Oakton Community College

Des Plaines, IL, United States

Oakton Community College

Des Plaines, IL, United States
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News Article | May 5, 2017
Site: www.prweb.com

LearnHowToBecome.org, a leading resource provider for higher education and career information, has released its list of the Best Colleges in Illinois for 2017. 50 four-year colleges were ranked, with Northwestern University, University of Chicago, Bradley University, Illinois Institute of Technology and Augustana College taking the top five spots on the list. 49 two-year schools were also selected; Carl Sandburg College, Illinois Central College, Richland Community College, Rend Lake College and Lincoln Land Community College were the top five. A complete list of schools is included below. “The schools on our list have shown that they offer outstanding educational programs that set students up for post-college success,” said Wes Ricketts, senior vice president of LearnHowToBecome.org. “Students exploring higher education options in Illinois can also look to these schools to provide top-quality resources that help maximize the overall educational experience.” To be included on the “Best Colleges in Illinois” list, all schools must be not-for-profit and regionally accredited. Each college is also evaluated metrics including annual alumni earnings, the opportunity for employment services and academic counseling, the selection of degree programs offered, financial aid availability and graduation rates. Complete details on each college, their individual scores and the data and methodology used to determine the LearnHowToBecome.org “Best Colleges in Illinois” list, visit: The Best Four-Year Colleges in Illinois for 2017 include: Augustana College Aurora University Benedictine University Blackburn College Bradley University Chicago State University Concordia University-Chicago DePaul University Dominican University Eastern Illinois University Elmhurst College Eureka College Governors State University Greenville College Illinois College Illinois Institute of Technology Illinois State University Illinois Wesleyan University Judson University Knox College Lake Forest College Lewis University Loyola University Chicago MacMurray College McKendree University Millikin University Monmouth College National Louis University North Central College North Park University Northern Illinois University Northwestern University Olivet Nazarene University Principia College Quincy University Rockford University Roosevelt University Rush University Saint Xavier University Southern Illinois University-Carbondale Southern Illinois University-Edwardsville Trinity Christian College Trinity International University-Illinois University of Chicago University of Illinois at Chicago University of Illinois at Springfield University of Illinois at Urbana-Champaign University of St Francis Western Illinois University Wheaton College The Best Two-Year Colleges in Illinois for 2017 include: Black Hawk College Carl Sandburg College City Colleges of Chicago - Harry S Truman College City Colleges of Chicago - Malcolm X College City Colleges of Chicago - Wilbur Wright College City Colleges of Chicago-Harold Washington College City Colleges of Chicago-Kennedy-King College City Colleges of Chicago-Olive-Harvey College City Colleges of Chicago-Richard J Daley College College of DuPage College of Lake County Danville Area Community College Elgin Community College Frontier Community College Harper College Heartland Community College Highland Community College Illinois Central College Illinois Valley Community College John A Logan College John Wood Community College Joliet Junior College Kankakee Community College Kaskaskia College Kishwaukee College Lake Land College Lewis and Clark Community College Lincoln Land Community College Lincoln Trail College MacCormac College McHenry County College Moraine Valley Community College Morton College Oakton Community College Olney Central College Parkland College Prairie State College Rend Lake College Richland Community College Rock Valley College Sauk Valley Community College Shawnee Community College South Suburban College Southeastern Illinois College Southwestern Illinois College Spoon River College Triton College Wabash Valley College Waubonsee Community College ### About Us: LearnHowtoBecome.org was founded in 2013 to provide data and expert driven information about employment opportunities and the education needed to land the perfect career. Our materials cover a wide range of professions, industries and degree programs, and are designed for people who want to choose, change or advance their careers. We also provide helpful resources and guides that address social issues, financial aid and other special interest in higher education. Information from LearnHowtoBecome.org has proudly been featured by more than 700 educational institutions.

