Prof Dr Octavian Fodor Regional Institute Of Gastroenterology And Hepatology

Cluj-Napoca, Romania

Prof Dr Octavian Fodor Regional Institute Of Gastroenterology And Hepatology

Cluj-Napoca, Romania
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PubMed | Victor Babes University of Medicine and Pharmacy Timisoara, Technical University of Cluj Napoca, University of Medicine and Pharmacy, Cluj-Napoca, Prof Dr Octavian Fodor Regional Institute Of Gastroenterology And Hepatology and Emergency County Hospital
Type: Review | Journal: Journal of gastrointestinal and liver diseases : JGLD | Year: 2016

There has been great interest in the development of non-invasive techniques for the diagnosis of liver fibrosis in chronic liver diseases, including ultrasound elastographic methods. Some of these methods have already been adequately studied for the non-invasive assessment of diffuse liver diseases. Others, however, such as two-dimensional Shear Wave Elastography (SWE), of more recent appearance, have yet to be validated and some aspects are for the moment incompletely elucidated. This review discusses some of the aspects related to two-dimensional SWE: the examination technique, the examination performance indicators, intra and interobserver agreement and clinical applications. Recommendations for a high-quality examination technique are formulated.


PubMed | Emergency Clinical County Hospital, Ion Chiricuta Oncology Institute, Prof Dr Octavian Fodor Regional Institute Of Gastroenterology And Hepatology and Municipal Hospital Dr A Simionescu Hunedoara
Type: Journal Article | Journal: Clujul medical (1957) | Year: 2015

Upper gastrointestinal bleeding (UGIB) is one of the most common emergencies in gastroenterology practice. In recent years, the introduction of urgent upper gastrointestinal endoscopy (UGIE) and of the treatment with proton pump inhibitors (PPIs) in high doses has resulted in an improvement of the treatment outcome in patients with UGIB, but without a significant improvement in mortality rates. In our study we compared the epidemiological, clinical, therapeutic, and prognostic aspects in patients with non-variceal UGIB admitted over a period of one year in a tertiary center where urgent UGIE is a routine procedure and in a municipal hospital where UGIE with endoscopic hemostasis is not available. Patients admitted to the tertiary medical center had more clinical and endoscopic severity factors compared to those from the municipal hospital: they were older, with more frequent intake of NSAIDs, several comorbidities, some of them severe, and more severe posthemorrhagic anemia. The endoscopic examination revealed that active bleeding and stigmata of recent hemorrhage were more frequent in these patients. Urgent UGIE and, where necessary because of lesions, endoscopic hemostasis were performed in most of these patients. Patients admitted to the municipal hospital were treated more frequently with high-dose intravenous PPIs. Patients undergoing urgent UGIE and endoscopic therapy had a shorter duration of hospitalization. However, there were no differences regarding the need for surgery or mortality rates. The results of our study are consistent with the literature.


PubMed | University of Medicine and Pharmacy, Cluj-Napoca, Prof Dr Octavian Fodor Regional Institute Of Gastroenterology And Hepatology, Polisano Clinic and Lucian Blaga University
Type: Case Reports | Journal: Journal of gastrointestinal and liver diseases : JGLD | Year: 2015

A fecal microbiota transplant has proved to be an extremely effective method for patients with recurrent infections with Clostridium difficile. We present the case of a 65-year-old female patient with multiple Clostridium difficile infection (CDI) relapses on the rectal remnant, post-colectomy for a CDI-related toxic megacolon. The patient also evidenced associated symptomatic Clostridium difficile vaginal infection. She was successfully treated with serial fecal minitransplants (self-administered at home) and metronidazole ovules.


