Obninsk Institute of Atomic Power Engineering

Obninsk, Russia

Obninsk Institute of Atomic Power Engineering

Obninsk, Russia
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Stepanov V.A.,Obninsk Institute of Atomic Power Engineering | Khmelevskaya V.S.,Obninsk Institute of Atomic Power Engineering | Bogdanov N.Yu.,Obninsk Institute of Atomic Power Engineering | Gorchakov K.A.,Obninsk Institute of Atomic Power Engineering
Russian Journal of Physical Chemistry A | Year: 2011

The relationship between the structural state of adsorbed water, the crystal structure of the substances, and the solubility of the perindopril salt C 19H 32N 2O 5 · C4H11N in water was studied by IR spectroscopy and X-ray diffractometry. The high-frequency shift of the stretching vibrations of adsorbed water and the solubility depend on the crystal structure of the drug substance. A reversible chemical reaction occurred between the adsorbed water and the perindopril salt. nds, structural polymorphism, dissolution. © 2011.Pleiades Publishing, Ltd.

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