Papadopoulou M.V.,NorthShore University HealthSystem | Bloomer W.D.,NorthShore University HealthSystem | Rosenzweig H.S.,Oakton Community College | Kaiser M.,Swiss Tropical and Public Health Institute | Kaiser M.,University of Basel
European Journal of Medicinal Chemistry | Year: 2017

A limited number of novel 3-nitrotriazole- and 2-nitroimidazole-linked quinolines and quinazolines were synthesized and screened for in vitro antitrypanosomal and antitubercular activities as well as cytotoxicity in normal cells. All compounds were active against T. cruzi amastigotes, while all but one were active or moderately active against T. b. rhodesiense. However, only two chloroquinolines exhibited satisfactory selectivity indices (SI) against T. cruzi and only one of them demonstrated a satisfactory SI against T. b. rhodesiense. All tested compounds demonstrated a Minimum Inhibitory Concentration (MIC) ≥ 200 μM against aerobic Mtb. However, the 2-nitroimidazole-based analogs were active against hypoxic Mtb with MIC values 2.89–9.18 μM. The present data support our previous observations that 2-nitroimidazole-based aromatic amines are selectively active against nonreplicating Mtb, while 3-nitrotriazole-based aromatic amines are potent antichagasic agents. © 2017 Elsevier Masson SAS

Papadopoulou M.V.,NorthShore University HealthSystem | Bloomer W.D.,NorthShore University HealthSystem | Lepesheva G.I.,Vanderbilt University | Rosenzweig H.S.,Oakton Community College | And 7 more authors.
Journal of Medicinal Chemistry | Year: 2015

3-Nitro-1H-1,2,4-triazole-based amides with a linear, rigid core and 3-nitrotriazole-based fluconazole analogues were synthesized as dual functioning antitrypanosomal agents. Such compounds are excellent substrates for type I nitroreductase (NTR) located in the mitochondrion of trypanosomatids and, at the same time, act as inhibitors of the sterol 14α-demethylase (T. cruzi CYP51) enzyme. Because combination treatments against parasites are often superior to monotherapy, we believe that this emerging class of bifunctional compounds may introduce a new generation of antitrypanosomal drugs. In the present work, the synthesis and in vitro and in vivo evaluation of such compounds is discussed. © 2015 American Chemical Society.

Papadopoulou M.V.,NorthShore University HealthSystem | Bloomer W.D.,NorthShore University HealthSystem | Rosenzweig H.S.,Oakton Community College | Arena A.,San Diego State University | And 3 more authors.
Antimicrobial Agents and Chemotherapy | Year: 2014

Twenty-three 3-nitrotriazole-based and 2-nitroimidazole-based amides and sulfonamides were screened for antitubercular (anti- TB) activity in aerobic Mycobacterium tuberculosis H37Rv by using the BacTiter-Glo (BTG) microbial cell viability assay. In general, 3-nitrotriazole-based sulfonamides demonstrated anti-TB activity, whereas 3-nitrotriazole-based amides and 2-nitroimidazole- based amides and sulfonamides were inactive. Three 3-nitrotriazole-based sulfonamides (compounds 4, 2, and 7) demonstrated 50% inhibitory concentration (IC50), IC90, and MIC values of 0.38, 0.43, and 1.56 M(compound 4), 0.57, 0.98, and 3.13 μM(compound 2), and 0.79, 0.87, and 3.13 μM(compound 7), respectively. For 3-nitrotriazole-based sulfonamides, anti-TB activity increased with lipophilicity, whereas the one-electron reduction potential (E1/2) did not play a role. 2-Nitroimidazole- based analogs, which were inactive in the BTG assay, were significantly more active in the low-oxygen assay and more active than the 3-nitrotriazoles. All active nitrotriazoles in the BTG assay were similarly active or more potent (lower MIC values) against resistant strains, with the exception of compounds 2, 3, 4, and 8, which demonstrated greater MIC values against isoniazid- resistant strains. Five 3-nitrotriazole-based sulfonamides demonstrated activity in infected murine J774 macrophages, causing log reductions similar to those seen with rifampin. However, some compounds caused toxicity in uninfected macrophages. In conclusion, the classes of 3-nitrotriazole-based amides and sulfonamides merit further investigation as potential antitubercular agents. © 2014, American Society for Microbiology. All Rights Reserved.

