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Okutucu S.,Memorial Ankara Hospital | Karakulak U.N.,Occupational Diseases Hospital | Aksoy H.,Memorial Ankara Hospital | Sabanoglu C.,Kirikkale High Speciality Hospital | And 8 more authors.
Cardiology Journal | Year: 2016

Background: Ventricular arrhythmias can be seen in systemic sclerosis (SSc) patients and are thought to be a result of fibrosis or ischemia of the ventricular myocardium. Tp-e interval and Tp-e/QT ratio are electrocardiographic (ECG) indices to predict ventricular tachyarrhythmia and cardiovascular mortality. We aimed to evaluate Tp-e interval and Tp-e/QT ratio in patients with SSc. Methods: A total of 107 patients with SSc (mean age, 48.6 ± 14.0 years; 96 females) and 100 healthy controls (mean age, 49.4 ± 8.6 years; 90 females) were enrolled. The standard 12-lead ECG was recorded; QTc, Tp-e interval and Tp-e/QT ratio were measured. Modified Rodnan skin severity score (MR-SSS) calculated for all SSc patients. Results: Tp-e interval (90.7 ± 23.8 ms vs. 84.0 ± 20.6 ms, p = 0.032) and Tp-e/QT ratio (0.20 ± 0.05 vs. 0.18 ± 0.04, p = 0.007, respectively) were significantly prolonged in SSc patients than in the control group. Pearson’s correlation analyses revealed positive correlations of MR-SSS with QTc (r = 0.427, p = 0.001), Tp-e interval (r = 0.620, p = 0.001) and Tp-e/ /QT ratio (r = 0.615, p = 0.001). MR-SSS (b = 2.108, p = 0.001) and CRP (b = 2.273, p = 0.027) were found to be significant independent predictors of Tp-e interval. Similarly, MR-SSS (b = 0.004, p = 0.001) was only a significant independent predictor of Tp-e/QT ratio among patients with SSc. Conclusions: The patients with SSc had a prolonged Tp-e interval and Tp-e/QT ratio compared with normal subjects. Furthermore, this prolongation was well correlated with clinical severity score among patients with SSc. Ventricular repolarization dispersion as a predictor of ventricular arrhythmias was found to be diminished in patients with SSc. Patients with SSc, particularly with higher MR-SSS, should be followed closely for adverse cardiovascular outcomes. © 2016 Via Medica. Source


Yoldas O.,Ordu State Hospital | Tez M.,Ankara Numune Teaching and Research Hospital | Karaca T.,Occupational Diseases Hospital
American Journal of Emergency Medicine | Year: 2012

The aim of the study was to assess the role of artificial neural networks in the diagnosis of acute appendicitis in patients presenting with right lower abdominal pain. Data from 156 patients presenting with suspected appendicitis over a 12-month period to a rural hospital were collected prospectively. The sensitivity, specificity, and positive and negative predictive values of the artificial neural network were 100%, 97.2%, 96.0%, and 100% respectively. Artificial neural networks can be an effective tool for accurately diagnosing acute appendicitis and may reduce unnecessary appendectomies. © 2012 Elsevier Inc. All rights reserved. Source


Hidiroglu S.,Marmara University | Tanriover O.,Yeditepe University | Unaldi S.,Occupational Diseases Hospital | Sulun S.,Health Directorate | Karavus M.,Marmara University
Journal of the Pakistan Medical Association | Year: 2013

Objective: To determine the frequency and pattern of energy drink consumption among medical school students, their knowledge of its effects and side effects and to see its relation with alcohol and cigarette usage. Method: The descriptive analytical study was conducted at Marmara University Medical School, Istanbul, Turkey from October 2011 and January 2012. A semi-structured questionnaire was filled by students who were asked about their socio-demographic status and their energy drink consumption. SPSS 12 was used for statistical analysis. Results: The mean age of the 390 students in the study was 20.98±1.96 years (range:16-27). Of them, 204 (52.3%) were females and 186 (47.7%) were males. Overall 52(13.3%) were smoking regularly at least one cigarette per day; 122(31.3%) were consuming alcohol; 127 (32.6%) had consumed energy drinks at least once and 73(18.8%)more than once. In terms of perception, 110(28.2%) students said energy drinks were similar to sports drinks, while only 121(41.1%) named the brands correctly; 96 (24.6%) students did not answer this particular question. Conclusion: Although consumption of energy drinks was common among medical students, the knowledge of ingredients and knowledge of health risks of energy drinks among them was unsatisfactory. Source


