Obafemi Awolowo University

Ife, Nigeria

Obafemi Awolowo University is a federal government owned and operated Nigerian university. The university is in the ancient city of Ile-Ife, Osun State, Nigeria. The university was founded in 1961 and classes commenced in October 1962 as the University of Ife by the regional government of Western Nigeria, led by late chief Samuel Ladoke Akintola, and was renamed Obafemi Awolowo University on 12 May 1987 in honour of Chief Obafemi Awolowo , first premier of the Western Region of Nigeria, whose brainchild the university was. Wikipedia.

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NEW YORK, May 01, 2017 (GLOBE NEWSWIRE) -- Anavex Life Sciences Corp. (“Anavex” or the “Company”) (Nasdaq:AVXL), a clinical-stage biopharmaceutical company developing differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental diseases including Alzheimer’s disease, other central nervous system (CNS) diseases, pain and various types of cancer, today announced the appointment of Emmanuel O. Fadiran, RPh, PhD, as Senior Vice President of Regulatory Affairs. Dr. Fadiran has 24 years of regulatory experience within the U.S. Food and Drug Administration (FDA), having held leadership positions at the FDA’s Center for Drug Evaluation and Research (CDER). “Dr. Fadiran has an accomplished track record of working within the FDA,” said Christopher U. Missling, PhD, President and Chief Executive Officer of Anavex. “His depth of experience makes him an excellent choice to manage the considerable number of regulatory filings that Anavex has planned.” Prior to joining Anavex, Dr. Fadiran served as a Clinical Pharmacology Team Leader at the FDA’s CDER. During his 24-year (1993-2017) tenure at the FDA, Dr. Fadiran reviewed hundreds of New Drug Applications (NDAs), supplemental New Drug Applications (sNDAs), Biologics License Application (BLAs), Abbreviated New Drug Applications (ANDAs) and Investigational New Drug applications (INDs) for approval and made strategic recommendations for the development of several products across many therapeutic categories.  He was on review teams for several novel therapies including first-in-class approvals. Dr. Fadiran also led a cross-disciplinary NDA review team and authored the first Cross-Discipline Team Leader (CDTL) review for the Division of the Pulmonary and Allergy Products, Office of Drug Evaluation II, CDER. He was actively involved in the writing, internal/external training and implementation of the U.S. FDA Guidance for Industry for population pharmacokinetics. “I am very pleased to be joining Anavex at this important and exciting time for the company,” stated Dr. Fadiran. “There are tremendous opportunities ahead, and I look forward to working with the Anavex team to deliver on the corporate objectives for 2017 and beyond.” Dr. Fadiran has been involved in the formulation of significant strategic FDA regulatory initiatives including serving as a member of the Senior Management Teams for the Data Standard (Janus) and Sentinel Initiatives. He was an active member of the FDA Senior Science Council working group for the creation and launching of the FDA’s Strategic Plan for Regulatory Science in 2012. Recently, he has played an active role in the development of the Comprehensive in vitro Proarrhythmia Assay (CiPA) for future replacement of the thorough QT studies. As a long-term member of the FDA Institutional Review Board (IRB), he actively contributed to the development of standard operating procedures (SOP) for the committee. Dr. Fadiran holds a BS (Pharmacy) and MS from Obafemi Awolowo University, Ile-Ife, Nigeria and a PhD in Pharmaceutical Sciences from the University of Strathclyde, Glasgow, UK.  Dr. Fadiran is a recipient of the prestigious Fogarty International Fellowship of the National Institutes of Health (NIH) (1991-1993) as well as numerous awards from the FDA, among them the Commissioner’s Award of Excellence, in recognition of his outstanding contributions to regulatory review of applications and development of regulatory guidance and policies. About Anavex Life Sciences Corp. Anavex Life Sciences Corp. (Nasdaq:AVXL) is a publicly traded biopharmaceutical company dedicated to the development of differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental diseases including Alzheimer’s disease, other central nervous system (CNS) diseases, pain and various types of cancer. Anavex’s lead drug candidate, ANAVEX 2-73, recently successfully completed a Phase 2a clinical trial for Alzheimer’s disease. ANAVEX 2-73 is an orally available drug candidate that restores cellular homeostasis by targeting sigma-1 and muscarinic receptors and successfully completed Phase 1. Preclinical studies demonstrated its potential to halt and/or reverse the course of Alzheimer’s disease. ANAVEX 2-73 has also exhibited anticonvulsant, anti-amnesic, neuroprotective and anti-depressant properties in animal models, indicating its potential to treat additional CNS disorders, including epilepsy and others. The Michael J. Fox Foundation for Parkinson’s Research has awarded Anavex a research grant to develop ANAVEX 2-73 for the treatment of Parkinson’s disease to fully fund a preclinical study, which could justify moving ANAVEX 2-73 into a Parkinson’s disease clinical trial. ANAVEX 3-71, also targeting sigma-1 and M1 muscarinic receptors, is a promising preclinical drug candidate demonstrating disease modifications against the major Alzheimer’s hallmarks in transgenic (3xTg-AD) mice, including cognitive deficits, amyloid and tau pathologies, and also with beneficial effects on neuroinflammation and mitochondrial dysfunctions. Further information is available at www.anavex.com. You can also connect with the company on Twitter, Facebook and LinkedIn. Forward-Looking Statements Statements in this press release that are not strictly historical in nature are forward-looking statements. These statements are only predictions based on current information and expectations and involve a number of risks and uncertainties. Actual events or results may differ materially from those projected in any of such statements due to various factors, including the risks set forth in the Company’s most recent Annual Report on Form 10-K filed with the SEC. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement and Anavex Life Sciences Corp. undertakes no obligation to revise or update this press release to reflect events or circumstances after the date hereof.

