York. Source

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