Oddzial Urologii

Sosnowiec, Poland

Oddzial Urologii

Sosnowiec, Poland
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Holody-Zareba J.,Odzial Ginekologiczno Polozniczy | Kinalski P.,Odzial Ginekologiczno Polozniczy | Sulkowski S.,Dzial Diagnostyki Laboratoryjnej | Kozlowski R.,Oddzial Urologii | Kinalski M.,Odzial Ginekologiczno Polozniczy
Ginekologia Polska | Year: 2013

Renal cell carcinoma accounts for 75% of renal neoplasms. Clear cell carcinoma is diagnosed in about 80% of the cases. Renal cell carcinoma most frequently metastasizes to the lungs (50-60%), lymph nodes (36%), bones (30-40%), liver (30-40%), and brain (5%). In other organs the metastasis changes are observed very rarely. Ovarian me-tastases are found in 0.5% of renal cancers. So far, only 23 cases of renal cell carcinoma metastases to the ovary have been reported in the literature. In 18 cases they were metastases of renal cell carcinoma of the clear cell type. The authors present a case of a 50-year-old woman with double-sided metastatic changes to the ovary from renal cell carcinoma. The patient was admitted to the Gynecological ward with preliminary diagnosis of ovarian tumors. Gynecological examination revealed double-sided ovarian tumors, 6-7cm in diameter. Computed tomography also showed a 155×80 mm hetrogenous, multiform tumor localized above the uterus. In addition, CT showed a 75×55mm tumor in the lower pole, and a smaller one, 15mm in diameter, in the upper pole of the right kidney. Laboratory tests were normal. The antigen Ca 125 was 25 j/ml. Mammography, cytology, gastroscopy, colono-scopy were normal. The consulting urologist proposed a two-stage treatment. In the first stage, the removal of the double-sided ovarian tumors was proposed, while in the second stage the right nephrectomy was suggested. Double-sided ovarian tumors were found and removed (in the wall of the cyst- yellow, solid masses) during the first operation. Intraoperative histological examination showed changes with unknown grade of malignancy in both ovaries (number of studies QN 291). The patient underwent total hysterectomy. On day 5 postoperatively the woman was discharged from the hospital in good condition with the recommendation to pick up the histological test result in two weeks time. The final histological examination showed metastatic changes of renal cell carcinoma of the clear cell type (number of studies QN569-582, QN 585-608). The diagnosis of bilateral renal cell carcinoma metastases to the ovaries was confirmed by immunohistochemical studies using antibodies CD 10 and Vimentin (number of studies CT 1558-1559). The patient was directed to the Urological Ward. The surgery confirmed the presence of the tumor in the lower pole (about 8 cm in size), and a smaller one (about 1 cm in size) in the upper pole of the right kidney. The right nephrectomy was performed. Histological examination confirmed the primary clear cell renal cell carcinoma. The patient was directed to the next oncological treatment. ©Polskie Towarzystwo Ginekologiczne.


Drewniak T.,Oddzial Urologii | Wajdowicz A.,Jagiellonian University | Kwiatek W.,Henryk Niewodniczahski Institute of Nuclear Physics PAN | Juszczak K.,Oddzial Urologii | And 2 more authors.
Polski Merkuriusz Lekarski | Year: 2012

In industrialized countries, increasing concentrations of harmful trace elements in the human environment increases their concentration in the organs, which in tum may be responsible for the growth of cancer including cancer of the kidney. Trace elements by increasing the concentration of active free radicals damage cell DNA, and in a consequence increase the risk of carcinogenesis. The aim of this study: was to determine concentrations of biochemical markers providing an increase in the concentration of free radicals in the cell kidney cancer and renal cortical tissue, from which it originates and to attempt conflation of these markers with the concentration of carcinogenic trace elements identified in these same tissues using spectral analysis of PIXE (Proton induced X-Ray Emmision). Materials and methods: Of the 12 kidneys removed because of renal cell carcinoma clippings taken from the parenchyma of the kidney and kidney tumor, and then the concentration of markers of oxidative stress such as malonic dialdehyd (MDA), reduced form and oxidized glutathione and 1-ascorbic acid of the tissue. The concentration of elements was made by means of physical methods of analysis of multielemental PIXE (Proton Induced X-Ray Emission) in tumor tissue and kidney tissue of renal cortical tumor unchanged. Results: Malonic dialdehyd concentrations (MDA), reduced and oxidized forms of glutathione and 1-ascorbic acid were successively 2.11, 1.23, 0.84 and 2.25 fig/g for tissue kidney tumor and subsequently one, 58, 0.99, 0.58 and 2.3 pg/g in the kidney cortex from which the tumor originates. Demonstrated significant differences in MDA concentrations (p < 0.01) and the oxidized form of glutathione (p < 0.05). In the analysis of conelation between the concentrations of markers of the concentrations of elements are carcinogenic by IARC (International Agency for Research on Cancer) showed significant increase in the concentration of 1-ascorbic acid with increasing concentrations of lead in kidney tumor tissue. In the renal cortex increased concentrations of MDA and oxidized forms of glutathione was significantly correlated with increased levels of selenium. Conclusions: By markers of oxidative stress has been shown indirectly to increased metabolism of oxygen free radicals in kidney tumor tissue compared to kidney cortex tissue from which it derives. At the same time was selected markers concentration dependence of the concentration of the elements considered by the IARC human carcinogens. Confirmation of these results on a larger group of patients may become a contribution to the study of substances that protect the kidney against carcinogens storage elements or substances that reduce oxidative stress in the kidney.


