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Grubnik V.V.,Odessa National Medical University | Grubnik A.V.,Odessa National Medical University | Vorotyntseva K.O.,Odessa National Medical University
Wideochirurgia I Inne Techniki Maloinwazyjne | Year: 2014

Introduction: Laparoscopic incisional and ventral hernia repair (LIVHR) was first reported by Le Blanc and Booth in 1993. Many studies are available in the literature that have shown that laparoscopic repair of incisional and ventral hernia is preferred over open repair because of lower recurrence rates (less than 10%), less wound morbidity, less pain, and early return to work. Aim: To identify the long-term outcomes between the different types of meshes and two techniques of mesh fixation, i.e., tacks (method Double crown) and transfascial polypropylene sutures. Material and methods: A total of 92 patients underwent LIVHR at our department between January 2009 and August 2012. The hernias were umbilical in 26 patients, paraumbilical in 15 patients and incisional in 51 patients. All patients admitted for LIVHR were randomized to either group I (tacker fixation of ePTFE meshes) or group II (suture fixation of meshes with nitinol frame) using computer-generated random numbers with block randomization and sealed envelopes for concealed allocation. Results: The mean mesh fixation time was significantly higher in the tacker fixation group (117 ± 15 min vs. 72 ± 6 min, p < 0.01). There were no conversions in either group. The median postoperative hospital stay was 3.5 ± 1.5 days. All patients were followed up at 1, 3, 6, 12 and every 6 months thereafter postoperatively. There were 5 recurrences in the study population. In group I there were 4 patients with recurrence, and only 1 patient in the group with meshes with a nitinol frame. Conclusions: Meshes of the new generation with a nitinol framework can significantly improve laparoscopic ventral hernia repair. The fixation of these meshes is very simple using 3-4 transfascial sutures. The absence of shrinkage of these meshes makes the probability of recurrence minimal. Absence of tackers allows postoperative pain to be minimized. We consider that these new meshes can significantly improve laparoscopic ventral hernia repair.


We studied the pathogenetic role of central structures belonging to epileptogenic and antiepileptogenic systems, namely the ventral hippocampus (VH), superior colliculus (SC), and frontal cortex, in the pathogenesis of pilocarpine-induced status epilepticus (with the presence of spontaneous seizures, SSs). Using a stereotaxic technique, the above-mentioned structures were subjected to preliminary local destruction (by microinjections of ibotenic acid) or electrostimulation in the course of the experiment. Pilocarpine-induced SSs were readily recorded in rats subjected to stimulation of the VH and frontal cortex, as well as to destruction of the SC. At the same time, in rats with destruction of the VH and frontal cortex but with activation of the SC, we observed no SS episodes. Therefore, the above-mentioned central structures play significant pathogenetic roles in the mechanisms underlying the development of the pilocarpine-induced epileptic state; the VH and frontal cortex are in reciprocal relations with the SC. © 2014 Springer Science+Business Media New York.


Gel'mbol'dt V.O.,Odessa National Medical University | Anisimov V.Y.,Odessa National Medical University | Fonar' M.S.,Moldova Academy of Sciences
Russian Journal of Inorganic Chemistry | Year: 2016

Hexafluorosilicate (LH2)SiF6 and the cis-[SiF4(L)] chelate complex characterized by 19F NMR are products of reaction between hydrofluorosilicic acid and 1,10-phenanthroline (L). XRD findings show that the structure of (LH2)SiF6 is stabilized by NH···F hydrogen bonds (N···F 2.618(4), 2.676(4) Å) and CH···F contacts. The relative resistance of the cis-[SiF4(L)] complex to hydrolysis is associated with the chelate effect. © 2016, Pleiades Publishing, Ltd.


Kostyushov V.V.,Odessa National Medical University | Bokal I.I.,Odessa National Medical University
Biomeditsinskaya Khimiya | Year: 2010

In the article general conformities to law and features of violation of the thioldisulfid an redox system of whey of blood are described for patients with the without a symptom transmitter of HIV and manifestly forms AIDS. The role of her components is grounded - general, protein and non protein -SH, -S-S- groups in the mechanism of forming of oxidative stress and distress at HIV of infection. The clinic and laboratory criterions of expressed of peroxides processes are specified on the indexes of violation of redox transformations of -SH, -S-S- groups, neutralization and utilization of MDA and stability of LPC in the whey of blood at HIV of infection. Found out intercommunication between expressed of violation of the studied indexes, oxidative stress and distress and features of clinical flow of HIV of infection, allowed authors to attribute this pathology to "free radical diseases". In this connection, indicated analytic it is suggested to use as additional biochemical markers of oxidative stress and distress, and also for the ground of setting of antioxidants and their combinations in complex prophylactic or therapeutic application at HIV of infection.


Gelmboldt V.O.,Odessa National Medical University | Gelmboldt V.O.,Ukrainian Academy of Sciences
Russian Journal of Inorganic Chemistry | Year: 2012

The relationship between the water solubility of hexafluorosilicates with different types of onium cations and the characteristics of interionic H-bonds in their structures was analyzed. The antibate correlation between the solubility and the number of short interionic H-bonds was revealed for salts with aromatic heterocyclic and arylammonium cations. © Pleiades Publishing, Ltd., 2012.


Kresyun N.V.,Odessa National Medical University | Godlevskii L.S.,Odessa National Medical University
Bulletin of Experimental Biology and Medicine | Year: 2014

In 1.5 months after modeling of streptozotocin-induced diabetes mellitus, superoxide dismutase and catalase activities decreased by 40.7 and 32.0%, respectively, in comparison with the corresponding values in Wistar rats without diabetes. Electric stimulations (100 Hz, 0.25 msec, 50-100 μA, 2.5 sec) of the paleocerebellar cortex (V-VII lobules) were conducted 3 times a day over 1 month. These stimulations prevented the decrease in antioxidant enzyme activity in rats with experimental diabetes. © 2014, Springer Science+Business Media New York.