Bartos A.,Prof Dr Octavian Fodor Regional Institute Of Gastroenterology And Hepatology | Bartos D.,Prof Dr Octavian Fodor Regional Institute Of Gastroenterology And Hepatology | Szabo B.,UMF Iuliu Hatieganu | Szabo B.,Clinical Emergency Hospital Cluj | And 5 more authors.
Drug Metabolism Reviews | Year: 2016

Colorectal cancer is a major public health issue, being the third most common cancer in men and the second in women. It is one of the leading causes of cancer deaths. Nanomedicine is an emerging field of interest, many of its aspects being linked to cancer research. Chemotherapy has a well-established role in colorectal cancer management, unfortunately being limited by inability to have a selective distribution, by multidrug resistance and adverse effects. Researches carried out in recent years about nanotechnologies aimed, among others, to resolve the issues mentioned above. Targeted and localized delivery of the chemotherapeutic drugs, using nanoparticles, with selective destruction of cancerous cells would minimize the toxicity on healthy tissues. Also, the use of nanomaterials as contrast agent could improve sensitivity and specificity of diagnosis. The purpose of this review is to highlight the recent achievements of cancer research by use of nanomaterials, in the idea of finding the ideal composite, capable to simultaneous diagnostic and treat cancer. © 2016 Taylor & Francis.


Cavasi A.,University of Medicine and Pharmacy, Cluj-Napoca | Cavasi A.,Prof Dr Octavian Fodor Regional Institute Of Gastroenterology And Hepatology | Mercea V.,University of Medicine and Pharmacy, Cluj-Napoca | Mercea V.,Prof Dr Octavian Fodor Regional Institute Of Gastroenterology And Hepatology | And 3 more authors.
Journal of Gastrointestinal and Liver Diseases | Year: 2016

Although transjugular intrahepatic portosystemic shunts are most frequently used for the management of portal hypertension, the surgical approach is preferred for symptomatic portal cavernoma cholangiopathy. We present the case of a 25-year old female patient with a portal cavernoma secondary to catheterization of the umbilical vein at birth. She had had two episodes of esophageal variceal bleeding, successfully treated by endoscopic banding. and an episode of acute cholangitis secondary to portal cavernoma cholangiopathy. Endoscopic sphincterotomy and biliary stenting were performed, and were followed by repeated episodes of biliary stent occlusion. The last biliary drainage procedure triggered a massive hemobilia. Since endoscopic therapy was ineffective, a surgical mesocaval shunt with graft interposition and splenectomy was performed with favorable outcome. In selected cases, the mesocaval shunting plays an essential role in the treatment of portal cavernoma cholangiopathy even in the era of interventional radiology. © 2016, Romanian Society of Gastroenterology. All rights reserved.


Ionescu D.,University of Medicine and Pharmacy, Cluj-Napoca | Ionescu D.,Outcome Research Consortium | Tibre C.,Prof Dr Octavian Fodor Regional Institute Of Gastroenterology And Hepatology
Nutritional Therapy and Metabolism | Year: 2013

Malnutrition in surgical cancer patients is an important preoperative condition that may worsen postoperative outcome and generates nutrition-related complications. The reported incidence of malnutrition in these patients is generally high, between 30% and 50%. The tests for nutritional status assessment most closely correlated with surgical outcome and postoperative complications should be chosen for preoperative assessment; these should be part of a protocol and also include perioperative nutritional interventions. The most commonly used tests for nutritional assessment along with the incidence and role of hypoalbuminemia in the preoperative evaluation are discussed, as well as postoperative nutrition-related complications. © 2013 SINPE-GASAPE.


PubMed | UMF Iuliu Hatieganu, Prof Dr Octavian Fodor Regional Institute Of Gastroenterology And Hepatology, Clinical Emergency Hospital and Clinical Emergency Hospital Cluj
Type: Journal Article | Journal: Drug metabolism reviews | Year: 2016

Colorectal cancer is a major public health issue, being the third most common cancer in men and the second in women. It is one of the leading causes of cancer deaths. Nanomedicine is an emerging field of interest, many of its aspects being linked to cancer research. Chemotherapy has a well-established role in colorectal cancer management, unfortunately being limited by inability to have a selective distribution, by multidrug resistance and adverse effects. Researches carried out in recent years about nanotechnologies aimed, among others, to resolve the issues mentioned above. Targeted and localized delivery of the chemotherapeutic drugs, using nanoparticles, with selective destruction of cancerous cells would minimize the toxicity on healthy tissues. Also, the use of nanomaterials as contrast agent could improve sensitivity and specificity of diagnosis. The purpose of this review is to highlight the recent achievements of cancer research by use of nanomaterials, in the idea of finding the ideal composite, capable to simultaneous diagnostic and treat cancer.


