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Procopet B.,University of Medicine and Pharmacy, Cluj-Napoca | Procopet B.,Regional Institute of Gastroenterology and Hepatology Octavian Fodor | Procopet B.,CIBER ISCIII | Berzigotti A.,CIBER ISCIII
Current Hepatology Reports | Year: 2014

The diagnosis of cirrhosis and portal hypertension is critical for the correct management and follow-up of patients with chronic liver disease. Non-invasive methods to safely replace liver biopsy and hepatic venous pressure gradient measurement have been increasingly studied in the last 20 years. This review summarizes the available data regarding validated non-invasive methods to diagnose cirrhosis and clinically significant portal hypertension, and provides insight on new technologies (including different elastography techniques, novel imaging methods and combination of tests) that substantially improve the diagnostic armamentarium in this field. © 2014 Springer Science+Business Media New York.


Procopet B.,University of Medicine and Pharmacy, Cluj-Napoca | Procopet B.,Regional Institute of Gastroenterology and Hepatology Octavian Fodor | Procopet B.,Liver Unit | Berzigotti A.,Liver Unit
Current Hepatitis Reports | Year: 2014

The diagnosis of cirrhosis and portal hypertension is critical for the correct management and follow-up of patients with chronic liver disease. Non-invasive methods to safely replace liver biopsy and hepatic venous pressure gradient measurement have been increasingly studied in the last 20 years. This review summarizes the available data regarding validated non-invasive methods to diagnose cirrhosis and clinically significant portal hypertension, and provides insight on new technologies (including different elastography techniques, novel imaging methods and combination of tests) that substantially improve the diagnostic armamentarium in this field. © 2014 Springer Science+Business Media.


Tantau M.,University of Medicine and Pharmacy Iuliu Hatieganu | Tantau M.,Regional Institute of Gastroenterology and Hepatology Octavian Fodor | Procopet B.,University of Medicine and Pharmacy Iuliu Hatieganu | Procopet B.,Regional Institute of Gastroenterology and Hepatology Octavian Fodor | Bureau C.,University Paul Sabatier
Journal of Gastrointestinal and Liver Diseases | Year: 2013

Portal hypertension is a major consequence of any chronic liver disease and it represents the main mechanism of complication occurrence. Therefore, the assessment of portal hypertension presence is one of the most important steps in the management of any chronic liver diseases. The most accurate tool for portal pressure assessment is hepatic venous pressure gradient (HVPG) measurement, which has diagnostic and prognostic relevance. In this paper we review the methodology of HVPG measuring, together with the clinical relevance of this technique. Portal hypertension is denned as a HVPG higher than 5 mmHg, but clinically significant portal hypertension that predisposes to clinical decompensation is defined as HVPG higher than 10 mmHg. HVPG is useful for portal hypertension treatment monitoring. A decrease in HVPG greater than 20% or under the threshold of 12 mmHg is considered to be protective against portal hypertension-related events. Even if HVPG measurement is a safe procedure, it is still considered an invasive technique and not widely available. Therefore, non-invasive markers of portal hypertension were searched for. Until now only liver stiffness measurement by transient elastography has proved to be sufficiently accurate but there is still heterogeneity among the cut-off values for portal hypertension diagnosis.


Peng H.,Johns Hopkins Hospital | Peng H.,Sun Yat Sen University | Ishida M.,Johns Hopkins Hospital | Li L.,Johns Hopkins Hospital | And 24 more authors.
Oncotarget | Year: 2015

The complex regulation of tumor suppressive gene and its pseudogenes play key roles in the pathogenesis of hepatocellular cancer (HCC). However, the roles played by pseudogenes in the pathogenesis of HCC are still incompletely elucidated. This study identifies the putative tumor suppressor INTS6 and its pseudogene INTS6P1 in HCC through the whole genome microarray expression. Furthermore, the functional studies - include growth curves, cell death, migration assays and in vivo studies - verify the tumor suppressive roles of INTS6 and INTS6P1 in HCC. Finally, the mechanistic experiments indicate that INTS6 and INTS6P1 are reciprocally regulated through competition for oncomiR-17-5p. Taken together, these findings demonstrate INTS6P1 and INTS6 exert the tumor suppressive roles through competing for oncomiR-17-5p. Our investigation of this regulatory circuit reveals novel insights into the underlying mechanisms of hepatocarcinogenesis.


Miron N.,University of Medicine and Pharmacy, Cluj-Napoca | Miron N.,Regional Institute of Gastroenterology and Hepatology Octavian Fodor | Susman S.,University of Medicine and Pharmacy, Cluj-Napoca | Susman S.,The Oncology Institute Prof Dr I Chiricuta | And 10 more authors.
Journal of Gastrointestinal and Liver Diseases | Year: 2012

Colorectal cancer is an important disease of the modern world, generating significant mortality and morbidity rates. Its therapy, although considerably improved, continues to be unhelpful for a large percentage of patients, especially for those in advanced stages. This justifies the efforts toward producing new therapies, as well as for stratifying patients according to risk factors and prediction of therapeutic response. In this respect, the contributions of modern science are essential for defining the most intimate mechanisms and players of tumorigenesis and for proposing new biomarkers. The study of antitumor immune responses has revealed new insights into the tumor microenvironment, leading to the development of vaccines and adoptive transfer of immunocompetent cells. Circulating tumor cells are a real opportunity to detect early relapses and to define risk categories, while miRNAs, a family of small non-coding RNA implicated in regulation of gene expression, evolved as a new class of biomarkers with high potential for diagnosis, prognosis and prediction of colorectal cancers.

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