News Article | May 4, 2017
Site: www.theengineer.co.uk

A team from Surrey University has been shortlisted for the finals of Airbus’ Fly Your Ideas challenge, a biennial global student competition with a top prize of €30,000. Surrey’s Team SkyVision propose turning a commercial airliner into an ‘Earth Observation Device’ by installing equipment into the belly of the aircraft to monitor ground activity during flight, thereby providing an alternative to satellite imagery. Other concepts to make the finals include a method to improve aircraft taxiing, new ways of boarding via an app, new areas for luggage storage, and a new business model using existing Airbus aircraft. The finalists represent nine different nationalities and eight universities across Africa, Europe and Asia-Pacific, and are drawn from disciplines that include engineering, natural sciences and business. Their ideas were selected from over 350 entries in Airbus’ competition, run in partnership with UNESCO. Students’ ideas had to answer one of five challenges identified by Airbus to provide sustainable future solutions. The five finalist teams – from Australia, France, Hong Kong, Nigeria and the UK – will soon travel to Toulouse, France, where they will spend a week at the Airbus ProtoSpace facility to prototype, test and visualise their ideas using advanced equipment with personal guidance from Airbus. At the end of their week at Airbus, the students will present their projects and the newly developed prototype in front of Airbus experts and personalities from the aerospace and academic world. The final will take place on 17th May in Toulouse. The ideas competing for the final prize are: Airborne Earth Observation – Team SkyVision, University of Surrey, UK A concept that turns a commercial airliner into an ‘Earth Observation Device’ by installing equipment into the underside of an aircraft to monitor ground activity during flight. An alternative to satellite imagery, it opens up new opportunities such as ecology analysis and urban planning. Improving Airport Taxi Flow and Efficiency – Team Nevada, Obafemi Awolowo University, Nigeria An airport taxiing system that uses sensors and algorithms for automated Ground Traffic Control, both in the tower and on the aircraft, to improve aircraft traffic at airports and thus reduce emissions. Compact Luggage Strategy Mobile App – Team PassEx, Institut d’Administration des Entreprises – IAE Toulouse, France A boarding system that uses a real-time mobile app to assign boarding status to passengers according to their luggage size. The Compact Luggage Strategy (CLS) addresses current storage issues in over-head compartments by distributing passengers across the aircraft according to the size of their baggage. Private Stowage Compartment – Team DAELead, The University of Hong Kong, Hong Kong An aircraft cabin design that locates a Private Stowage Compartment (PSC) underneath passengers’ feet, utilizing the space between the cabin floor and the cargo ceiling. A400M Aerial Firefighting Platform – Team Aquarius, Royal Melbourne Institute of Technology, Australia A fire-fighting solution that incorporates modular systems using pressurised fire retardant containers fixed to fast-loadable pallets for a network of Airbus A400M aircraft, to create a system of aerial firefighting platforms that can be used for rapid wildfire suppression.