Papadopoulou M.V.,NorthShore University HealthSystem | Bloomer W.D.,NorthShore University HealthSystem | Rosenzweig H.S.,Oakton Community College | Kaiser M.,Swiss Tropical and Public Health Institute | And 3 more authors.
Bioorganic and Medicinal Chemistry | Year: 2013

We have previously shown that 3-nitro-1H-1,2,4-triazole-based amines demonstrate significant trypanocidal activity, in particular against Trypanosoma cruzi, the causative parasite of Chagas disease. In the present work we further expanded our research by evaluating in vitro the trypanocidal activity of nitrotriazole-based piperazines and nitrotriazole-based 2-amino-1,3- benzothiazoles to establish additional SARs. All nitrotriazole-based derivatives were active or moderately active against T. cruzi; however two of them did not fulfill the selectivity criteria. Five derivatives were active or moderately active against Trypanosoma brucei rhodesiense while one derivative was moderately active against Leishmania donovani. Active compounds against T. cruzi demonstrated selectivity indexes (toxicity to host cells/toxicity to T. cruzi amastigotes) from 117 to 1725 and 12 of 13 compounds were up to 39-fold more potent than the reference compound benznidazole. Detailed SARs are discussed. © 2013 Elsevier Ltd. All rights reserved.

Papadopoulou M.V.,NorthShore University HealthSystem | Bloomer W.D.,NorthShore University HealthSystem | Rosenzweig H.S.,Oakton Community College | Ashworth R.,Queen Mary, University of London | And 5 more authors.
Future Medicinal Chemistry | Year: 2013

Background: Chagas disease is caused by the parasite Trypanosoma cruzi, is endemic in Latin America and leads to an estimated 14,000 deaths per year and around 100 million people at risk of infection. Drugs currently used in the treatment of Chagas are old, partially effective and have numerous side effects. Methodology: We have previously reported that 3-nitro-1H-1,2,4-triazole-based compounds demonstrate significant and selective activity against T. cruzi amastigotes in infected L6 cells via activation of a type I nitroreductase, specific to trypanosomatids. In the present work we evaluated in vivo 13 of these compounds based on their high in vitro potency against T. cruzi (IC 50 < 1 μM) and selectivity (SI: toxicity to L6 cells/toxicity against T. cruzi amastigotes > 200). Representative compounds of different chemical classes were included. A fast luminescence assay with transgenic parasites that express luciferase, and live imaging techniques were used. A total of 11 out of 13 compounds demonstrated significant antichagasic activity when administered intraperitoneally for 5-10 days at relatively small doses. The best in vivo activity was demonstrated by amides and sulfonamide derivatives. ADMET studies were performed for specific compounds. Conclusion: At least three compounds were identified as effective, non-toxic antichagasic agents suitable for further development. © 2013 Future Science Ltd.

Filus J.K.,Oakton Community College | Filus L.Z.,Northeastern Illinois University
AIP Conference Proceedings | Year: 2010

We define and investigate stochastic dependences that occurs in some vital problems in biomedical science as well as (in parallel) in reliability. Between others, we extend the classical model for stochastic dependence discovered by Cox in 1972 and widely applied in bio-medical investigations. Our extension is rather new and relies on adding to Cox's formula an additional term depending on some, possibly different than those in the original Cox formula, explanatory variables. These variables, in general, are random. Thus, the classical Cox formula becomes a special case of the model we consider. The so extended Cox pattern forms an essential general background for construction of some more specific stochastic models applied in reliability, and, first of all, in modeling a cancer-ill human's residual life time. Additionally, the extended model's analytical structure provides tools that facilitate analytical description of an additional pattern of 'parallelism' between some 'physical' phenomena and their stochastic reflections. © 2010 American Institute of Physics.

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