PubMed | Prof Dr Octavian Fodor Regional Institute Of Gastroenterology And Hepatology
Type: Journal Article | Journal: Clujul medical (1957) | Year: 2015

The aim of this study was to monitor the risk factors that trigger variceal bleeding in cirrhotic patients, assess the severity of the bleeding and the efficacy of the endoscopic hemostasis techniques, as well as the recurrence of bleeding episodes and the mortality rate.The current study was a prospective one, and it was conducted in the period November 2004 - December 2006 in the O. Fodor Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca. It included 273 patients with upper gastrointestinal bleeding because of variceal rupture, assessed by emergency endoscopy. The patients included in the study met the clinical, biochemical, endoscopic and ultrasound criteria for liver cirrhosis. Its etiology and staging were documented from the patients observation charts.Out of the 273 cases of variceal bleeding there were 255 (93.4%) cases of bleeding from esophageal varices and 18 (6.6%) from gastric varices. Variceal bleeding episodes were more frequent in patients with alcoholic liver cirrhosis (51.28%). Most patients with variceal bleeding were in Child class B or C (77%). Mortality because of variceal hemorrhage was 2.93% in the study group. A number of 148 patients were treated by sclerotherapy and 125 patients with elastic ligatures. Bleeding relapses occurred in 65 (23.8%) patients within the study group, 43 men and 22 women. Variceal bleeding relapses were more frequent after sclerotherapy than after elastic ligatures.Variceal bleeding occurred more frequently in patients with alcoholic cirrhosis stage Child C. In the current study mortality was relatively low. The treatment of bleeding recurrence is more difficult, hence variceal rupture prevention and application of elastic ligatures represent a therapeutic necessity.


PubMed | University of Medicine and Pharmacy, Cluj-Napoca and Prof Dr Octavian Fodor Regional Institute Of Gastroenterology And Hepatology
Type: Journal Article | Journal: Clujul medical (1957) | Year: 2015

Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder, affecting about 10 to 20% of the population in developed countries. The mechanisms underlying the symptoms of this condition are poorly understood. Considered initially as the consequence of abnormal gut motility, visceral hypersensitivity, psychosocial factors and brain-gut axis dysfunction, IBS is now acknowledged as a multifactorial disorder. Specific peripheral mechanisms are involved, including mucosal immune activation, increased intestinal permeability, entero-endocrine cell products, an excess of bile acids, gut dysbiosis. A better understanding of these mechanisms could help develop new and specific therapeutic pathways in patients suffering from IBS.


PubMed | University of Medicine and Pharmacy, Cluj-Napoca and Prof Dr Octavian Fodor Regional Institute Of Gastroenterology And Hepatology
Type: Journal Article | Journal: Journal of gastrointestinal and liver diseases : JGLD | Year: 2016

Endoscopic ultrasonography (EUS) and EUS-guided fine-needle aspiration (EUS-FNA) are considered good tools for the diagnosis of pancreatic cancer and for obtaining material for cytology or histology. The accuracy of EUS-FNA can rise to 85-95%, but it is lower in cases with a chronic pancreatitis background or with previous biliary stenting. We aimed to establish the diagnostic yield of the visible length of the core biopsy samples in pancreatic cancer by using one single type of standard 22G needle and to evaluate the factors which can influence the results.EUS-FNA was performed by using a 22G standard needle on patients prospectively recruited with the suspicion of pancreatic masses on transabdominal ultrasound or CT scan over a period of eight months. The number of passes was limited by the length of the core obtained. The final diagnosis was based on EUS-FNA or hepatic biopsy for their metastasis or by follow up every three month by imaging methods.The study included 118 patients. Previous stents were present in 10 patients and chronic pancreatitis features were found in 3 patients. The procedure sensitivity was 89% and the global accuracy was 89%. The presence of biliary stents did not impede the accuracy of results. The number of passes did not influence the results.The diagnostic rate of core biopsy by using 22G needles had a high accuracy and it is safe when the length of core dictates the number of passes. The presence of biliary stents did not influence the results.

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