Findik R.B.,Zekai Tahir Burak Education and Research Hospital | Celik H.T.,Ankara University | Yilmaz F.M.,Ankara Numune Education and Research Hospital | Yilmaz H.,Occupational Diseases Hospital | Abusoglu S.,Selcuk University
Journal of Clinical and Analytical Medicine | Year: 2016

Aim: Assymetric dimethylarginin (ADMA), an inhibitor of nitric oxide synthase (NOS), has been linked to endothelial dysfunction. Our aim in this study was to compare ADMA and arginine levels in normal glucose tolerance, impaired glucose tolerance and gestational diabetes groups and investigate the effect on baby birth weight. Material and Method: Serum ADMA and arginine levels were investigated in 64 patients whose 50-g glucose loading test was normal (group 1, NGT); 33 patients whose 50-g test result was high and those whose 100-g oral glucose tolerance test (OGTT) was normal, namely, those with impaired glucose tolerance (IGT, group 2); and in 8 patients diagnosed with gestational diabetes mellitus (GDM, group 3). Results: Arginine levels were significantly higher in the IGT group than in the NGT group. ADMA levels were high in the GDM group, but the difference was not statistically significant. There were a statistically significant correlation between arginine and ADMA levels and the ADMA level of those with a diabetes history. No significant relationship was found between ADMA level, arginine and the weight of the infant. Discussions: Although there has not been a clinical status related with nitric oxide deficiency caused by increasing ADMA concentrations, pregnancies with increased body mass indeks (BMI), family history for diabetes and older ages should be carefully monitorized. ADMA tends to increase in patients with IGT and GDM. In addition, blood ADMA and arginine levels do not seem to influence the weight of the infant. © 2016, Journal of Clinical and Analytical Medicine. All rights reserved. Source


Akbal E.,Canakkale Onsekiz Mart University | Koklu S.,Hacettepe University | Astarci H.M.,Ankara Education and Research Hospital | Kocak E.,Ankara Education and Research Hospital | And 6 more authors.
International Journal of Medical Sciences | Year: 2013

Background and aims: Ankaferd Blood Stopper (ABS) is a herbal extract obtained from five different plants. It has a therapeutic potential for the management of external hemorrhage and controlling gastrointestinal bleeding. However, ABS's effects are not unknown on gastrointestinal systems. The aim of this study was to assess the effect of short- and long-term systemic exposure and gastrointestinal safety following the oral administration of high-dose ABS in rats. Methods: Eighteen healthy adult male rats were included into the study. The rats were divided into 4 groups: group A was fed with high dose ABS (2ml/Kg) for one week, group B for one month, group C for three months and group D's diet did not contain any ABS. On termination of the ABS treatment, the gastrointestinal system from the esophagus to the anus and the liver were surgically removed and histological investigated. Results: During the study period, there was no mortality; signs of intoxication in any of the studied groups. No gastrointestinal tissue fibrosis, dysplasia, or metaplasia was detectable in any of the groups. The stomach had a normal morphology in all groups. However, the other gastrointestinal tract sections showed mucosal inflammation, goblet cell decrements, and intra-epithelial lymphocyte infiltration. The most common changes were mucosal inflammation in all rats in group B and C. Frequency of inflammation was greater in groups B and C in comparison to group A (P= 0.001). Loss of goblet cell and intra-epithelial lymphocyte infiltration were not significantly different between groups A and B (P=0.308 and P=0.189, respectively). However, there was significantly higher intra-epithelial lymphocyte infiltration in group C than in group A (P=0.04). Histopathological examination of the liver showed no inflammation, fibrosis, bile duct destruction or proliferation in any of the groups. However, each groups revealed vascular dilatation and erythrocyte accumulation at the sinusoidal structures of the liver. Conclusions: ABS seems to be a safe agent and it can be used for hemorrhage originated from gastric lesions. Further work needs to be done to establish whether ABS leads to be used to stop gastrointestinal bleeding. © Ivyspring International Publisher. Source

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