VANCOUVER, WA, United States
VANCOUVER, WA, United States

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Patent
Oasis Diagnostics Corporation | Date: 2015-07-20

A sample collection system includes a sample collector having a handle with a collection strip retainer and male threaded portion disposed around the retainer, a collection strip extending from the retainer, wherein the collection strip has a pre-determined maximum load for the sample fluid and a sample volume adequacy indicator; a transport tube including a coupling to removably receive a transport tube cap and a female threaded portion to removably receive the sample collector male threaded portion, the transport tube including visually discernable graduated scale and being a translucent or transparent; and, a predetermined volume of buffer solution disposed within the transport tube cylinder. A method for collecting a fluid sample of adequate volume and known dilution factor is provided utilizing the sample collection system.


Ovchinnikov D.A.,University of Queensland | Cooper M.A.,University of Queensland | Pandit P.,University of Queensland | Coman W.B.,University of Queensland | And 5 more authors.
Translational Oncology | Year: 2012

Head and neck squamous cell carcinoma (HNSCC) accounts for a bulk of the oral and laryngeal cancers, the majority (70%) of which are associated with smoking and excessive drinking, major known risk factors for the development of HNSCC. In contrast to reports that suggest an inverse relationship between smoking and global DNA CpG methylation, hypermethylation of promoters of a number of geneswas detected in saliva collected frompatients with HNSCC. Using a sensitivemethylation-specific polymerase chain reaction (MSP) assay to determine specificmethylation events in the promoters of RASSF1A, DAPK1, and p16 genes, we demonstrate that we can detect tumor presence with an overall accuracy of 81% in the DNA isolated from saliva of patients with HNSCC (n = 143) when compared with the DNA isolated from the saliva of healthy nonsmoker controls (n = 31). The specificity for this MSP panel was 87% and the sensitivity was 80%(with a Fisher exact test P <.0001). In addition, the test panel performed extremely well in the detection of the early stages of HNSCCs, with a sensitivity of 94%and a specificity of 87%, and a high κ concordance value of 0.8, indicating an excellent overall agreement between the presence of HNSCC and a positive MSP panel result. In conclusion, we demonstrate that the promoter methylation of RASSF1A, DAPK1, andp16 MSP panel is useful in detecting hypermethylation events in a noninvasive manner in patients with HNSCC. © 2012 Neoplasia Press, Inc.


Patent
Oasis Diagnostics Corporation | Date: 2011-02-01

A biological sample collection system is described comprising a biological sample collecting wand and a buffer container with a buffer solution. The biological sample collecting wand includes a handle and a sample collector detachably coupled to the handle. The sample collector include one or more sample protrusions, one or more sample apertures, or a combination thereof, at least the sample collector to removably insert into the buffer container.


Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 325.57K | Year: 2011

DESCRIPTION (provided by applicant): This Phase 1 NIH SBIR proposal is for support of an interdisciplinary program involving the Oasis Diagnostics(R) Corporation, Madison Biodiagnostics, LLC, and the University of New Orleans who seek to collaboratively demonstrate an innovative saliva collection and analysis system (VerOFy(R)) for measurement of cortisol levels at the point of sampling for measurement of real time stress response in the clinical laboratory. The innovative VerOFy(R) Rapid, Oral Fluid TestPlatform (US PN 7,618,591) is an integrated sample collection and laboratory processing system that collects saliva by means of a proprietary absorbent pad connected to immunochromatographic test strips that produce a series of signal lines on the test strips correlating with varying cortisol levels in the acquired saliva sample within minutes of sample collection. Stress related research burgeoned to 22 million funded by NIH per year. Substantial research advancements were made after the stress hormone cortisol could be noninvasively measured in saliva. Salivary cortisol is arguably the most common biomarker used in a broad range of research protocols targeted at stress related illnesses. The present proposal pursues a significant advancement in stress research with the potential for advancing the field much like saliva testing did. Real time point of care cortisol measurement capability using the VerOFy(R) technology represents a substantial productivity improvement and cost reduction for stress responsiveness research. We estimate that between 30% and 50% of the 22 million expended for this research each year by NIH may produce little or questionable research benefit in current practice and would be potentially saved by use of the VerOFy(R) device. VerOFy(R) opens up new, unexplored possibilities within the stress research and related fields to tailor or individualize protocols for each individual including the rapid determination of stress non-responders. It further represents an opportunity for a standardized approach to cortisol measurements in stress related research. The cost and time benefits of this innovation will extend to 22 million of NIH funded research programs which rely upon the measurement of cortisol levels to identify stress responsiveness, bringing substantial cost reductions and productivity improvements to NIH funded stress related research. Phase 1 will demonstrate validation of the VerOFy(R) technology against standard control solutions of cortisol. Phase 2 of this program will demonstrate the effectiveness of this new method in improving research results and lowering the costs of stress related research. PUBLIC HEALTH RELEVANCE: NIH funds 22 million of stress related research which is dependent upon measurement of the biomarker cortisol as an indicator of stress response. Variation in current cortisol detection methods makes it impossible to individualize experimental protocols and compare results from different research programs. The present proposal uses an innovative salivary diagnostic device (VerOFy(R)) to standardize cortisol measurements and to lower stress related research costs.


Patent
Oasis Diagnostics Corporation | Date: 2014-06-12

Apparatus and methods are provided to obtain RNA-enhanced and protein-enhanced fluid samples which are stable at ambient temperatures. An apparatus includes a filter element made from a fibrous hydrophilic material which preferentially binds and filters cells, DNA-containing macrostructures, mucins and particulates, but does not preferentially bind RNA, RNA-containing macrostructures or proteins. An apparatus may include a sample collector having an absorbent collection pad which also does not preferentially bind RNA, RNA-containing macrostructures or proteins. A method includes obtaining a sample and passing the sample through an RNA-and-protein-preferential filter element to obtain RNA-enhanced and protein-enhanced samples. The method may include use of a RNA-and-protein-preferential absorbent pad material to collect the sample. DNA-rich samples may be obtained by using DNA elution buffer to release the DNA-containing cells and macrostructures after obtaining the RNA-enhanced and protein-enhanced samples.


Patent
Oasis Diagnostics Corporation | Date: 2014-11-10

A pediatric saliva collection system includes a pacifier portion, a stiffener, a collector, and a pad compression tube. The pacifier portion includes a receiver having a first interior cavity and nipple having a second interior cavity in fluid communication with the first interior cavity, the nipple including a plurality of apertures. The stiffener is insertable into the pacifier receiver, and adapted to receive the collector therein, the collector including a handle, an absorbent pad extending out from the handle and a seal; the collector removably insertable into the pacifier portion; and, the pad compression tube insertable over the collector to compress the absorbent pad and express liquid sample.


An apparatus for generating and collecting saliva samples containing enhanced cell concentrations includes a mouthpiece having a mouth contact portion and a flow channel which may include a tapered basin, a conduit in fluid communication with the flow channel, and one or more collectors couplable to the conduit. The mouth contact portion and basin may be textured to enhance cell removal. The mouth contact portion may include a plurality of internal and external channels disposed around the flow channel. Filters may be included between the flow channel and the collectors. A closure member is provided.


Trademark
Oasis Diagnostics Corporation | Date: 2014-03-03

Medical specimen collection device in the nature of absorbent pads, plastic tubes, absorbent pad holders for the collection of cervicovaginal cells.


Trademark
Oasis Diagnostics Corporation | Date: 2015-11-24

Medical specimen collection device in the nature of absorbent pads, plastic tubes, absorbent pad holders for the collection of cervicovaginal cells.


Trademark
Oasis Diagnostics Corporation | Date: 2011-01-04

Assays and reagents for use in genetic research; Reagent kits comprising generic DNA circle, DNA primers, polymerase and buffers for use in biotechnology fields.

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