Bugajska K.,AGH University of Science and Technology | Skalski A.,AGH University of Science and Technology | Drewniak T.,Oddzial Urologii | Gajda J.,AGH University of Science and Technology
Przeglad Elektrotechniczny | Year: 2015

In the article we have proposed an application of several image processing algorithms to extract renal vessels. Earlier identification of the tumor feeding arteries facilitates conducting a zero-ischemia partial nephrectomy and preservation of renal function. This minimally invasive procedure is also beneficial for a patient. The study began with vascular structures segmentation of anatomical preparations. To do this hysteresis thresholding was applied to three dimensional computer tomography images. It allowed to obtain an initialization function for subsequently applied segmentation method – i.e. the level set method. The results confirmed the effectiveness of described methods -visually, in comparison to initial binarization, the acquired structures continuity had been found better and the objects boundaries were properly mapped. In addition, quantitative analysis involving the comparison of segmentation results with manual ones had been found satisfactory, that encourages to continue further research. © 2015, Przegląd Elektrotechniczny. All rights reserved.


A case of effective and save treatment of stones in patient with solitary kidney using a minimally invasive surgical techniques was presented. Treatment consisted of complete removal of stagehorn calculi in solitary kidney using percutaneous nephrolithotrypsy ( PCNL). Copyright © 2012 by Via Medica.


The main problem in nephron sparing surgery (NSS) is to preserve renal tumors oncological purity during the removal of the tumor with a margin of macroscopically unchanged kidney tissue while keeping the largest possible amount of normal parenchyma of the operated kidney. The development of imaging techniques, in particular IGT (Image Guided Therapy) allows precise imaging of the surgical field and, therefore, is essential in improving the effectiveness of NSS (increase of nephron sparing with the optimal radicality). The aim of this study was to develop a method of the three-dimensional (3D) imaging of the kidney tumor and its lodge in the operated kidney using 3D laser scanner during NSS procedure. Additionally, the animal model of visualization was developed. The porcine kidney model was used to test the set built up with HD cameras and linear laser scanner connected to a laptop with graphic software (David Laser Scanner, Germany) showing the surface of the kidney and the lodge after removal the chunk of renal parenchyma. Additionally, the visualization and reconstruction was performed on animal porcine model. Moreover, 5 patients (3 women, 2 men) aged from 37 to 68 years (mean 56), diagnosed with kidney tumors in CT scans with a diameter of 3.7-6.9 cm (mean 4.9) were operated in our Department this year, scanning the surface during the treatment with the kidney tumor and kidney tumor after it is removed with a margin of renal tissue. In one case, the lodge of removed tumor was scanned. Dimensions in 3D reconstruction images of laser scans in the study of animal model and the images obtained intraoperatively were compared with the dimensions evaluated during preoperative CT scans, intraoperative measurements. Three-dimensional imaging laser scanner operating field loge resected tumor and the tumor on the kidney of animal models and during NSS treatments for patients with kidney tumors is possible in real time with an accuracy of -2 mm do +9 mm (+/- 3 mm). The duration of data acquisition by laser scanner and obtain three-dimensional image of the operating field takes an average of 13 seconds +/- 2 seconds. Movements associated with breathing and heart rate did not affect on the quality of the reconstruction. The imposition of the scanned surface texture occurs in real time, allowing you to identify renal parenchymal structures such as renal cortex, pyramids, pyelo-calices complex. Imaging control of NSS procedures is possible in animal models and in real time intraoperatively. The comparison of tumor size and the tumor lodge obtained in preoperative CT scans with the measurements during NSS procedure provide the surgeon to assess the extent of macroscopic estimation of the resection. This procedure helps the surgeon in obtaining oncological radicality with saving as much normal tissue kidney as possible. Performance of the imaging methods should be evaluated on a larger group of patients with kidney tumors eligible for NSS treatment.


