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Autio H.,University of Helsinki | Matlik K.,University of Helsinki | Rantamaki T.,University of Helsinki | Lindemann L.,Hoffmann-La Roche | And 4 more authors.
Neuropharmacology | Year: 2011

Acetylcholinesterase inhibitors are first-line therapies for Alzheimer's disease. These drugs increase cholinergic tone in the target areas of the cholinergic neurons of the basal forebrain. Basal forebrain cholinergic neurons are dependent upon trophic support by nerve growth factor (NGF) through its neurotrophin receptor, TrkA. In the present study, we investigated whether the acetylcholinesterase inhibitors donepezil and galantamine could influence neurotrophin receptor signaling in the brain. Acute administration of donepezil (3 mg/kg, i.p.) led to the rapid autophosphorylation of TrkA and TrkB neurotrophin receptors in the adult mouse hippocampus. Similarly, galantamine dose-dependently (3, 9 mg/kg, i.p.) increased TrkA and TrkB phosphorylation in the mouse hippocampus. Both treatments also increased the phosphorylation of transcription factor CREB and tended to increase the phosphorylation of AKT kinase but did not alter the activity of MAPK42/44. Chronic treatment with galantamine (3 mg/kg, i.p., 14 days), did not induce changes in hippocampal NGF and BDNF synthesis or protein levels. Our findings show that acetylcholinesterase inhibitors are capable of rapidly activating hippocampal neurotrophin signaling and thus suggest that therapies targeting Trk signaling may already be in clinical use in the treatment of AD. © 2011 Elsevier Ltd. All rights reserved.


Butler-Wu S.M.,University of Washington | Burns E.M.,University of Washington | Pottinger P.S.,University of Washington | Magaret A.S.,University of Washington | And 4 more authors.
Journal of Clinical Microbiology | Year: 2011

Propionibacterium acnes is increasingly recognized as an important agent of prosthetic joint infection (PJI). However, the optimum culture conditions for recovery of this organism from PJI specimens have not been determined. By applying a prolonged 28-day culture incubation to all periprosthetic specimens received for bacterial culture from 198 revision arthroplasty procedures, we retrospectively determined that a 13-day culture incubation period is necessary for the recovery of P. acnes from patients with PJI. Incubation beyond this period was associated with increasing recovery of nondiagnostic isolates: 21.7% of P. acnes isolates believed to be clinically unimportant were recovered after 13 days of incubation. Importantly, a diagnosis of P. acnes PJI would have been missed in 29.4% of patients had extended culture incubation been applied only to anaerobic culture media. Although specimens from P. acnes PJIs were more commonly associated with the presence of ≥2 culture media positive for growth, acute inflammation (≥5 neutrophils/high-power field) was observed in only 40% of patients with PJIs that had more than one specimen submitted for bacterial culture. These results support the need for a minimum culture incubation period of 13 days to be applied to both aerobic and anaerobic culture media for all periprosthetic specimens. Optimal recovery of infecting organisms from PJI specimens will be an important component in generating a universal definition for PJI due to indolent agents of infection, such as P. acnes. Copyright © 2011, American Society for Microbiology. All Rights Reserved.


Adams B.J.,NYC First | Aschheim K.W.,NYC First
Journal of Forensic Sciences | Year: 2016

Comparison of antemortem and postmortem dental records is a leading method of victim identification, especially for incidents involving a large number of decedents. This process may be expedited with computer software that provides a ranked list of best possible matches. This study provides a comparison of the most commonly used conventional coding and sorting algorithms used in the United States (WinID3) with a simplified coding format that utilizes an optimized sorting algorithm. The simplified system consists of seven basic codes and utilizes an optimized algorithm based largely on the percentage of matches. To perform this research, a large reference database of approximately 50,000 antemortem and postmortem records was created. For most disaster scenarios, the proposed simplified codes, paired with the optimized algorithm, performed better than WinID3 which uses more complex codes. The detailed coding system does show better performance with extremely large numbers of records and/or significant body fragmentation. © 2016 American Academy of Forensic Sciences.


PubMed | NYC First
Type: Journal Article | Journal: Journal of forensic sciences | Year: 2016

Comparison of antemortem and postmortem dental records is a leading method of victim identification, especially for incidents involving a large number of decedents. This process may be expedited with computer software that provides a ranked list of best possible matches. This study provides a comparison of the most commonly used conventional coding and sorting algorithms used in the United States (WinID3) with a simplified coding format that utilizes an optimized sorting algorithm. The simplified system consists of seven basic codes and utilizes an optimized algorithm based largely on the percentage of matches. To perform this research, a large reference database of approximately 50,000 antemortem and postmortem records was created. For most disaster scenarios, the proposed simplified codes, paired with the optimized algorithm, performed better than WinID3 which uses more complex codes. The detailed coding system does show better performance with extremely large numbers of records and/or significant body fragmentation.


NYC First | Entity website

On March 11-13, 2016 New York City FIRSTwill host over 200 competing robotics teams from the New York tri-state area, Arizona, Brazil, China, Ecuador, Turkey, the Netherlands, and the United Kingdom, with the winning teams advancing to the global competition. Featuring: FIRST Robotics Competition FIRST LEGO League Championship FIRST LEGO League Junior Expo FIRST Tech Challenge Expo Science and Technology College & Career Expo This event is free and open to the public ...


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FIRST LEGO League Jr. introduces 6 to 9 year-old children to the exciting worlds of science and technology ...


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New York City FIRST 101 Avenue of the Americas 18th Floor New York, NY 10013


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Copyright 2016 NYC FIRST | A Ciplex Design


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What is FIRST? VIDEO To transform our culture by creating a world where science and technology are celebrated andwhere young people dream of becoming science and technology leaders. Dean Kamen, Founder As part of a FIRST team, kids get to apply math and science knowledge, solve problems, make decisions, communicate complex ideas, collaborate as part of a team, exercise leadership, manage resources, create and execute business plans all essential skills in any successful technological enterprise ...


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Location:New York Hall of Science Event Coordinator:Maker Faire Contact: Other Information: Details to come

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