Gel'Mbol'Dt V.O.,Odessa National Medical University
Russian Journal of Inorganic Chemistry | Year: 2014

The known data regarding the effects of interionic hydrogen bonding on properties of onium hexafluorosilicates with heterocyclic cations are summarized. Thermal stability parameters and water solubilities for this type of salts are shown to correlate with the number of strong and medium-strength hydrogen bonds or the number of hydrogen donors in the salt structure. © 2014 Pleiades Publishing, Ltd.


Kresyun N.V.,Odessa National Medical University
Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i | Year: 2014

AIM: The characteristics of visual evoked potentials (VEP) have been studied in diabetic patients with and without diabetic retinopathy.MATERIAL AND METHODS: Magnetic impulses (2.0 T1 at the height of impulse) have been delivered to the cerebellar surface transcranially using the "Neuro-MS/D", (Russia Federation). Delta- sleep inducing peptide ("Deltalycyn", "Biopharma", Russia Federation) was intranasally delivered in 30 min before photostress. Afterwards VEP have been registered every 20 s from the moment of photo stress during one minute.RESULTS: An increase of the latency period and a reduction of the VEP amplitude have been recorded in the period following photo stress exposure of the macular part of the retina. The VEP characteristics restored to the initial level in 73.5 +/- 3.3 s from the photo stress moment in the control group; while in diabetic patients with retinopathy this index was 137.2 +/- 11.3 s. In the. presence of cerebellar transcranial magnetic stimulations (2.0 T1, 20 impulses) the VEP amplitude depression was less pro- nounced, and the restoration period of the VEP characteristics shortened to 110.3+ 12.7 s, while in deltalycyn treated patients restoration was observed in 95.1+ 6.8 s. Under condition of combined usage of deltalycyn and TMS period of restoration of VEP was shortened up to 82.5 +/- 6.5 s.CONCLUSIONS: Retinopathy development is linked to prolonged VEP latency period (P100), lowering of the N75-P100 amplitude, as well as to enlargement of the recovery period of the retina's functional capacity in patients suffering from the diabetes mellitus in the presence of photo stress. Superlatively administered deltalycyn and cerebellar transcranial magnetic stimulation facilitates a faster recovery of the retina's functional capacity in response to photo stress in diabetic patients with retinopathy. 3. Combined usage of deltalycyn and cerebellar transcranial stimulation caused the potentiated shortening of post-photo stress recovering of VEP in patients with diabetic retinopathy.


Matyushkina M.V.,Odessa National Medical University
Neurophysiology | Year: 2014

Neurotropic effects of new coordination compounds, germacit and stanmacit, were tested on models of acute generalized convulsive activity induced in rats by injections of pentylenetetrazol (PTZ, 40 mg/kg), picrotoxin (PT, 2.0 mg/kg), or kainic acid (KA, 15 mg/kg). The tested biologically active substances were injected in doses corresponding to 1/10, 1/20, 1/40, 1/80, or 1/135 of the calculated LD50. Germacit provided obvious anticonvulsive effects in the case of seizure activity induced by PTZ (in a dose of 1/80 LD50), PT, and KA (in doses of 1/40 LD50); the intensity of convulsive manifestations decreased significantly compared with analogous indices in control groups (P < 0.05). Stanmacit did not influence the expression of acute PT-induced convulsions (P > 0.05) but intensified PTZ- and KA-induced seizures (at 1/20 and 1/40 LD50, respectively; P < 0.05). The obtained data are indicative of the ability of new complex coordination compounds of germanium and tin with magnesium and citric acid to significantly control the excitability of cerebral structures involved in the generation of epileptiform activity. © 2014, Springer Science+Business Media New York.


Grubnik V.V.,Odessa National Medical University | Malynovskyy A.V.,Odessa National Medical University
Surgical Endoscopy and Other Interventional Techniques | Year: 2013

Background Mesh repair may decrease the recurrence rate but bears risk of esophageal complications. This study aimed to analyze the long-term results of laparoscopic hiatal repair depending on hiatal surface area (HSA). Methods The results from 658 procedures were analyzed. Group 1 had 343 patients with HSA smaller than 10 cm2 (small hernias), for whom primary crural repair was performed. Group 2 had 261 patients with HSA size 10-20 cm2 (large hernias), for whom primary crural repair (subgroup A) or mesh repair (subgroup B) was performed. Group 3 had 54 patients with HSA larger than 20 cm2 (giant hernias), for whom only mesh repair was performed. Results The mean follow-up period was 28.6 months (range, 10-48 months). Primary repair results in a higher recurrence rate for large hernias (11.9 %) than for small hernias (3.5 %) (p = 0.0016). For large hernias, the original method of sub-lay lightweight partially absorbable mesh repair provides a lower recurrence rate than primary repair (4.9 % vs 11.9 %; p = 0.0488) and a comparable dysphagia rate (2.1 % vs 2.2 %; p = 0.6533). For giant hernias, mesh repair results in a higher recurrence rate than for large hernias (20 % vs 4.9 %; p = 0.0028). The analysis of variance (ANOVA) HSA recurrence ratio confirmed the correctness of the chosen threshold levels (10 and 20 cm2) for subdividing hernias into three classes according to the new classification. Conclusions The authors advise routine measurement of HSA and use of relative classification, primary suturing as the optimal repair for small hernias, the original technique of sub-lay lightweight partially absorbable mesh repair as the apparent best treatment for large hernias, and the original technique for giant hernias, which provides results corresponding to those reported in the literature, although these results require improvement. © Springer Science+Business Media New York 2013.

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