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Urbana, IL, United States

Lee W.,Chosun University | Snyder S.E.,University of Illinois at Urbana - Champaign | Volkers P.I.,University of Illinois at Urbana - Champaign | Pirkle W.H.,University of Illinois at Urbana - Champaign | And 5 more authors.
Tetrahedron | Year: 2011

Chiral stationary phases were synthesized and their ability to separate racemic precursors from which they were derived was assessed. Taken in conjunction with homochiral recognition previously observed in the solid state, the results of this study reveal that a geometrically controlling π-π interaction has a profound influence on molecular recognition. © 2011 Elsevier Ltd. All rights reserved. Source


Zeng C.-M.,Obiter Research | Kerrigan S.A.,Obiter Research | Katzenellenbogen J.A.,University of Illinois at Urbana - Champaign | Slocum C.,Radius Health Inc. | And 5 more authors.
Tetrahedron Letters | Year: 2010

An efficient synthesis of the non-proteinogenic amino acid (2R,3S)-4,4,4-trifluoro(OBn)-threonine is described. Starting with commercially available (S)-Garner's aldehyde, the desired amino acid was prepared as its hydrochloride salt in five steps and an overall yield of 33% (59% based on recovered starting material). The utility of this unusual amino acid was demonstrated by its elaboration into a potent and selective androgen. © 2010 Elsevier Ltd. All rights reserved. Source


Miller C.P.,Radius Health Inc. | Shomali M.,Radius Health Inc. | Lyttle C.R.,Radius Health Inc. | O'dea L.S.L.,Radius Health Inc. | And 12 more authors.
ACS Medicinal Chemistry Letters | Year: 2011

This report describes the discovery of RAD140, a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). The characterization of RAD140 in several preclinical models of anabolic androgen action is also described. © 2010 American Chemical Society. Source

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