EDEN PRAIRIE, MN, United States
EDEN PRAIRIE, MN, United States

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Grant
Agency: National Science Foundation | Branch: | Program: STTR | Phase: Phase I | Award Amount: 224.47K | Year: 2013

This Small Business Technology Transfer Program (STTR) Phase I project will create a new salmonella sensor combining two established tools in biodetection: hydrodynamic chromatography and magnetic nanoparticle (MP) conjugation. The proposed sensor will be significantly less expensive and provide faster detection time with equivalent sensitivity compared to current techniques. The project will develop this sensor by exploiting the connection between the MP magnetic orientation, fluid behavior and volume characteristics. Functionally coated MPs will be combined with a salmonella aptamer biomarker in a microfluidic channel. A magnetic profile of the solution will be measured using ultrasensitive giant magnetoresistance sensors. The MP magnetic profile will change in the presence of the biomarker due to modification of the MPs? hydrodynamic volume. The goal of the Phase I program will be to demonstrate this difference in magnetic profiles. Successful completion of the program will result in a prototype sensor for food safety applications in the Phase II effort. The broader impact/commercial potential of this project could include food safety and medical applications. In the sizeable food processing industry the sensor is a highly efficient contamination monitor leading to dramatic improvements in food safety by preventing distribution of contaminated products. While the initial sensor will be designed for salmonella, the sensor is also extensible to other biomarkers and could be envisioned as a critical point-of-care sensor in the medical industry. The National Science Foundation?s mission will also be carried out by having graduate students and postdoctoral researchers participate in the program, exposing them to industry while developing new knowledge and honing their research skills.


Patent
Nve Corporation | Date: 2012-10-05

A mixed anisotropy magnetic field sensor includes a first magnetic material film having in-plane anisotropy with a first magnetic easy axis that is in-plane, a second magnetic material film having out-of-plane anisotropy with a second magnetic easy axis that is perpendicular to the first magnetic easy axis of the first magnetic material film, and a non-magnetic spacer between the first magnetic material film and the second magnetic material film. The first magnetic material film has a magnetization oriented in a first magnetization orientation parallel to the first magnetic easy axis in the presence of no applied magnetic field, and the second magnetic material film has a magnetization oriented in a second magnetization orientation parallel to the second magnetic easy axis in the presence of no applied magnetic field.


Patent
Nve Corporation | Date: 2014-07-07

An omnidirectional magnetoresistive magnetic field sensor includes a plurality of magnetic material film layers each having an equal thickness of less than 0.5 nanometers (nm), and a plurality of non-magnetic spacer layers between each of the magnetic material film layers.


Patent
Nve Corporation | Date: 2013-07-03

An MTJ sensor having low hysteresis and high sensitivity is disclosed. The MTJ sensor includes, in one embodiment, a bridge with first and second active MTJ elements and first and second passive MTJ elements connected in a Wheatstone bridge configuration. First and second magnetic shield elements are located over the first and second passive MTJ elements and form a gap therebetween that concentrates magnetic flux toward the first and second active MTJ elements. A three-dimensional coil is wound around the first and second magnetic shield elements with over-windings located over the first and second magnetic shield elements and under-windings located under the first and second magnetic shield elements, connected together by a plurality of vias adjacent the first and second magnetic shield elements. The MTJ sensor may be operated with circuitry configured to supply a reset current pulse through the three-dimensional coil sufficient to magnetically saturate the first and second active MTJ elements and the first and second passive MTJ elements, supply a monotonically increasing current with a polarity opposite to the reset current pulse through the three-dimensional coil, and determine a value of current through the three-dimensional coil when an output voltage of the bridge reaches an endpoint, such as zero volts.


Patent
Nve Corporation | Date: 2014-04-09

A mixed anisotropy magnetic field sensor includes a first magnetic material film having in-plane anisotropy with a first magnetic easy axis that is in-plane, a second magnetic material film having out-of-plane anisotropy with a second magnetic easy axis that is perpendicular to the first magnetic easy axis of the first magnetic material film, and a nonmagnetic spacer between the first magnetic material film and the second magnetic material film. The first magnetic material film has a magnetization oriented in a first magnetization orientation parallel to the first magnetic easy axis in the presence of no applied magnetic field, and the second magnetic material film has a magnetization oriented in a second magnetization orientation parallel to the second magnetic easy axis in the presence of no applied magnetic field. The magnetization of the first magnetic material film rotates to align with the magnetization of the second magnetic material film in the second magnetization orientation in the presence of an applied out-of-plane magnetic field exceeding a threshold, and the magnetization of the second magnetic material film rotates to align with the magnetization of the first magnetic material film in the first magnetization orientation in the presence of an applied in-plane magnetic field exceeding a threshold.


