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Madīnat Sittah Uktūbar, Egypt

Khamis H.,October 6th University | Abdelaziz A.,Cairo University | Ramzy A.,Benha University
Egyptian Heart Journal | Year: 2014

Objectives: To evaluate the feasibility, efficacy, and safety of catheter-based radiofrequency renal sympathetic denervation for treatment of resistant hypertension. Background: In a subpopulation of patients with essential hypertension, therapeutic targets are not met, despite the use of multiple types of medication. In this paper we describe our first experience with a novel percutaneous treatment modality using renal artery radiofrequency (RF) ablation. Methods: Thirty patients with essential hypertension unresponsive to at least three types of antihypertensive medical therapy (baseline office systolic blood pressure ≥160. mmHg) were selected between March and September 2012 and received percutaneous RF ablation. Patients were followed up for 6. months after treatment. The primary effectiveness endpoint was change in seated office-based measurement of systolic blood pressure at 6. months. Another thirty patients were taken as control. Results: A reduction of mean office blood pressure was seen from 170/102. ±. 9/5. mmHg at baseline to 151/91. ±. 8/6. mmHg at 6. months follow-up (p= 0.001). Also, we noted a significant decrease in plasma renin activity (3.66. ±. 0.64 versus 3.37. ±. 0.47. ng/mL/h; p= 0.003). No periprocedural complications, adverse events or change in renal function were noted during follow-up. Conclusion: Catheter-based renal denervation seems an attractive minimally invasive treatment option in patients with resistant hypertension, with a low risk of serious adverse events. © 2013. Source

Hussein M.A.,October 6th University
International Journal of Phytomedicine | Year: 2011

Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a stilbenoid, a type of natural phenol, and a phytoalexin produced naturally by several plants when under attack by pathogens such as bacteria or fungi was evaluated for possible antioxidant and free radical scavenging activities. Different antioxidant tests were employed, namely, reducing power, chelating activity on Fe2, free radical-scavenging, total antioxidant, superoxide radical scavenging, hydrogen peroxide scavenging and hydroxyl radical scavenging activities. In addition, the results were compared with natural and synthetic antioxidants, such as - tocopherol, ascorbic acid, butylated hydroxytoluene(BHT), butylated hydroxyanisole (BHA) and trolox. Resveratrol exhibited a strong reducing power, chelating activity on Fe2, free radical-scavenging, hydrogen peroxide scavenging and hydroxyl radical scavenging activities. Antioxidant activity of resveratrol increased with increased concentrations.Total antioxidant activity of resveratrol and both standards decreased in the order of -tocopherol > resveratrol > trolox > BHA > BHT. This study showed that resveratrol exhibited antioxidant activity in all tests and could be considered as a source of natural antioxidants. Source

Singab A.-N.B.,Ain Shams University | El-Hefnawy H.M.,Cairo University | Esmat A.,Ain Shams University | Gad H.A.,Ain Shams University | Nazeam J.A.,October 6th University
Phytotherapy Research | Year: 2015

Since ancient times, plants and herbal preparations have been used as medicine. Research carried out in the last few decades has verified several such claims. Aloe arborescens Miller, belonging to the Aloe genus (Family Asphodelaceae), is one of the main varieties of Aloe used worldwide. The popularity of the plant in traditional medicine for several ailments (antitumor, immunomodulatory, antiinflammatory, antiulcer, antimicrobial and antifungal activity) focused the investigator's interest on this plant. Most importantly, the reported studies have shown the plant effectiveness on various cancer types such as liver, colon, duodenal, skin, pancreatic, intestinal, lung and kidney types. These multiple biological actions make Aloe an important resource for developing new natural therapies. However, the biological activities of isolated compounds such as glycoprotein, polysaccharides, enzyme and phenolics were insufficient. Considering all these, this contribution provides a systematic review outlining the evidence on the biological efficacy of the plant including the pharmacology and the related mechanisms of action, with specific attention to the various safety precautions, and preclinical and clinical studies, indicating the future research prospects of this plant. © 2015 John Wiley & Sons, Ltd. Source

Khamis H.,October 6th University | Ramzy A.,Benha University | Elmelegy N.,Benha University | Elrabbat K.,Benha University | Masoud A.,Benha University
Egyptian Heart Journal | Year: 2016

Background: Atrial fibrillation (AF) is considered the major cause of stroke in the elderly. Alternative therapies to the anticoagulant therapy are warranted, particularly in patients who are ineligible or at high risk of bleeding. The left atrial appendage (LAA) is a prominent source of thrombi in nonvalvular AF, accounting for 90% of thrombi. As a result, surgical and transcatheter techniques have been explored to reduce the risk of stroke in patients with AF by occluding the LAA. Objectives: To assess the safety and efficacy of LAA closure in patients with nonvalvular atrial fibrillation (AF) ineligible for warfarin therapy. Methods: A prospective study that evaluated LAA closure with the Watchman device (Boston Scientific, Natick, MA; group A) in fifteen patients with nonvalvular AF and CHADS2 (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, and prior stroke or transient ischemic attack) score ≥1, who were considered ineligible for warfarin therapy. The primary efficacy endpoint was the combined events of ischemic/hemorrhagic stroke, systemic embolism and cardiovascular/unexplained death during a period of six months follow-up. Results: Successful closure of the LAA using the Watchman device was achieved in 15 patients (100%). The mean age was found to be 67.9 ± 9 years with 40% of them being males. No device or procedure related adverse events were detected. The mean CHADS2 score was 2.4 ± 0.8, while the mean CHA2DS2-VASC score was 4.4 ± 1.0. After a mean period of 8 ± 2 months of follow-up, no device dislodgement or device-related thrombi were documented. The all-cause stroke (ischemic and hemorrhagic) and systemic embolism were 0%. The device and procedure related mortality was found to be 0%. Only one patient died after 8 months of device implantation from pneumonia. Conclusion: LAA closure with the Watchman device can be safely performed, and may be a reasonable alternative to consider for patients at high risk for stroke but with contraindications to systemic oral anticoagulation or with high risk of bleeding. © 2016. Source

Kheiralla Z.H.,Ain Shams University | Abdelnasser M.,Al - Azhar University of Egypt | Rushdy A.A.,Ain Shams University | Othman A.S.,October 6th University
Journal of Pure and Applied Microbiology | Year: 2014

This study evaluated the antimicrobial efficacy of five biocides (disinfectants and antiseptics) on multidrug resistant isolates of Staphylococcus aureus. Disinfectants and antiseptics, used were chlorohexidine/cetrimide (savlon), povidone-iodine (betadine), ethyl alcohol (ethanol), sodium hypochlorite (chlorax) and glutaraldehyde (cidex). Eightythree isolates out of 200 collected samples (41.5%) were identified as S. aureus and were screened for their sensitivity to methicillin and oxacillin. Two isolates MRSA/ORSA and ORSA were examined for their susceptibility to the above mentioned disinfectants and antiseptics. The highest concentration of these disinfectants and antiseptics were the most effective ones on both isolates. MRSA/ORSA and ORSA became more susceptible after re-inoculation with different kinds of disinfectants and antiseptics except ethyl alcohol which showed no effect. The combination between two disinfectants to overcome the microbial resistance was studied. The inhibition zone of combination between two biocides (chlorhexidine/cetrimide & povidone-iodine) increases a little more than that with each antiseptic alone in case of double resistant isolate. The combination was less inhibitory when chlorhexidine/cetrimide was tested with single resistant isolate, but more inhibitory than the povidone-iodine at both higher and lower concentrations. Source

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