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Thakore B.K.,Northwestern University | Naffziger-Hirsch M.E.,Oakton Community College | Richardson J.L.,University of Illinois at Chicago | Williams S.N.,Northwestern University | McGee R.,Northwestern University
BMC Medical Education | Year: 2014

Background: Approaches to training biomedical scientists have created a talented research community. However, they have failed to create a professional workforce that includes many racial and ethnic minorities and women in proportion to their representation in the population or in PhD training. This is particularly true at the faculty level. Explanations for the absence of diversity in faculty ranks can be found in social science theories that reveal processes by which individuals develop identities, experiences, and skills required to be seen as legitimate within the profession. Methods/Design. Using the social science theories of Communities of Practice, Social Cognitive Career Theory, identity formation, and cultural capital, we have developed and are testing a novel coaching-based model to address some of the limitations of previous diversity approaches. This coaching intervention (The Academy for Future Science Faculty) includes annual in-person meetings of students and trained faculty Career Coaches, along with ongoing virtual coaching, group meetings and communication. The model is being tested as a randomized controlled trial with two cohorts of biomedical PhD students from across the U.S., one recruited at the start of their PhDs and one nearing completion. Stratification into the experimental and control groups, and to coaching groups within the experimental arms, achieved equal numbers of students by race, ethnicity and gender to the extent possible. A fundamental design element of the Academy is to teach and make visible the social science principles which highly influence scientific advancement, as well as acknowledging the extra challenges faced by underrepresented groups working to be seen as legitimate within the scientific communities. Discussion. The strategy being tested is based upon a novel application of the well-established principles of deploying highly skilled coaches, selected and trained for their ability to develop talents of others. This coaching model is intended to be a complement, rather than a substitute, for traditional mentoring in biomedical research training, and is being tested as such. © 2014 Thakore et al.; licensee BioMed Central Ltd. Source

Filus J.K.,Oakton Community College | Filus L.Z.,Northeastern Illinois University
AIP Conference Proceedings | Year: 2012

The classic bivariate and multivariate Gaussian probability density' pattern is recognized as a special case of the more general "parameter dependence" paradigm for the stochastic dependence between random variables. This recognition leads to formulation of new method for the construction of many other (than the normal) multivariate densities called "pseudodistributions". The latter preserve some essential properties of the Gaussian case. © 2012 American Institute of Physics. Source

Papadopoulou M.V.,NorthShore University HealthSystem | Bloomer W.D.,NorthShore University HealthSystem | Lepesheva G.I.,Vanderbilt University | Rosenzweig H.S.,Oakton Community College | And 7 more authors.
Journal of Medicinal Chemistry | Year: 2015

3-Nitro-1H-1,2,4-triazole-based amides with a linear, rigid core and 3-nitrotriazole-based fluconazole analogues were synthesized as dual functioning antitrypanosomal agents. Such compounds are excellent substrates for type I nitroreductase (NTR) located in the mitochondrion of trypanosomatids and, at the same time, act as inhibitors of the sterol 14α-demethylase (T. cruzi CYP51) enzyme. Because combination treatments against parasites are often superior to monotherapy, we believe that this emerging class of bifunctional compounds may introduce a new generation of antitrypanosomal drugs. In the present work, the synthesis and in vitro and in vivo evaluation of such compounds is discussed. © 2015 American Chemical Society. Source

Papadopoulou M.V.,NorthShore University HealthSystem | Bloomer W.D.,NorthShore University HealthSystem | Rosenzweig H.S.,Oakton Community College | Arena A.,San Diego State University | And 3 more authors.
Antimicrobial Agents and Chemotherapy | Year: 2014

Twenty-three 3-nitrotriazole-based and 2-nitroimidazole-based amides and sulfonamides were screened for antitubercular (anti- TB) activity in aerobic Mycobacterium tuberculosis H37Rv by using the BacTiter-Glo (BTG) microbial cell viability assay. In general, 3-nitrotriazole-based sulfonamides demonstrated anti-TB activity, whereas 3-nitrotriazole-based amides and 2-nitroimidazole- based amides and sulfonamides were inactive. Three 3-nitrotriazole-based sulfonamides (compounds 4, 2, and 7) demonstrated 50% inhibitory concentration (IC50), IC90, and MIC values of 0.38, 0.43, and 1.56 M(compound 4), 0.57, 0.98, and 3.13 μM(compound 2), and 0.79, 0.87, and 3.13 μM(compound 7), respectively. For 3-nitrotriazole-based sulfonamides, anti-TB activity increased with lipophilicity, whereas the one-electron reduction potential (E1/2) did not play a role. 2-Nitroimidazole- based analogs, which were inactive in the BTG assay, were significantly more active in the low-oxygen assay and more active than the 3-nitrotriazoles. All active nitrotriazoles in the BTG assay were similarly active or more potent (lower MIC values) against resistant strains, with the exception of compounds 2, 3, 4, and 8, which demonstrated greater MIC values against isoniazid- resistant strains. Five 3-nitrotriazole-based sulfonamides demonstrated activity in infected murine J774 macrophages, causing log reductions similar to those seen with rifampin. However, some compounds caused toxicity in uninfected macrophages. In conclusion, the classes of 3-nitrotriazole-based amides and sulfonamides merit further investigation as potential antitubercular agents. © 2014, American Society for Microbiology. All Rights Reserved. Source

Papadopoulou M.V.,NorthShore University HealthSystem | Bloomer W.D.,NorthShore University HealthSystem | Rosenzweig H.S.,Oakton Community College | Kaiser M.,Swiss Tropical and Public Health Institute | And 3 more authors.
Bioorganic and Medicinal Chemistry | Year: 2013

We have previously shown that 3-nitro-1H-1,2,4-triazole-based amines demonstrate significant trypanocidal activity, in particular against Trypanosoma cruzi, the causative parasite of Chagas disease. In the present work we further expanded our research by evaluating in vitro the trypanocidal activity of nitrotriazole-based piperazines and nitrotriazole-based 2-amino-1,3- benzothiazoles to establish additional SARs. All nitrotriazole-based derivatives were active or moderately active against T. cruzi; however two of them did not fulfill the selectivity criteria. Five derivatives were active or moderately active against Trypanosoma brucei rhodesiense while one derivative was moderately active against Leishmania donovani. Active compounds against T. cruzi demonstrated selectivity indexes (toxicity to host cells/toxicity to T. cruzi amastigotes) from 117 to 1725 and 12 of 13 compounds were up to 39-fold more potent than the reference compound benznidazole. Detailed SARs are discussed. © 2013 Elsevier Ltd. All rights reserved. Source

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