Grant
Agency: Department of Agriculture | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 99.98K | Year: 2015

1. This project will focus on detecting live Salmonella organisms in industry-relevant large sample volumes faster, at lower cost, and with comparable accuracy to existing methods. Salmonella is the most common cause of foodborne illness. The United States Center for Disease Control (CDC) estimates that Salmonella causes 19,000 hospitalizations and 380 deaths per year. Many of these cases could be prevented with improved detection. The primary roadblock to improved detection is the lack of in-situ, high-throughput detection technologies.2. The proposed novel sensor will combined existing technologies magnetic detection, surface modified magnetic particles and microfluidics.3. Successful demonstration and commercialization of the proposed sensor would dramatically improve food safety, reducing foodborne illness and death by providing faster and easier in-situ detection.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: | Award Amount: 227.97K | Year: 2013

This Small Business Technology Transfer Program (STTR) Phase I project will create a new salmonella sensor combining two established tools in biodetection: hydrodynamic chromatography and magnetic nanoparticle (MP) conjugation. The proposed sensor will be significantly less expensive and provide faster detection time with equivalent sensitivity compared to current techniques. The project will develop this sensor by exploiting the connection between the MP magnetic orientation, fluid behavior and volume characteristics. Functionally coated MPs will be combined with a salmonella aptamer biomarker in a microfluidic channel. A magnetic profile of the solution will be measured using ultrasensitive giant magnetoresistance sensors. The MP magnetic profile will change in the presence of the biomarker due to modification of the MPs? hydrodynamic volume. The goal of the Phase I program will be to demonstrate this difference in magnetic profiles. Successful completion of the program will result in a prototype sensor for food safety applications in the Phase II effort.


The broader impact/commercial potential of this project could include food safety and medical applications. In the sizeable food processing industry the sensor is a highly efficient contamination monitor leading to dramatic improvements in food safety by preventing distribution of contaminated products. While the initial sensor will be designed for salmonella, the sensor is also extensible to other biomarkers and could be envisioned as a critical point-of-care sensor in the medical industry. The National Science Foundation?s mission will also be carried out by having graduate students and postdoctoral researchers participate in the program, exposing them to industry while developing new knowledge and honing their research skills.


Grant
Agency: Department of Defense | Branch: Missile Defense Agency | Program: SBIR | Phase: Phase I | Award Amount: 124.93K | Year: 2015

This Small Business Innovation Research Phase I proposal will demonstrate the feasibility of an ultra-low power radio frequency (RF) field sensor based on novel magnetic tunnel junction (MTJ) technology. The sensor will be comprised of an MTJ sensing element that, when placed in a component or system, will monitor for perturbations in the ambient RF field profile during various stages of operation. The configured sensor is environmentally robust and is sensitive to the field direction. This project will also develop a low power complementary metal oxide semiconductor (CMOS) concept to provide digital readout of the measured signal with post processing to look for perturbations to be done off-chip. The results of this effort will provide a concise path forward for the fabrication of prototype sensors in the Phase II program. Approved for Public Release 14-MDA-8047 (14 Nov 14)


Grant
Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase I | Award Amount: 149.04K | Year: 2016

DESCRIPTION provided by applicant The goal of this Small Business Innovative Research project proposed to the National Institutes of Health in particular the National Institute on Deafness and Other Communication Disorders is the creation of a superior signal receiving component in hearing aids The proposed advanced magnetic field pickup will increase the potential to wirelessly link the hearing aids with handheld electronic devices allowing highly personalized and environmentally specific sound filtering and amplification to take place within the software or andquot appsandquot on the handheld device The proposed pickup uses magnetic tunnel junction MTJ technology to create a solid state magnetic field sensor a receiver for magnetic signals broadcast from the handheld device The proposed pickup is superior to the legacy telecoil in size power consumption and sensitivity over the full acoustic frequency spectrum The component offers significant improvement to the acoustic signal quality and enables a shift to simplify the in ear signal processing needs thus lowering hearing aid costs and increasing battery lifetime The specific goals for the pre prototype device are broadband response a minimum detectable signal of Oe Hz and a power draw of less than Watts in continuous operation The device size is expected to be at or less than mm on a side PUBLIC HEALTH RELEVANCE Advanced Magnetic Pickup for Hearing Aids Project Narrative The project goal will assist the hearing impaired by providing a higher quality of sound coming from standard hearing aids Hearing aids equipped with the proposed component will be better able to pick up magnetic signals from telephones electronic devices and auditorium loop broadcasting The component provides new links to computers and telecommunication devices


Grant
Agency: Department of Agriculture | Branch: | Program: SBIR | Phase: Phase II | Award Amount: 599.95K | Year: 2016

This Phase II Small Business Innovation Research proposal responds to food safety market needs by developing a high-throughput pathogen detector that will reduce the potential for disease outbreaks and costly food recalls. The device developed in this program addresses a broad sector of food producing markets. This project will focus on detecting live Salmonella organisms in industry-relevant large sample volumes faster, and with significantly higher sensitivity than state-of-the-art methods. The detection method uses DNA and RNA aptamers as biochemical "hooks" between Salmonella and magnetic nanoparticles. The magnetic nanoparticles are then detected by a novel tunneling magnetoresistance (TMR) lab-on-a-chip sensor. The key innovation is a unique microfluidics architecture that localizes Salmonella and bound magnetic nanoparticles to the location on the TMR sensor with the highest sensitivity while dramatically increasing throughput. NVE Corporation has assembled a team of experts from academia and industry for microfluidics design and fabrication, aptamer and magnetic nanoparticle creation, and magnetic TMR sensor production, yielding a highly specific and integrated detection solution. A feasibility prototype was successfully tested in the Phase I program. The goal of the Phase II is the construction of a high-throughput bench-top system with faster, higher-sensitivity detection of Salmonella than otherwise possible.This file MUST be converted to PDF prior to attachment in the electronic application package

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