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Prague, Czech Republic

Kozisek F.,Oddeleni hygieny vody | Kozisek F.,Charles University | Jeligova H.,Oddeleni hygieny vody
Casopis Lekaru Ceskych | Year: 2012

Increasing consumption of pharmaceuticals leads also to higher release of its non-metabolized residues into environment, mostly hydrosphere. Some of these substances may reach also processed drinking water. Although it is found in traces, it causes public concern as it can represent a non-targeted and unwanted medication. Toxicologists and public health authorities are appealed to assess potential health risks carefully and to communicate the risk adequately to public. As health risks assessment of environmental exposure to pharmaceuticals is a new field of expertise, its methodology has not been unified and standardized yet, but several different procedures have been proposed and used. The paper provides overview of these methods. Source


Pomykacova I.,Oddeleni hygieny vody | Cadek V.,Oddeleni hygieny vody | Svobodova V.,Oddeleni hygieny vody | Kozisek F.,Oddeleni hygieny vody | Jeligova H.,Oddeleni hygieny vody
Chemicke Listy | Year: 2012

The aim of this study was GC-MS screening of drinking water supplies for the presence of traces of pharmaceuticals. The target analytes were naproxen, ibuprofen, diclofenac, carbamazepine and 17α-ethynylestradiol. Solid -phase extraction (SPE) was used for for their preconcetration. Derivatization of target analytes in the eluted extracts was performed using N-(tert-butyldimethylsilyl)-N- -methyltrifluoroacetamide. Limits of quantification were less than 0.5 ng/L for naproxen, ibuprofen, diclofenac, carbamazepine and less than 2.0 ng/L for α-ethynylestradiol. The presence of target pharmaceuticals in drinking water in the Czech Republic is very rare; their concentrations range on the ng/L level. Source

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