Ayanlade A.,Obafemi Awolowo University
International Journal of Image and Data Fusion | Year: 2017

Selection of appropriate data and methods for environmental change assessment is highly central in any remote sensing research project. This study assessed various land use/land cover change (LUCC) methods and tested the accuracy of prominent classification methods and their implications on land surface temperature (LST) change estimation. Niger Delta of Nigeria was used as a case study. The study concluded that, though no single method can be applied to all cases and regions, there are some factors that determine the remote sensing methods to be used in both LST and LUCC change analysis. Such factors include the spatial, temporal, spectral and radiometric resolutions of satellite image and environmental factors. Therefore, this paper evaluated methods used in earlier studies to assess, monitor and model LUCC impacts on LST. The paper concludes by proposing the use of two or more methods in any LUCC–LST research project. This is because, all remote sensing methods are not totally right, but some are useful, thus, the methods should be viewed as complementary. © 2017 Informa UK Limited, trading as Taylor & Francis Group

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ENV.2013.6.1-2 | Award Amount: 11.51M | Year: 2013

Massive economic and population growth and urbanisation are expected to lead to a tripling of anthropogenic emissions in southern West Africa (SWA) between 2000 and 2030, the impacts of which on human health, ecosystems, food security and the regional climate are largely unknown. An assessment of these impacts is complicated by (a) a superposition with effects of global climate change, (b) the strong dependence of SWA on the sensitive West African monsoon, (c) incomplete scientific understanding of interactions between emissions, clouds, radiation, precipitation and regional circulations and (d) by a lack of observations to advance our understanding and improve predictions. The DACCIWA project will conduct extensive fieldwork in SWA to collect high-quality observations, spanning the entire process chain from surface-based natural and anthropogenic emissions to impacts on health, ecosystems and climate. Combining the resulting benchmark dataset with a wide range of modelling activities will allow (a) to assess all relevant physical and chemical processes, (b) to improve the monitoring of climate and compositional parameters from space and (c) to develop the next generation of weather and climate models capable of representing coupled cloud-aerosol interactions, which will ultimately lead to reduced uncertainties in climate predictions. SWA with its rich mix of emissions and diverse clouds is ideal for such a study and many findings and technical developments will be applicable to other monsoon regions. Using a targeted dissemination strategy, DACCIWA will deliver a comprehensive scientific assessment and actively guide sustainable future planning and policy-making for West Africa and beyond. The interdisciplinary and experienced DACCIWA team will build on the scientific and logistical foundations established by AMMA (EU FP6) and collaborate closely with operational centres, international programs (e.g. WCRP, IGBP), policy-makers and users to maximise impact.

Adunola A.O.,Obafemi Awolowo University
Building and Environment | Year: 2014

A thermal comfort survey was conducted in Ibadan metropolis, Nigeria. Ten percent (12) of the 119 neighbourhoods identified from the metropolitan map were selected by stratified random sampling comprising 2 low, 3 medium and 7 high residential densities. Systematic random sampling was used to select a total of 528 houses within these neighbourhoods for the survey. Indoor and outdoor measurements of air temperature and other relevant climatic elements were carried out in representative buildings within the neighbourhoods. For each selected building, an adult resident filled a questionnaire indicating the indoor thermal response at different periods of the day using the ASHRAE thermal comfort scale. Significant variations of air temperature and thermal response manifested across the residential densities and neighbourhoods. The air temperature variation across the neighbourhoods was found to be influenced by the different neighbourhood characteristics. Maximum values of measured outdoor and indoor temperatures ranged from 34.1°C to 36.9°C and from 32.5°C to 35°C respectively. The reduction in maximum temperatures from outdoor to indoor was in the range of 1.6-1.9°C. The variation of temperature across residential densities was found to affect indoor thermal comfort. It was inferred that the urban microclimate had impact on the indoor comfort of residents. Mean comfort vote was related to indoor and outdoor temperature by linear equations. © 2014 Elsevier Ltd.

