Contributions of specific and nonspecific interactions in the complexation of esters of 7-bromo-3-hydroxy-5-(o-chloro)phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-ones with central benzodiazepine receptors
Andronati S.A.,O V Bogatskii Physico Chemical Institute |
Smulsky S.P.,O V Bogatskii Physico Chemical Institute |
Pavlovsky V.I.,O V Bogatskii Physico Chemical Institute |
Boyko I.A.,O V Bogatskii Physico Chemical Institute |
And 2 more authors.
Theoretical and Experimental Chemistry | Year: 2012
Radioligand analysis at 0-35 °C was used to find that 3-(alkylcarbonyloxy)-7-bromo-5-(o-chloro)phenyl-1,2-dihydro-3H-1,4-benzodiazepin-2-ones react differently with central benzodiazepine receptors. The complexation of the 3-acetyloxy derivative proceeds endothermally with ΔS0 as the driving force. The reaction of the other esters is accompanied by favorable change of both entropy and enthalpy. © 2012 Springer Science+Business Media New York.