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Bydgoszcz, Poland

Krzywy I.,Oddzial Pediatrii
Annales Academiae Medicae Stetinensis | Year: 2010

Lead (PB, latin name plumbum) is a heavy metal commonly found in nature. In the environment it is not biodegradable nor does it undergo dissociation. It can accumulate in the tissues of living organisms. Throughout the years the attitude towards lead has changed. Once widely used, currently considered a big threat to the health ofa human. The development of civilization and associated with it an increase of lead emission contributes to a major contamination of the natural Pb environment. The authors have focused attention on the causes and effects on the environmental contamination of lead on human health. Environmental and occupational dangers of lead exposition have been discussed. Strict interdependence between the dose and time of exposition, its concentration in tissues and the appearance of clinical symptoms among humans have been stressed. Additionally, rules of controlling lead concentration in natural environments and places of work with the aim of avoiding lead poisoning have been discussed. Source

Wilczynska D.,Nicolaus Copernicus University | Lezyk-Ciemniak E.,Nicolaus Copernicus University | Kobusinska K.,Oddzial Pediatrii | Grzesk E.,Nicolaus Copernicus University | And 4 more authors.
Pediatria Polska | Year: 2016

Introduction Fever is one of the most common reasons why parents and a child go to the pediatrician. Fever of unknown origin (FUO) is a very difficult diagnostic problem. Objective The study aims were retrospective analysis of causes of FUO and periodic fevers in children and trying to prepare a diagnostic algorithm. Material and methods The study involved 77 children, aged 1-19 years who were hospitalized in the Department of Pediatrics, Oncology and Hematology and the Department of Pediatrics, Cardiology and Rheumatology in the years 2005-2011. Since the work is retrospective, qualifications for the study took place on the basis of medical records such as a medical history. The study group included children who had a temperature over 38 °C lasting more than 3 weeks or appearing on a regular basis every 3-4 weeks without an obvious cause. Results The most common cause of FUO was neoplastic diseases (48%), especially acute lymphoblastic leukemia. Other diagnoses were made in 41.6%. Among them, in 15.6% patients autoimmune diseases and other immunological syndromes, in 7.8% periodic fever syndromes and in 18.2% infectious diseases were diagnosed. 10.4% patients were without final diagnosis. Very important in diagnostic process was analysis of concomitant signs and symptoms. Conclusions Infectious, autoimmune and noeplastic diseases should be concerned in a differential diagnosis of FUO. Appropriate questions, physical examinations and basic laboratory tests often allow to make the correct diagnosis. The proposed diagnostic algorithm might be helpful to a successful diagnostic process. © 2016 Polish Pediatric Society. Source

Czaja-Bulsa G.,Zaklad Pielegniarstwa Pediatrycznego | Jakubik M.,Oddzial Pediatrii
Pediatria Wspolczesna | Year: 2012

Introduction: In the pathogenesis of the eosinophilic esophagitis (EoE) a crucial role is played by genetic factors, exposition to food and environmental allergens and the IgE-dependent activation of the immunological system. Aim of the study: The incidence of atopy and allergies as well as the EoE children's response to treatment. Material and methods: The study covered 14 children (3 girls, 11 boys) at the average age of 9.2 years (aged 8 months to 17 years), whose esophageal mucosa contained at least 15 eosinophils (18-80) per high power field (×400). The diagnostic procedures included the analysis of medical records and clinical manifestations, prick and patch tests as well as an open elimination and provocation test. The results of treatment by means of elimination diet as well as topical and systemic steroids were also analysed. Results: Food allergy was diagnosed in 64% of children, inhalatory allergy - in 57%. Food related EoE was diagnosed in 3 (21%) children. Clinical response was achieved in 86% of children: in three of them after food elimination, in two - after fluticasone treatment and in seven of the patients following a 3-6-month administration of prednisone (all the children suffered from asthma bronchiale). Conclusions: 1. The group at risk of the EoE are children suffering from allergies. 2. The EoE therapy includes an elimination diet as well as topical and systemic steroids. Administration of topical steroids is effective in children who do not suffer from bronchial asthma. In children with bronchial asthma therapeutic effects are achieved no sooner than after several months of treatment with systemic steroids. Copyright © 2012 Cornetis. Source

Sawilska-Tanska M.,Oddzial Pediatrii | Pawlowska M.,Klinika Chorob Zakaznych i Hepatologii Wieku Rozwojowego | Wietlicka-Piszcz M.,Katedra Podstaw Teoretycznych Nauk Biomedycznych i Informatyki Medycznej CM UMK
Pediatria Polska | Year: 2016

The aim of the study was to estimate the changes in the clinical course and treatment of meningitis in children hospitalized at the Hospital of Infectious Diseases in Bydgoszcz during the years 1989-2010. Material and methods 184 treated children (96 boys and 88 girls) aged from 2 weeks to 18 years, underwent epidemiology, clinical course and treatment of meningitis. Results The etiology detection was 57.1%. Most common pathogens were Neisseria meningitidis (25.00%), Haemophilus influenzae (19.02%) and Streptococcus pneumoniae (8.69%). In the youngest group of patients, the most common causes of meningitis were group B Streptococcus and Salmonella. There were high inflammatory markers in the blood and high pleocytosis in the cerebrospinal fluid. Top rates of these indexes, as well as a serious course of the disease, were observed in meningitis due to Streptococcus pneumoniae. Conclusions Throughout the analyzed time a significant decrease in meningitis incidence was observed.The etiological changes of meningitis through the years reflect the introduction of active immunoprophylaxis and suggest a possibility of the occurrence of meningitis due to non-vaccination strains.An increase in the incidence of meningitis due to Streptococcus pneumoniae and Neisseria meningitidis C as well as its serious clinical course signalizes the need of vaccination recommendation.Inflammation markers indicate a correlation with the patient's clinical condition and the dynamism of the illness process.Higher antibiotic therapy efficacy results in shorter meningitis treatment duration. © 2015 Polish Pediatric Society. Source

Mazur-Zielinska H.,laski University Medyczny towicach | Zielinski M.,laski University Medyczny towicach | Pilarz L.,laski University Medyczny towicach | Karbowska D.,Oddzial Pediatrii | Birkner E.,laski University Medyczny towicach
Pediatria Polska | Year: 2015

The imbalance of oxidative and antioxidative processes occurs in the course of various diseases. Objectives The aim of the study was the assessment of TAC and TOS value in children with juvenile idiopathic arthritis (JIA). Methods The studied parameters were measured in blood serum taken from 30 patients with JIA. Patients' age ranged from 2 to 18 years. They were hospitalized in the Rheumatology Division of the Department of Pediatrics or followed up in Rheumatology Outpatient Clinic, Silesian Medical University. The control group consisted of 18 healthy children aged from 2 to18 years. Results There were a significant difference of TOS levels in children with JIA (mean value: healthy children 14.45 ± 48.48 μmol/l, children with JIA 64.42 ± 44.81 μmol/l, p < 0.05). TAC levels were similar in both groups (mean value: healthy children 0.82 ± 0.08 mmol/l, children with JIA 0.83 ± 0.12 mmol/l, p > 0.05). Conclusion Oxidative/antioxidative processes are affected in the course of JIA. TOS can be used as an inflammation marker in JIA. © 2015 Polish Pediatric Society. Published by Elsevier Sp. z o.o. All rights reserved. Source

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