Pilch P.,Oddzial Urologii
Wiadomości lekarskie (Warsaw, Poland : 1960) | Year: 2012

The aim of the work is to analyze the influence of higher cholesterol and LDL level on risk of prostate cancer. The work is based on the available literature in that field. The metabolism of cholesterol is mainly regulated by the statins, which may thus inhibit prostate cancer growth. Keeping the appropriate body mass and level of cholesterol by proper diet and physical exercises may be the prophylaxis of prostate cancer.


The disturbed balance between production of reactive oxygen and nitrogen species (RONS) and efficiency of antioxydative systems leads to oxidative stress. This may be the cause of permanent biomolecules' damage. The results of many researches show dependence between disturbance in oxidative balance. And oxidative damage in prostate cells. However no clear evidence have been found that oxidative stress may lead to development of prostate cancer.


PubMed | Oddzial Urologii
Type: Journal Article | Journal: Folia medica Cracoviensia | Year: 2012

The main problem in nephron sparing surgery (NSS) is to preserve renal tumors oncological purity during the removal of the tumor with a margin of macroscopically unchanged kidney tissue while keeping the largest possible amount of normal parenchyma of the operated kidney. The development of imaging techniques, in particular IGT (Image Guided Therapy) allows precise imaging of the surgical field and, therefore, is essential in improving the effectiveness of NSS (increase of nephron sparing with the optimal radicality).The aim of this study was to develop a method of the three-dimensional (3D) imaging of the kidney tumor and its lodge in the operated kidney using 3D laser scanner during NSS procedure. Additionally, the animal model of visualization was developed.The porcine kidney model was used to test the set built up with HD cameras and linear laser scanner connected to a laptop with graphic software (David Laser Scanner, Germany) showing the surface of the kidney and the lodge after removal the chunk of renal parenchyma. Additionally, the visualization and reconstruction was performed on animal porcine model. Moreover, 5 patients (3 women, 2 men) aged from 37 to 68 years (mean 56), diagnosed with kidney tumors in CT scans with a diameter of 3.7-6.9 cm (mean 4.9) were operated in our Department this year, scanning the surface during the treatment with the kidney tumor and kidney tumor after it is removed with a margin of renal tissue. In one case, the lodge of removed tumor was scanned. Dimensions in 3D reconstruction images of laser scans in the study of animal model and the images obtained intraoperatively were compared with the dimensions evaluated during preoperative CT scans, intraoperative measurements.Three-dimensional imaging laser scanner operating field loge resected tumor and the tumor on the kidney of animal models and during NSS treatments for patients with kidney tumors is possible in real time with an accuracy of -2 mm do +9 mm (+/- 3 mm). The duration of data acquisition by laser scanner and obtain three-dimensional image of the operating field takes an average of 13 seconds +/- 2 seconds. Movements associated with breathing and heart rate did not affect on the quality of the reconstruction. The imposition of the scanned surface texture occurs in real time, allowing you to identify renal parenchymal structures such as renal cortex, pyramids, pyelo-calices complex.Imaging control of NSS procedures is possible in animal models and in real time intraoperatively. The comparison of tumor size and the tumor lodge obtained in preoperative CT scans with the measurements during NSS procedure provide the surgeon to assess the extent of macroscopic estimation of the resection. This procedure helps the surgeon in obtaining oncological radicality with saving as much normal tissue kidney as possible. Performance of the imaging methods should be evaluated on a larger group of patients with kidney tumors eligible for NSS treatment.


PubMed | Oddzial Urologii
Type: Journal Article | Journal: Przeglad lekarski | Year: 2013

The disturbed balance between production of reactive oxygen and nitrogen species (RONS) and efficiency of antioxydative systems leads to oxidative stress. This may be the cause of permanent biomolecules damage. The results of many researches show dependence between disturbance in oxidative balance. And oxidative damage in prostate cells. However no clear evidence have been found that oxidative stress may lead to development of prostate cancer.


PubMed | Oddzial Urologii
Type: Journal Article | Journal: Wiadomosci lekarskie (Warsaw, Poland : 1960) | Year: 2012

The aim of the work is to analyze the influence of higher cholesterol and LDL level on risk of prostate cancer. The work is based on the available literature in that field. The metabolism of cholesterol is mainly regulated by the statins, which may thus inhibit prostate cancer growth. Keeping the appropriate body mass and level of cholesterol by proper diet and physical exercises may be the prophylaxis of prostate cancer.

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