Adesina S.K.,Obafemi Awolowo University
African journal of traditional, complementary, and alternative medicines : AJTCAM / African Networks on Ethnomedicines | Year: 2013

Mistletoes of the Loranthaceae and Viscaceae are hemiparasitic plants and their preparations in the form of injectable extracts, infusions, tinctures, fluid extracts or tea bags are widely used in various cultures in almost every continent to treat or manage various health problems including hypertension, diabetes mellitus, inflammatory conditions, irregular menstruations, menopause, epilepsy, arthritis, cancer, etc. The medicinal values of some species of Mistletoes (Loranthaceae) growing in the West African sub-region have been reviewed along with some considerations of their chemistries and local uses. These have been compared with Mistletoes (Loranthaceae and Viscaceae) growing elsewhere in Europe and Asia. This review has attempted to update our knowledge on the values of these hemi-parasites which belong to the genera - Globimetula, Phragmanthera, Agelanthus and Tapinanthus, and which have, for years, been seen as only devastating and notorious plants. They are also seen as epiphyting economic, ornamental and medicinal plants. The hemi-parasitic plants (Mistletoes) are not well understood as very little is known about their biology (taxonomy, host/plant relationship, ecology, toxicology, physiological characteristics, etc.) and chemistry (chemical constituents' profile). Some pharmacological studies carried out on the various crude alcoholic extracts and purified fractions have, however, revealed that mistletoes showed hypotensive, hypoglycaemic, antilipidaemic, anti-oxidative, anti-inflammatory, antimicrobial, etc. effects and were non-toxic in experimental animals at the doses used. The findings showed that mistletoes can be very useful as medicinal agents in ameliorating health problems such as diabetes mellitus, hypertension, arthritis, pain, cancer and a host of other ailments if properly studied and developed.

Afon A.,Obafemi Awolowo University
Waste Management and Research | Year: 2012

This study presents the social, economic, health and environmental implications of solid waste scavenging activity in Olusosun, one of the government's designated open waste dumpsites in Lagos, Nigeria. Using incidental or convenience sampling methods of questionnaire administration, 112 scavengers were sampled. It was established that scavenging on the site was only possible through registration with an associate on site. Recovering items from hills of waste involved physical energy and the use of manually-operated rudimentary equipment. Thus, 87% of the scavengers were males in their early twenties (minimum age = 19 years; maximum age = 35 years; mean = 26.7 years; SD = 4.2). The daily mean income from the exercise was Naira480.80 (Naira160 = $1.00). The most important method of arriving at the selling prices of the scavenged products was the use of scale measurement. Although the scavengers were aware that scavenging exposed them to both environmental and health hazards, they continued scavenging for economic and social reasons. The study concluded that because of the level of employment provided and the large number of people directly involved (1243 on this site alone), outright banning, even when the open dump is closed down, without rehabilitating the scavengers will constitute a social, economic and security threat to the community. Scavenging should, therefore, be integrated fully into the waste-management system and regulated. © The Author(s) 2012.

Betiku E.,Obafemi Awolowo University | Taiwo A.E.,Obafemi Awolowo University
Renewable Energy | Year: 2015

This study investigated the use of Breadfruit Starch Hydrolysate (BFSH) as the sole carbon source for bioethanol production and the optimization of the fermentation parameters. The results showed that the yeast was able to utilize the BFSH with and without nutrient supplements, with highest bioethanol yield of 3.96 and 3.60% volume fraction, respectively after 24h of fermentation. A statistically significant quadratic regression model (p<0.05) was obtained for bioethanol yield prediction. Response Surface Methodology (RSM) optimal condition values established for the bioethanol yield were BFSH concentration of 134.81gL-1, time of 21.33h and pH of 5.01 with predicted bioethanol yield of 3.95% volume fraction. Using Artificial Neural Network (ANN), multilayer normal feedforward incremental back propagation with hyperbolic tangent function gave the best performance as a predictive model for bioethanol yield. ANN optimal condition values were BFSH concentration of 120gL-1, time of 24h and pH of 4.5 with predicted bioethanol yield of 4.21% volume fraction. The predicted bioethanol yield was validated experimentally as 4.10% volume fraction and 4.22% volume fraction for RSM and ANN, respectively. Coefficient of Determination (R2) and Absolute Average Deviation (AAD) were determined as 1 and 0.09% for ANN and 0.9882 and 1.67% for RSM, respectively. Thus, confirming ANN was better than RSM in both data fittings and estimation capabilities. © 2014 Elsevier Ltd.

Adeyemi D.O.,Obafemi Awolowo University
BMC complementary and alternative medicine | Year: 2014

Flavonoid-rich aqueous fraction of methanolic extract of Hibiscus sabdariffa calyx was evaluated for its anti-hepatotoxic activities in streptozotocin-induced diabetic Wistar rats. Diabetes Mellitus was induced in Wistar rats by a single i.p injection of 80 mg/kg b.w. streptozotocin (STZ) dissolved in 0.1 M citrate buffer (pH 6.3). The ameliorative effects of the extract on STZ-diabetes induced liver damage was evident from the histopathological analysis and the biochemical parameters evaluated in the serum and liver homogenates. Reduced levels of glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) (3.76 ± 0.38 μM, 0.42 ± 0.04 U/L, 41.08 ± 3.04 U/ml, 0.82 ± 0.04 U/L respectively) in the liver of diabetic rats were restored to a near normal level in the Hibiscus sabdariffa-treated rats (6.87 ± 0.51 μM, 0.72 ± 0.06 U/L, 87.92 ± 5.26 U/ml, 1.37 ± 0.06 U/L respectively). Elevated levels of aspartate amino transferase (AST), alanine amino transferase (ALT) and alkaline phosphatase (ALP) in the serum of diabetic rats were also restored in Hibiscus sabdariffa -treated rats. Examination of stained liver sections revealed hepatic fibrosis and excessive glycogen deposition in the diabetic rats. These pathological changes were ameliorated in the extract-treated rats. The anti-hepatotoxic activity of Hibiscus sabdariffa extract in STZ diabetic rats could be partly related to its antioxidant activity and the presence of flavonnoids.

News Article | February 23, 2017
Site: www.prweb.com

In Bukky Agboola’s new book, I Made It Through ($15.49, paperback, 9781498472142; $7.99, eBook, 9781498472159) readers will be blessed and inspired by the triumph of faith in God through Jesus Christ. Journey with Bukky from Nigeria, to California. When God’s word is believed, trusted in, and obeyed, the human spirit can endure and come through a myriad of trials. Readers will learn faith principles that have turned many lives around in this moving account. Agboola says, “The blessing of God’s amazing prophetic calling upon my life. Friendship with two of Gospel music’s most legendary names, the late Pastor Andrae Crouch and his sister Sandra, and the very special privilege of being acknowledged by the Vice President of the Federal Republic of Nigeria Professor Yemi Osinbajo, all make my journey a very unique one. In 1993 I headlined a memorable Gospel Concert at the London City Temple with the Rev Bazil Meade and The London Community Gospel Choir, one of England's most successful gospel choirs. This choir's credits include Royal performances for her Majesty the Queen.” Bukky Agboola has been blessed to be an ordained Minister of the Gospel of our Lord Jesus Christ for over two decades, and released four gospel albums, two of which were sold out during her tours all over Nigeria and the United Kingdom. A graduate of one of Africa's top Universities, The University of Ife, now known as Obafemi Awolowo University, in Ile Ife, Oyo state, Nigeria and Award winner at the Coulsdon and Purley Music Festival in England. Xulon Press, a division of Salem Media Group, is the world’s largest Christian self-publisher, with more than 12,000 titles published to date. Retailers may order I Made it Through through Ingram Book Company and/or Spring Arbor Book Distributors. The book is available online through xulonpress.com/bookstore, amazon.com, and barnesandnoble.com.

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